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Method for rapid temporal control of molecular transport across tissue 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-031/00
출원번호 US-0487470 (1995-06-07)
발명자 / 주소
  • Pliquett Uwe (Leipzig DEX) Prausnitz Mark R. (Dorchester MA) Weaver James C. (Sudbury MA) Langer Robert S. (Newton MA)
출원인 / 주소
  • Massachusetts Institute of Technology (Cambridge MA 02)
인용정보 피인용 횟수 : 57  인용 특허 : 10

초록

A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in re

대표청구항

A method for transdermally treating an organism in response to an intrinsic condition, comprising the steps of: a) applying a medication to epidermis of the organism; b) electroporating the epidermis at a first voltage pulse condition in response to said intrinsic condition to initiate delivery of t

이 특허에 인용된 특허 (10)

  1. Grasso Robert J. (Tampa FL), Apparatus and methods for performing electrofusion at specific anatomical sites.
  2. Calvin Noel M. (4201 Page Mill Rd. Los Altos CA 94022), Apparatus for the high efficiency transformation of living cells.
  3. Weaver James C. (Sudbury MA) Powell Kevin T. (Boston MA) Langer ; Jr. Robert S. (Newton MA), Control of transport of molecules across tissue using electroporation.
  4. Takahashi Yasuo (Drexelhill PA) Suzuki Kazuo (Stony Brook NY) Niimura Toshinobu (Port Jefferson NY) Kano Tokio (Nesconset NY), Device for electrofusion of cells.
  5. Glikfeld Peretz (San Francisco CA) Cullander Christopher (Berkeley CA) Hinz Robert S. (Mill Valley CA) Guy Richard H. (Daley City CA), Device for iontophoretic non-invasive sampling or delivery of substances.
  6. Ray F. Andrew (Los Alamos NM) Cram L. Scott (Los Alamos NM) Galey William R. (Albuquerque NM), Electromicroinjection of particles into living cells.
  7. Davis Charles P. (Galveston TX) Warren Michael M. (Galveston TX) Arnett David W. (Monrovia CA), Iontophoretic catheter device.
  8. Theeuwes Felix (Los Altos Hills CA) Gyory J. Richard (San Jose CA) Haak Ronald P. (San Jose CA), Layered electrotransport drug delivery system.
  9. McNichols Larry A. (Coon Rapids MN) Lattin Gary A. (Forest Lake MN), Method and apparatus for pulsed iontophoretic drug delivery.
  10. Geddes Leslie A. (West Lafayette IN) Hinds Marvin H. (Marion IN) Bourland Joe D. (West Lafayette IN) Voorhees William D. (West Lafayette IN), Method and apparatus for thermally destroying a layer of an organ.

이 특허를 인용한 특허 (57)

