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Protein production and protein delivery 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/06
  • C12N-005/08
  • C12N-015/85
출원번호 US-0243391 (1994-05-13)
발명자 / 주소
  • Treco Douglas A. (Arlington MA) Heartlein Michael W. (Boxborough MA) Selden Richard F. (Wellesley MA)
출원인 / 주소
  • Transkaryotic Therapies, Inc. (Cambridge MA 02)
인용정보 피인용 횟수 : 126  인용 특허 : 0

초록 ▼

The invention relates to constructs comprising: a) a targeting sequence; b) a regulatory sequence; c) an exon; and d) an unpaired splice-donor site. The invention further relates to a method of producing protein in vitro or in vivo comprising the homologous recombination of a construct as described

대표청구항 ▼

A homologously recombinant cell having incorporated therein a new transcription unit, wherein the new transcription unit comprises an exogenous regulatory sequence, an exogenous exon and a splice-donor site, operatively linked to the second exon of an endogenous gene, wherein the homologously recomb

이 특허를 인용한 특허 (126)

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