IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0525977
(1995-09-07)
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발명자
/ 주소 |
- Perricone Nicholas V. (27 Coginchaug Ct. Guilford CT 06437)
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| 인용정보 |
피인용 횟수 :
49 인용 특허 :
0 |
초록
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Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain catecholamines and/or related compounds in a dermatologically acceptable carrier. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine pr
Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain catecholamines and/or related compounds in a dermatologically acceptable carrier. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Preferred embodiments further contain at least one other ingredient that enhances neurotransmitter synthesis and/or skin penetration. In some embodiments, an acetylcholine precursor such as dimethylaminoethanol and/or a fatty acid ester of ascorbic acid are included in the formulation. In these and other embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, other cofactors such as vitamin B6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added.
대표청구항
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A method for the topical treatment of subcutaneous muscle and overlying cutaneous tissue comprising topically applying to affected skin areas a composition comprising, as active ingredients: (a) from about 0.25% to about 5% by weight of a catecholamine precursor selected from the group consisting of
A method for the topical treatment of subcutaneous muscle and overlying cutaneous tissue comprising topically applying to affected skin areas a composition comprising, as active ingredients: (a) from about 0.25% to about 5% by weight of a catecholamine precursor selected from the group consisting of tyrosine, phenylalanine, and mixtures thereof, (b) an effective amount of ascorbyl palmitate, and (c) about 0.25% to about 5% by weight of dimethylaminoethanol, in a dermatologically acceptable carrier that penetrates the skin so that muscle tone in subcutaneous muscle tissue is increased. A method for the topical treatment of aging subcutaneous muscle and overlying cutaneous tissue comprising topically applying to affected skin areas, in a dermatologically acceptable carrier that penetrates the skin, a composition comprising a catecholamine selected from the group consisting of dopamine, norepinephrine, epinephrine, dopa, serotonin, and mixtures thereof, or a catecholamine precursor selected from the group consisting of tyrosine, phenylalanine, and mixtures thereof, in amounts sufficient to increase muscle tone in the subcutaneous muscle tissue, wherein the composition further comprises a fat-soluble, saturated fatty acid ester of ascorbic acid selected from the group consisting of ascorbyl palmirate, ascorbyl laurate, ascorbyl myristate, ascorbyl stearate, and mixtures thereof, and about 0.25 to about 5% dimethylaminoethanol. A method for the topical treatment of aging subcutaneous muscle and overlying cutaneous tissue comprising topically applying to affected skin areas a composition comprising an effective amount of a catecholamine selected from the group consisting of dopamine, norepinepherine, epinepherine, dopa, seratonin, and mixtures thereof, or a catecholamine-related compound selected from the group consisting of phenylalanine, tyramine, ephedrine, amphetamine, tetrahydrobiopterin, pyridoxine, and mixtures thereof, in a dermatologically acceptable carrier that penetrates the skin.
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