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Solubility parameter based drug delivery system and method for altering drug saturation concentration 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-013/02
출원번호 US-0178558 (1994-01-07)
발명자 / 주소
  • Miranda Jesus (Miami FL) Sablotsky Steven (Miami FL)
출원인 / 주소
  • Noven Pharmaceuticals, Inc. (Miami FL 02)
인용정보 피인용 횟수 : 366  인용 특허 : 0

초록 ▼

A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and throu

대표청구항 ▼

A transdermal drug delivery system comprising a pressure-sensitive adhesive composition, wherein said composition comprises a blend of (a) a pressure-sensitive adhesive selected from the group consisting of (i) polyisoprene, polystyrene, polyethylene, polybutadiene , polyethylene/butylene, styrene/b

이 특허를 인용한 특허 (366)

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  148. Perricone, Nicholas V., Methods and compositions for muscular and neuromuscular diseases.
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  149. Perricone, Nicholas V., Methods and systems for treating or preventing cancer.
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  150. Perricone, Nicholas V., Methods and systems for treating or preventing cancer.
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  151. Perricone, Nicholas V., Methods and systems for treating or preventing cancer.
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  152. Perricone, Nicholas V., Methods and systems for treating or preventing cancer.
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  153. Perricone, Nicholas V., Methods and systems for treatment of inflammatory diseases with nitric oxide.
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  154. Perricone, Nicholas V., Methods and systems for treatment of inflammatory diseases with nitric oxide.
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  155. Perricone, Nicholas V., Methods and systems for treatment of inflammatory diseases with nitric oxide.
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  156. Perricone, Nicholas V., Methods and systems for treatment of inflammatory diseases with nitric oxide.
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  157. Murdock, Robert W.; Williams, C. Donald, Methods and transdermal compositions for pain relief.
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  158. Robert W. Murdock ; C. Donald Williams, Methods and transdermal compositions for pain relief.
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  159. Franz,G. Andrew; Strauss,Elaine A.; DiMenna,Phillip A.; Gemma,Rocco L., Methods of administering levothyroxine pharmaceutical compositions.
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  160. Perricone, Nicholas V.; Potini, Chim, Methods of delivering stable topical drug compositions.
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  161. Perricone, Nicholas V.; Potini, Chim, Methods of delivering stable topical drug compositions.
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  162. Cuevas Sànchez, Pedro, Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer.
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  163. Cuevas Sanchez, Pedro, Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis.
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  164. Cuevas Sànchez, Pedro, Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis.
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  165. Cuevas Sánchez, Pedro, Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis.
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  166. Burton, Scott A.; Ng, Chin-Yee; Frits, Michael J.; Mathias, Richard R., Microneedle injection and infusion apparatus and method of using same.
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  167. Burton, Scott A.; Ng, Chin-Yee; Mathias, Richard R.; Ford, Thomas D. R., Microneedle injection apparatus comprising a dual cover.
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  168. Burton, Scott A.; Ng, Chin-Yee; Mathias, Richard R., Microneedle injection apparatus comprising an inverted actuator.
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  169. Matson,Charles J.; Chen,Yen Lane; Ruth,Daniel T.; Benes,Luce R. M.; Burgaud,Sophie G.; Horriere,Francoise L. R.; Seyler,Isabelle M. L., Mucosal originated drug delivery systems and animal applications.
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  170. Strauss, Robert C., Multi-layer transdermal drug delivery device.
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  171. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  172. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  173. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  174. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  175. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  176. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  177. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  178. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  179. Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  180. Bernick, Brian A.; Persicaner, Peter H. R.; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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  181. Cleary, Gary W.; Parandoosh, Shoreh; Feldstein, Mikhail M.; Chalykh, Anatoly E.; Platè, Nicolai A.; Kulichikhin, Valery G., Non-electrically conductive hydrogel composition.
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  182. Silverberg, Eric; Chandran, Rama; Foreman, Paul; Philbin, Michael; Shah, Smita, Non-reactive adhesive useful in transdermal drug delivery system.
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  183. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Once daily dosage forms of trospium.
