초록 ▼

An improved apparatus for the iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane so the medication can be absorbed by the adjacent tissues and blood vessels. The apparatus can be adapted for large dermal area application or for a smal

An improved apparatus for the iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane so the medication can be absorbed by the adjacent tissues and blood vessels. The apparatus can be adapted for large dermal area application or for a smaller area of application, depending on the choice of specific electrode employed. The apparatus comprises a multichannel iontophoretic applicator electrode. Multiple piezoelectric elements are mounted on the ionotophoetic electrode. The combination of ultrasonic vibration and iontophoresis creates a significant improvement in the penetration of medicament in contact with the skin or mucous membrane underlying the electrode. Drug delivery systems employing biofeedback such as the transcutaneous delivery of insulin based on tissue glucose are outlined based on this ionosonic technology.

대표청구항 ▼

An ionosonic medicament applicator for use with a multichannel power source and adapted to be releasably attached to the skin of an organism for the transdermal delivery of medicament, comprising in combination: (a) a skin-contacting medicament containing layer; (b) a multichannel iontophoresis elec

An ionosonic medicament applicator for use with a multichannel power source and adapted to be releasably attached to the skin of an organism for the transdermal delivery of medicament, comprising in combination: (a) a skin-contacting medicament containing layer; (b) a multichannel iontophoresis electrode comprising at least three individual electrically isolated electrode channels, said iontophoresis electrode overlying said medicament containing layer and each of said individual electrically isolated electrode channels being in electrical communication with said medicament container layer; and (c) an ultrasonic electrode overlying said medicament containing layer and comprising at least one piezoelectric element in mechanical communication with said medicament containing layer, said at least one piezoelectric element being operable for producing ultrasonic mechanical vibrations in said skin-contacting medicament containing layer when energized by energizing means.