  1. Andino, Rafael Victor; Patel, Samirkumar R.; Zarnitsyn, Vladimir; Brooks, Christopher John, Apparatus and methods for drug delivery using multiple reservoirs.
  2. Andino, Rafael Victor; Zarnitsyn, Vladimir; Brooks, Christopher John; Kahute, Trent John; Arsenault, Justin William; Trettin, David Jackson; Bauer, Andrew Kent; Lewis, Stephanie Elaine, Apparatus and methods for ocular injection.
  3. Andino, Rafael Victor; Zarnitsyn, Vladimir; Brooks, Christopher John; Yoo, Jesse, Apparatus and methods for ocular injection.
  4. Andino, Rafael Victor; Zarnitsyn, Vladimir; Yoo, Jesse; Brooks, Christopher John; Kahute, Trent John; Arsenault, Justin William; Trettin, David Jackson; Bauer, Andrew Kent; Lewis, Stephanie Elaine, Apparatus and methods for ocular injection.
  5. Andino, Rafael Victor; Zarnitsyn, Vladimir; Yoo, Jesse; Brooks, Christopher John; Kahute, Trent John; Arsenault, Justin William; Trettin, David Jackson; Bauer, Andrew Kent; Lewis, Stephanie Elaine, Apparatus and methods for ocular injection.
  6. Andino, Rafael Victor; Zarnitsyn, Vladimir; Yoo, Jesse; Brooks, Christopher John; Kahute, Trent John; Arsenault, Justin William; Trettin, David Jackson; Bauer, Andrew Kent; Lewis, Stephanie Elaine, Apparatus and methods for ocular injection.
  7. Hofmann, Gunter A., Apparatus for electroporation mediated delivery for drugs and genes.
  8. Hofmann,Gunter A., Apparatus for electroporation mediated delivery for drugs and genes.
  9. Hofmann Gunter A., Apparatus for electroporation mediated delivery of drugs and genes.
  10. Weaver James C. ; Pliquett Uwe,DEX ; Vanbever Rita,BEX ; Gowrishankar Thiruvallur R. ; Zewert Thomas E., Biopotential measurement including electroporation of tissue surface.
  11. Walker Jeffrey P. ; Bernard Robert M., Drug delivery system and method.
  12. Nolan, Edward; Rabussay, Dietmar P.; Widera, Georg; Zhang, Lei, Electrical field therapy with reduced histopathological change in muscle.
  13. Nolan, Edward; Rabussay, Dietmar P.; Widera, Georg; Zhang, Lei, Electrical field therapy with reduced histopathological change in muscle.
  14. Bernard Robert M., Electrodes and electrode arrays for generating electroporation inducing electrical fields.
  15. Bernard Robert M., Electrodes and electrode arrays for generating electroporation inducing electrical fields.
  16. Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T.; Niemiec, Susan M., Electrotransort device comprising blades.
  17. Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T., Electrotransport delivery system comprising internal sensors.
  18. Ying Sun ; Ralph W. Oakeson ; Stephen J. Wisniewski ; Jonas C. T. Wang, Exothermic bandage.
  19. Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T., Exothermic topical delivery device.
  20. Ferek-Petric, Bozidar, Implantable electroporation therapy device and method for using same.
  21. Sexton, Frederick A.; Suni, Ian Ivar; Cetinkaya, Cetin; Schuckers, Stephanie; Sazonov, Eduard, Integrated intra-dermal delivery, diagnostic and communication system.
  22. Hofmann,Gunter A.; Rabussay,Dietmar P.; Zhang,Lei, Intradermal delivery of active agents by needle-free injection and electroporation.
  23. Weaver James C. ; Chen Tani ; Cullander Christopher ; Guy Richard,FRX ; Langer Robert S. ; Zewert Thomas E. ; Pliquett Uwe,DEX ; Vanbever Rita,BEX ; Prausnitz Mark R., Introduction of modifying agents into skin by electroporation.
  24. Weaver, James C.; Anderson, R. Rox; Herndon, Terry O; Gowrishankar, T. R.; Gift, Elizabeth A.; Gonzalez, Salvador, Localized molecular and ionic transport to and from tissues.
  25. Zhang Lei ; Hofmann Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
  26. Zhang, Lei; Hofmann, Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
  27. Bureau, Michel; Mir, Lluis; Scherman, Daniel, Method for transferring nucleic acid into multicelled eukaryotic organism cells and combination therefor.
  28. Bureau, Michel; Mir, Lluis; Scherman, Daniel, Method for transferring nucleic acid into striated muscles.
  29. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of electroporation mediated delivery of drugs and genes.
  30. Hofmann, Gunter A.; Rabussay, Dietmar P.; Zhang, Lei, Method of electroporation-enhanced delivery of active agents.
  31. Gill, Harvinder Singh; Prausnitz, Mark R., Method of making coated microstructures.
  32. Yuzhakov, Vadim V., Method of making microneedle array and device for applying microneedle array to skin.
  33. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of programming an array of needle electrodes for electroporation therapy of tissue.
  34. Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
  35. Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
  36. Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
  37. Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
  38. Zarnitsyn, Vladimir; Patel, Samirkumar; White, Daniel; Noronha, Glenn; Burke, Brian, Methods and devices for the treatment of ocular diseases in human subjects.
  39. Zarnitsyn, Vladimir; Patel, Samirkumar; White, Daniel; Noronha, Glenn; Burke, Brian, Methods and devices for the treatment of ocular diseases in human subjects.
  40. Zarnitsyn, Vladimir; Patel, Samirkumar; White, Daniel; Noronha, Glenn; Burke, Brian; Kissner, Jennifer, Methods and devices for the treatment of ocular diseases in human subjects.
  41. Chiang, Yu-Wei; Prausnitz, Mark R.; DeWitt, Kristopher Daniel; Arya, Jaya, Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus.
  42. Roy, Shuvo; Fleischman, Aaron J., Microneedle array module and method of fabricating the same.
  43. Roy,Shuvo; Fleischman,Aaron J., Microneedle array module and method of fabricating the same.
  44. Yuzhakov, Vadim V., Microneedle array, patch, and applicator for transdermal drug delivery.
  45. Weaver, James C.; Anderson, R. Rox; Herndon, Terry O., Microscission processes and procedures.
  46. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Minimally invasive apparatus and method to electroporate drugs and genes into tissue.
  47. Larry R. Brown ; Elazer Edelman ; David Tseng, Non-invasive transdermal detection of analytes.
  48. Dev, Nagendu B.; Hofmann, Gunter A.; Nolan, Edward; Rabussay, Dietmar P.; Tonnessen, Arnt; Widera, Georg; Zhang, Lei, Skin and muscle-targeted gene therapy by pulsed electrical field.
  49. Dev, Nagendu B.; Hofmann, Gunter A.; Nolan, Edward; Rabussay, Dietmar P.; Tonnessen, Arnt; Widera, Georg; Zhang, Lei, Skin and muscle-targeted gene therapy by pulsed electrical field.
  50. Viswanathan, Raju; Long, Gary; Pageard, Jean-Luc, Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue.
  51. Viswanathan, Raju; Zingeler, Allan; Long, Gary; Pageard, Jean-Luc, Systems, devices, and methods for focal ablation.
  52. Kollias,Nikiforos; Sun,Ying; Coston,Anthony F., Tissue ablation by shear force for sampling biological fluids and delivering active agents.
  53. Yuzhakov, Vadim V, Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection.
  54. Sun,Ying; Oakeson,Ralph W.; Wisniewski,Stephen J.; Wang,Jonas C. T., Tissue electroperforation for enhanced drug delivery.
  55. Coston,Anthony F.; Sun,Ying; Oakeson,Ralph W.; Wisniewski,Stephen J.; Wang,Jonas C. T., Tissue electroperforation for enhanced drug delivery and diagnostic sampling.
  56. Kwiatkowski,Krzysztof C.; Hayes,Ryan T.; Magnuson,James W.; Giletto,Anthony, Transdermal delivery of therapeutic agent.
  57. Andino, Rafael Victor; Brooks, Christopher John; Zarnitsyn, Vladimir; White, Harrison J., Variable diameter cannula and methods for controlling insertion depth for medicament delivery.
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