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  184. Kidane, Argaw; Flanner, Henry H.; Bhatt, Padmanabh; Raoufinia, Arash, Once daily dosage forms of trospium.
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  185. Tojo,Kakuji; Isowaki,Akiharu, Ophthalmic adhesive preparations for percutaneous adsorption.
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  186. Maitra, Prithwiraj; Zaidel, Lynette; Chopra, Suman K.; Pan, Guisheng; Prencipe, Michael; Ibrahim, Sayed, Oral care compositions with film forming polymers.
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  187. Rajaiah, Jayanth; Ernst, Lisa Catron; Case, Ann Maria; Ha, Thinh Nguyen; Glandorf, William Michael; Mayer, Christopher Robert, Oral care kits and compositions.
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  188. Jan Steve ; Cheng Xiu Xiu ; Chen Chih-Ming, Oral dosage for the controlled release of analgesic.
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  189. Kanios, David P.; Mantelle, Juan A.; Johnson, Paul; Li, Chensheng, Packaging system for transdermal drug delivery systems.
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  190. Sirinyan Kirkor,DEX ; Dorn Hubert,DEX ; Kujanek Richard,DEX ; Krieger Klemens,MXX ; Heukamp Ulrich,DEX ; Hackemuller Doris,DEX ; Hopkins Terence,AUX, Parasiticide formulations suitable for dermal application.
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  191. Irianni, Giuseppe, Patch containing diclofenac and thiocolchicoside.
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  192. Fischer, Wilfried; Sendl-Lang, Anna; Zeh-Herwerth, Dagmar, Patch for transdermal application for pergolid.
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  193. Perricone, Nicholas V., Peptide systems and methods for metabolic conditions.
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  194. Perricone, Nicholas V., Peptide systems and methods for metabolic conditions.
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  195. Perricone, Nicholas V., Peptide systems and methods for metabolic conditions.
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  196. Perricone, Nicholas V., Peptide systems and methods for metabolic conditions.
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  197. Perricone, Nicholas V., Peptide systems and methods for metabolic conditions.
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  198. Hori Mitsuhiko,JPX ; Minomi Kenjiro,JPX ; Nakano Yoshihisa,JPX, Percutaneous absorption preparation.
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  199. Dudley, Robert E.; Drouin, Dominique, Pharmaceutical composition and method for treating hypogonadism.
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  200. Dudley, Robert E.; Drouin, Dominique, Pharmaceutical composition and method for treating hypogonadism.
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  201. Dudley, Robert E.; Kottayil, S. George; Palatchi, Olivier, Pharmaceutical composition and method for treating hypogonadism.
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  202. Whittle Robert R. ; Sancilio Frederick D. ; Stowell Grayson Walker ; Jenkins Douglas John ; Whittall Linda B. ; Meyer Glenn Alan, Pharmaceutical formulations.
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  203. Whittle Robert R. ; Sancilio Frederick D. ; Stowell Grayson Walker ; Jenkins Douglas John ; Whittall Linda B. ; Fontana Steven A., Pharmaceutical unit dosage form.
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  204. Whittle Robert R. ; Sancilio Frederick D. ; Stowell Grayson Walker ; Jenkins Douglas John ; Whittall Linda B. ; Meyer Glenn Alan ; Fontana Steven A., Pharmaceutical unit dosage form.
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  205. Jayanth Rajaiah ; Lisa Catron Ernst ; Ann Maria Case ; Thinh Nguyen Ha ; William Michael Glandorf ; Christopher Robert Mayer, Polybutene containing denture cleanser compositions.
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  206. Feldstein, Mikhail M.; Platè, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
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  207. Feldstein, Mikhail M.; Platè, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
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  208. Kaufman, Herbert E., Preparations and methods for ameliorating or reducing presbyopia.
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  209. Kaufman, Herbert E., Preparations and methods for ameliorating or reducing presbyopia.
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  210. David Paul Kanios ; Juan Mantelle ; Linda Sue Nartker ; Victor Albert Raul ; Katherine Lynn Ulman, Pressure sensitive adhesive compositions for transdermal drug delivery devices.
