[특허]Liquid polymer composition and method of use

Liquid polymer composition and method of use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-006/00
출원번호	US-0428825 (1995-04-25)
발명자 / 주소	Friedman Michael (Jerusalem ILX) Sintov Amnon (Jerusalem ILX)
출원인 / 주소	Perio Products, Ltd. (Jerusalem ILX 03) Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem ILX 03)
인용정보	피인용 횟수 : 31 인용 특허 : 0

초록 ▼

The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.

대표청구항 ▼

A method of treating fungal diseases in the oral cavity, said method comprising topical application of an efficacious amount of a liquid polymer composition to the teeth, gingival tissues or oral mucosal tissue of an animal or human, said liquid polymer composition consisting essentially of: (a) one or more sustained release acrylic polymers; (b) a pharmacological agent; (c) a release adjusting agent; and (d) a pharmaceutically acceptable vehicle; wherein said sustained release acrylic polymers are selected from the group consisting of: (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1; (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2; (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20; and (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40; and wherein said release adjusting agent is selected from the group consisting of: a cross-linking agent, a polysaccharide, a lipid, a non-polysaccharide polyhydroxy compound, a polycarboxylic acid salt, a divalent cation of calcium or strontium, a protein, citric acid, a sodium citrate, sodium docusate, polyoxyethylenesorbitan monooleate, and an amino acid.

이 특허를 인용한 특허 (31)

Keller, Duane C, Article and method for controlling oral-originated systemic disease.
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Keller, Duane C., Article and method for controlling oral-originated systemic disease.
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Glassman, Bradley P.; Bhagwat, Dileep; Glassman, Daniel, Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use.
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Adachi, Hirotoshi; Kuzumaki, Noriyuki; Arimoto, Tetsuya; Higo, Naruhito, Composition and device structure for iontophoresis.
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Ni,Yawei; Yates,Kenneth M., Delivery of physiological agents with in-situ gels comprising anionic polysaccharides.
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Faasse, Adrian L.; Klemm, Steven Richard; Groeneweg, Glen Edward; Thelen, Alan Gene, Device and method for delivering an oral care agent.
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Willison, Michael P.; Townshend, Joseph C.; Bryan, Christopher D.; Beskar, Emilie S.; Mudumba, Sreenivasu; Faasse, Adrian; Lai, Janet, Device and method for delivering an oral care agent.
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Keller, Duane C., Devices and methods for creating a positive pressure environment for treatment of oral biofilms associated with periodontal disease.
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Bruce, Craig, Facial lift.
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Battaglia, Alex, Film-forming resins as a carrier for topical application of pharmacologically active agents.
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Stookey, George K.; Herron, Christopher J.; Krone, Richard A.; Swanson, Jerome E., Fluoride varnish.
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Battaglia, Alex; Beim, Eva, Gum resin as a carrier for topical application of pharmacologically active agents.
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Ni, Yawei; Yates, Kenneth M.; Zarzycki, Ryszard, High molecular weight, low methoxyl pectins, and their production and uses.
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Ni, Yawei; Yates, Kenneth M., In-situ gel formation of pectin.
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Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Göpferich, Achim, Method of controlled drug delivery from implant device.
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Keller, Duane C., Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations.
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Williams, Jeffrey D.; Archibald, Bob D., Multi-surface anti-bacterial protective device.
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Lizio, Rosario; Petereit, Hans-Ulrich; Roth, Erna; Damm, Michael; Alexowsky, Ruediger, Partly neutralised anionic (meth) acrylate copolymer.
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Keller, Duane C., Periodontal device for changing a pressure in an enclosed environment about a tooth for treatment of oral biofilms associated with periodontal disease.
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Ni, Yawei; Yates, Kenneth M.; Zarzycki, Ryszard, Pharmaceutical compositions comprising aloe pectins, and methods for their production and use.
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Lerner E. Itzhak,ILX ; Rosenberger Vered,ILX ; Flashner Moshe,ILX, Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity.
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Sun, Yuyu; Cao, Zhengbing; Sun, Xinbo, Rechargeable long-term antifungal denture materials.
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Lin, Chang-Yi; Lu, Yunn-Tzer; Liu, Dean-Mo, Stable and taste masked pharmaceutical dosage form using porous apatite grains.
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Tricca, Robert E.; Wu, Benjamin M.; Li, Chunhua; Kuo, Eric, Systems and methods for intra-oral diagnosis.
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Li, Chunhua; Carlyle, Wenda C.; De Smedt, Philippe; Abolfathi, Amir; Kuo, Eric E.; Tricca, Robert E.; Chen, Jennifer C.; Wu, Benjamin M., Systems and methods for intra-oral drug delivery.
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Li, Chunhua; Carlyle, Wenda C.; De Smedt, Philippe; Abolfathi, Amir; Kuo, Eric E.; Tricca, Robert E.; Chen, Jennifer C.; Wu, Benjamin M., Systems and methods for intra-oral drug delivery.
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Patacca,Thomas R.; Patacca,Gregory G.; Frate,Dean M., Tooth coating composition.
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Ayon-Covarrubias Blas,MXXITX 63740, Topical antifungal treatment.
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Linden Lars .ANG.ke,SEX, Treatment of tooth surfaces and substance therefor.
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Linden Lars Ake,SEX, Treatment of tooth surfaces and substances therefor.
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Jeng David K., Water resistant film-forming antimicrobial skin-preparation.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Liquid polymer composition and method of use 원문보기

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Liquid polymer composition and method of use 원문보기

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