[특허]Preparation of elongated seamless capsules containing a coaxial rod and biological material

Preparation of elongated seamless capsules containing a coaxial rod and biological material 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-011/04 C12N-005/00 B01J-013/02 A61K-009/48
출원번호	US-0430786 (1995-04-27)
발명자 / 주소	Aebischer Patrick (Barrington RI) Mills John F. (Wakefield RI) Wahlberg Lars (Providence RI) Doherty Edward J. (Mansfield MA) Tresco Patrick A. (Salt Lake City UT)
출원인 / 주소	Brown University Research Foundation (Providence RI 02)
인용정보	피인용 횟수 : 27 인용 특허 : 0

초록 ▼

Elongated seamless capsules containing biological material are prepared by a method in which a coagulant, which includes a cell suspension or other biological material, and a polymeric casting solution are extruded through a common extrusion port having at least two concentric bores, such that the coagulant is extruded through an inner bore and the polymeric casting solution is extruded through an outer bore. Extrusion of the coagulant is initiated subsequent to initiating delivery of the casting solution to form a capsule having a curved and smooth leading edge shape. Delivery of the coagulant is then shut off, and extrusion of the casting solution is terminated either immediately or after some predetermined time. This procedure can be modified to form in the capsule a coaxial rod that is connected to one end but not the other end of the capsule. This is accomplished by drawing casting solution into the inner bore after initiating extrusion of the casting solution through the outer bore, and then initiating delivery of the coagulant through the inner bore so as to coagulate the casting solution therein and form a rod, and ejecting the rod from the inner bore by pressure of the coagulant. Delivery of the coagulant and casting solution are then terminated as described above.

대표청구항 ▼

A method of integrally forming an elongated seamless capsule having a first end, a second end and a cell chamber with a coaxial and therein, the rod being connected to the first end of the capsule, but not the second end of the capsule, the method comprising the sequential steps of: initiating extrusion of a casting solution through a first outer bore of a multiple annular extrusion port; drawing casting solution into a second inner bore of the extrusion port, the second inner bore comprising a delivery channel and a plunger slidably extending therethrough, the second inner bore being configured such that the upstroke of the plunger creates a vacuum sufficient to draw casting solution into the delivery channel, the amount of casting solution being sufficient to form a coaxial rod when coagulated; subsequently initiating delivery of a coagulant through the delivery channel of the second inner bore of the extrusion port to form a coextruded inner core and achieve a first end of a seamless capsule, the coagulant comprising an aqueous solution containing biological material, wherein delivery of the coagulant is at a pressure sufficient to eject the coaxial rod from the inner bore; terminating delivery of the coagulant; and subsequently terminating delivery of the casting solution such that essentially no extruded casting solution remains attached to the nozzle to achieve a smooth second end of the seamless capsule so that the coaxial rod extends through the capsule and is continuous with the first end but not the second end, the coagulant with the biological material being contained within the seamless capsule; wherein the casting solution and the coagulant are selected so that coagulation of the casting solution occurs as the casting solution and the coagulant are extruded through the extrusion port.

이 특허를 인용한 특허 (27)

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Emmanuel C. Opara, Methods of culturing and encapsulating pancreatic islet cells.
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Bleiweiss Herman,ARX ; Bleiweiss Eduardo Samuel,ARX ; Bleiweiss Daniel Gustavo,ARX, Pharmaceutical formulations and methods for treating patients suffering from diseases that cause muscular hypotonia.
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DiPerna, Paul M., Slideable flow metering devices and related methods.
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Rees Riley S. ; Marcelo Cynthia ; Adamson Belinda ; Rhodes Lenore ; Marchant Beverly ; Lindblad William ; Gilmont Robert ; Garner Warren ; Zuccaro Cynthia ; Taddonio Thomas E., Wound treatment with keratinocytes on a solid support enclosed in a porous material.
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Preparation of elongated seamless capsules containing a coaxial rod and biological material 원문보기

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