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  211. Perricone, Nicholas V., Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery.
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  212. Perricone, Nicholas V., Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery.
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  213. Perricone, Nicholas V., Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery.
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  214. Tuba, Zoltán; Mahó, Sándor; Kiss, János; Magyari, Endréné; Terdy, László, Process for the synthesis of high purity -(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime.
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  215. Tuba, Zoltán; Mahó, Sándor; Keserü, György; Kozma, József; Horváth, János; Balogh, Gábor, Process of making isomers of norelgestromin and methods using the same.
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  216. Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Cacace, Janice Louise; Thorsteinsson, Thorsteinn; Sancilio, Frederick D., Progesterone formulations.
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  217. Singh, Parminder; Mudumba, Sri; Bairamov, Danir R.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
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  218. Singh, Parminder; Mudumba, Sri; Bayramov, Danir F.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
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  219. Awamura, Tsutomu; Furusawa, Kazuyoshi; Sawai, Yoshihiro, Rapidly soluble film preparation.
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  220. Gerstenberg,Knud Aage, Screw pump for transporting emulsions susceptible to mechanical handling.
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  221. Loubert, Gary Lee; Menjoulet, Tiffany Anne; Mitchell, Timothy Paul; Thomas, Xavier Jean-Paul, Silicone acrylate hybrid composition and method of making same.
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  222. Loubert, Gary; Mitchell, Timothy P.; Thomas, Xavier, Silicone acrylate hybride composition and method of making same.
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  223. Liu, Yuxia; Paul, Charles Willard; Ouyang, Jiangbo; Foreman, Paul B.; Sridhar, Laxmisha M.; Shah, Smita, Silicone acrylic hybrid polymer-based adhesives.
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  224. Evans, Chana Wilson; Huber, Robert O.; Kanios, David P.; Loubert, Gary Lee; Menjoulet, Tiffany Anne; Mitchell, Timothy Paul; Nartker, Linda Sue; Thomas, Xavier Jean-Paul, Single phase silicone acrylate formulation.
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  225. Zdeblick, Mark, Smart parenteral administration system.
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  226. Banister, Mark; Geronov, Yordan; McGrath, Dominic, Smart polymer materials with excess reactive molecules.
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  227. Chiang Chia-Ming ; Tenzel Renee Ann, Solid matrix system for transdermal drug delivery.
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  228. Chiang Chia-Ming ; Tenzel Renee Ann, Solid matrix system for transdermal drug delivery.
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  229. Sylvia Rossi-Montero ; Juan Mantelle ; David Kanios ; David Houze, Solubility enhancement of drugs in transdermal drug delivery systems and methods of use.
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  230. Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Irani, Neda; Cacace, Janice Louise; Thorsteinsson, Thorsteinn; Sancilio, Frederick D., Soluble estradiol capsule for vaginal insertion.
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  231. Andolino Brandt, Patricia J.; Leir, Charles M.; Wirtanen, David J., Spray on bandage and drug delivery system.
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  232. Franz,G. Andrew; Strauss,Elaine A.; DiMenna,Philip A.; Gemma,Rocco L., Stabilized pharmaceutical and thyroid hormone compositions and method of preparation.
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  233. Rao, Srinivasa; Dixit, Suresh; Yacobi, Avraham; Bailey, Arthur, Stable liquid desoximethasone compositions with reduced oxidized impurity.
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  234. Rao, Srinivasa; Dixit, Suresh; Yacobi, Avraham; Bailey, Arthur, Stable liquid desoximethasone compositions with reduced oxidized impurity.
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  235. Shadiack, Annette; Persicaner, Peter H. R.; Inskeep, Philip B.; Thorsteinsson, Thorsteinn; Sancilio, Frederick D.; Legassie, Jason D., Steroid hormone pharmaceutical composition.
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  236. Banister, Mark; McGrath, Dominic, Super elastic epoxy hydrogel.
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  237. Perricone, Nicholas V., Systems and methods for delivery of peptides.
