초록 ▼

The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease res

The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

대표청구항 ▼

A hybrid oligonucleotide that is complementary to a target RNA, the hybrid oligonucleotide consisting of phosphorothioate nucleotides and comprising a segment of at least two contiguous 2′-O-methyl-substituted ribonucleotides as the terminal two nucleotides at each end of the oligonucleotide, and fu

A hybrid oligonucleotide that is complementary to a target RNA, the hybrid oligonucleotide consisting of phosphorothioate nucleotides and comprising a segment of at least two contiguous 2′-O-methyl-substituted ribonucleotides as the terminal two nucleotides at each end of the oligonucleotide, and further comprising a segment of at least three contiguous deoxyribonucleotides.