초록 ▼

A composition comprises an agent to be delivered through a body surface and an electrotransport enhancer having a hydrophobic tail and a polar head of specific characteristics. An electrotransport delivery device is also provided having a reservoir comprising the agent to be delivered and the electr

A composition comprises an agent to be delivered through a body surface and an electrotransport enhancer having a hydrophobic tail and a polar head of specific characteristics. An electrotransport delivery device is also provided having a reservoir comprising the agent to be delivered and the electrotransport enhancer of the invention. The electrotransport enhancers increase the electrotransport delivery rate of the agent through the surface while reducing the electrical resistance of the surface during electrotransport of the agent.

대표청구항 ▼

A composition for the transdermal electrotransport delivery of an agent comprising: a) at least one agent for transdermal delivery; and b) at least one transdermal electrotransport enhancer having a hydrophile-lipophile balance (HLB) number greater than about 6 and comprising a hydrophobic tail and

A composition for the transdermal electrotransport delivery of an agent comprising: a) at least one agent for transdermal delivery; and b) at least one transdermal electrotransport enhancer having a hydrophile-lipophile balance (HLB) number greater than about 6 and comprising a hydrophobic tail and a polar head of less than about 150 Dalton MW, the polar head group being uncharged or having a charge opposite the charge of the agent to be delivered if the agent is ionizable in solution; wherein the electrotransport enhancer is selected from the group consisting of saturated C10-C12 aliphatic alcohols, amines, mono- and di-substituted amines, quaternary ammonium salts, sulfoxides, sulfates, amides, mono- and di-substituted amides, esters and salts thereof.