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  238. Perricone, Nicholas V., Systems and methods for delivery of peptides.
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  239. Perricone, Nicholas V., Systems and methods for delivery of peptides.
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  240. Perricone, Nicholas V., Systems and methods for delivery of peptides.
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  241. Perricone, Nicholas V., Systems and methods for delivery of peptides.
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  242. Perricone, Nicholas V., Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system.
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  243. Perricone, Nicholas V., Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system.
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  244. Perricone, Nicholas V., Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system.
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  245. Perricone, Nicholas V., Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system.
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  246. Rajaiah, Jayanth; Ernst, Lisa Catron; Case, Ann Maria; Ha, Thinh Nguyen; Glandorf, William Michael; Mayer, Christopher Robert, Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier.
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  247. Perricone, Nicholas V., Techniques and systems for treatment of neuropathic pain and other indications.
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  248. Perricone, Nicholas V., Techniques and systems for treatment of neuropathic pain and other indications.
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  249. Perricone, Nicholas V., Techniques and systems for treatment of neuropathic pain and other indications.
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  250. Perricone, Nicholas V., Techniques and systems for treatment of neuropathic pain and other indications.
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  251. Malladi, Ramana; Miller, Jodi, Testosterone gel and method of use.
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  252. Malladi, Ramana; Miller, Jodi, Testosterone gel and method of use.
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  253. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  254. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  255. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  256. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  257. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  258. Malladi, Ramana; Stahlman, Jodi, Testosterone gel and method of use.
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  259. Duncan, Iain W.; Kesicki, Edward A.; Osborne, Carl G.; Schwieterman, William D.; Jacobson, Irina, Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits.
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  260. Duncan, Iain W.; Kesicki, Edward A.; Osborne, Carl G.; Schwieterman, William D.; Jacobson, Irina, Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits.
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  261. Duncan, Iain W.; Kesicki, Edward A.; Osborne, Carl G.; Schwieterman, William D.; Jacobson, Irina, Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits.
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  262. Duncan, Iain W.; Kesicki, Edward A.; Osborne, Carl G.; Schwieterman, William D.; Jacobson, Irina, Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits.
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  263. Prencipe, Michael; Chopra, Suman K.; Collins, Michael, Tooth whitening dental tray and method of use.
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  264. Prencipe, Michael; Chopra, Suman K.; Collins, Michael, Tooth whitening dental tray and method of use.
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  265. Sasaki, Yasuhiko; Matsumura, Yukihiro; Yamazaki, Masaru; Arai, Hiroshi; Kawabata, Shogo; Saito, Masaaki; Okuyama, Hirohisa; Suzuki, Makoto, Topical diclofenac patch.
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  266. Perricone, Nicholas V.; Sayed, Yousry Abdelrehim, Topical nitric oxide systems and methods of use thereof.
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  267. Perricone, Nicholas V.; Sayed, Yousry Abdelrehim, Topical nitric oxide systems and methods of use thereof.
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  268. Perricone, Nicholas V.; Sayed, Yousry Abdelrehim, Topical nitric oxide systems and methods of use thereof.
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  269. Perricone, Nicholas V., Topical systems and methods for treating sexual dysfunction.
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  270. Perricone, Nicholas V., Topical systems and methods for treating sexual dysfunction.
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  271. Perricone, Nicholas V., Topical systems and methods for treating sexual dysfunction.
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  272. Perricone, Nicholas V., Topical systems and methods for treating sexual dysfunction.
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  273. Mori Masao,JPX ; Saito Noriyasu,JPX, Tranilast-containing preparation for external application and method of producing the same.
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  274. Amano, Satoshi; Honma, Sachiko; Tateishi, Tetsuro; Kase, Natsumi, Transdermal absorption preparation.
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  275. Cantor, Adam S.; Stockholm, Andrew J., Transdermal adhesive patch assembly with removable microneedle array and method of using same.
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  276. Li, Chensheng; Nguyen, Viet, Transdermal administration of ACE inhibitors.
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  277. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  278. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  279. Singh, Parminder; Lee, Eun Soo; Jain, Amit K., Transdermal administration of tamsulosin.
