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A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the comming

A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

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A process for producing a material bearing thereon a coating of a wet, slippery, adhering, commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel, said process comprising: a) affixing reactive chemical functional groups, at least s

A process for producing a material bearing thereon a coating of a wet, slippery, adhering, commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel, said process comprising: a) affixing reactive chemical functional groups, at least some of which are amine-containing groups, to a surface of a hydrophilic or hydrophilicized hydrophobic polymer substrate or a metal substrate to make a reactive substrate surface; b) coating the resulting reactive substrate surface of (a) with a first coating comprising a hydrophilic polyurethane-urea prepolymer intermediate, which is capable of forming a polyurethane-polyurea hydrogel-forming polymer, and which contains terminal isocyanate groups, such that at least some of said terminal isocyanate groups are reacted with and are covalently bonded to said reactive chemical functional groups on said reactive substrate surface, forming covalent polyurea bonds therewith, resulting in the formation of a tie coat of a polyurethane-polyurea hydrogel-forming polymer, which adheres to said reactive substrate surface, and wherein at least some of said terminal isocyanate groups in said polyurethane-polyurea hydrogel-forming polymer remain free to react with other species; and c) treating said resulting tie coat of (b) with a treatment selected from the group (i-ii) consisting of: (i) applying a second coating comprising an aqueous solution of a poly(N-vinylpyrrolidone) hydrogel-forming polymer; and (ii) applying a second coating comprising an aqueous solution of a poly(N-vinylpyrrolidone) hydrogel-forming polymer, followed by application, in a vapor phase, of a moisture-containing substance, such that a barrier coat which is a commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) hydrogel is formed; wherein water of said aqueous solution or said moisture: containing substance is bound with said polyurethane-polyurea hydrogel-forming polymer forming said polyurethane-polyurea polymer hydrogel; wherein water of said aqueous solution or said moisture: containing substance is bound with said poly(N-vinylpyrrolidone) hydrogel-forming polymer forming said poly(N-vinylpyrrolidone) polymer hydrogel; and wherein said poly(N-vinylpyrrolidone) polymer hydrogel is adherent to said substrate surface as a result of being commingled with said polyurethane-polyurea polymer hydrogel.