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  280. Gale, Robert M.; Stein, Thomas M.; Audett, Jay; Stepic, Jane; Phipps, Joseph B.; Cormier, Michael J. N., Transdermal analgesic systems with reduced abuse potential.
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  281. Gale, Robert M.; Stein, Thomas M.; Audett, Jay; Stepic, Jane; Phipps, Joseph B.; Cormier, Michel J. N., Transdermal analgesic systems with reduced abuse potential.
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  282. Smith, Nicole; Palmer, Noel Erwin, Transdermal cannabinoid formulations.
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  283. Smith, Nicole; Palmer, Noel Erwin, Transdermal cannabinoid formulations.
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  284. Mantelle, Juan; Houze, David, Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures.
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  285. Mantelle, Juan; Houze, David, Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures.
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  286. Quan, Danyi; Venkateshwaran, Srinivasan; Ebert, Charles D., Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties.
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  287. Nguyen, Viet, Transdermal delivery of drugs based on crystal size.
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  288. Nguyen, Viet, Transdermal delivery of drugs based on crystal size.
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  289. Xiong, Weihong; Patel, Dinesh C., Transdermal delivery system for alkaloids of aconitum species.
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  290. Yum, Su Il; Theeuwes, Felix, Transdermal delivery system for sufentanil.
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  291. Yum, Su Il; Theeuwes, Felix, Transdermal delivery system for sufentanil.
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  292. Stefano, Francisco Jose Evaristo; Scasso, Alejandro Fabio, Transdermal delivery system with two superimposed adhesive layers having different affinities to the active substance comprised.
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  293. Yum, Su Il; Theeuwes, Felix, Transdermal delivery systems.
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  294. Sivaraman, Arunprasad; Simmons, Tyler D.; Fieldson, Gregory T.; Sorensen, Adam C.; Cortopassi, Jeffrey E., Transdermal dosage form for low-melting point active agent.
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  295. Sivaraman, Arunprasad; Simmons, Tyler D.; Fieldson, Gregory T.; Sorensen, Adam C.; Cortopassi, Jeffrey E., Transdermal dosage form for low-melting point active agent.
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  296. Kanios, David; Mantelle, Juan A.; Nguyen, Viet, Transdermal drug delivery device including an occlusive backing.
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  297. Kanios, David; Mantelle, Juan A.; Nguyen, Viet, Transdermal drug delivery device including an occlusive backing.
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  299. Kanios, David; Mantelle, Juan A.; Nguyen, Viet, Transdermal drug delivery device including an occlusive backing.
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  300. Mantelle, Juan, Transdermal estrogen device and delivery.
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  301. Mantelle, Juan, Transdermal estrogen device and delivery.
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  302. Mantelle, Juan, Transdermal estrogen device and delivery.
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  303. Mantelle, Juan, Transdermal estrogen device and delivery.
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  304. Altenschöpfer, Peter; Watkinson, Adam Charles, Transdermal granisetron.
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  305. Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Cacace, Janice Louise; Irani, Neda; Sancilio, Frederick D., Transdermal hormone replacement therapies.
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  306. Houze, David W.; Chan, Vincent Lau, Transdermal levonorgestrel device and delivery.
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  307. Patel, Kalpana J; Borsadia, Suresh, Transdermal method and patch for emesis.
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  308. Gale, Robert M.; Audett, Jay; Padmanabhan, Rama V.; Cormier, Michel J. N.; Luciano, Allison; Silverberg, Eric N.; Foreman, Paul B., Transdermal nicotine salt delivery system.
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  309. Gale, Robert M.; Audett, Jay; Padmanabhan, Rama V.; Cormier, Michel J. N.; Luciano, Allison; Silverberg, Eric N.; Foreman, Paul B., Transdermal nicotine salt delivery system.
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  310. Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
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  311. Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
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  312. Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
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  313. Zeltman, Jon, Transdermal patch and method for delivery of vitamin B12.
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  314. Gessa, Gian Luigi, Transdermal patch and topical compositions comprising propylnorapomorphine.
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