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Composition for sustained release of non-aggregated erythropoietin 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/50
  • B32B-005/16
  • B01J-013/02
출원번호 US-0483318 (1995-06-07)
발명자 / 주소
  • Zale Stephen E. (Hopkington MA) Burke Paul A. (Medford MA) Bernstein Howard (Cambridge MA) Brickner Avram (Brookline MA)
출원인 / 주소
  • Alkermes, Inc. (Cambridge MA 02)
인용정보 피인용 횟수 : 58  인용 특허 : 15

초록 ▼

A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active,

대표청구항 ▼

A composition for the sustained release of biologically active, non-aggregated erythropoietin from a polymeric matrix, comprising: a) a biodegradable polymer; and b) particles of biologically active, aggregation-stabilized erythropoietin, wherein said particles include erythropoietin in contact with

이 특허에 인용된 특허 (15)

  1. Langer Robert S. (Somerville MA) Rosen Howard (Montara CA), Bioerodible polyanhydrides for controlled drug delivery.
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  2. Langer Robert S. (Somerville MA) Rosen Howard (Montara CA) Linhardt Robert J. (Iowa City IA) Leong Kam (Cambridge MA), Bioerodible polyanhydrides for controlled drug delivery.
    상세보기
  3. Hutchinson Francis G. (Lymm GBX), Continuous release pharmaceutical compositions.
    상세보기
  4. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
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  5. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Drug delivery system and method of making the same.
    상세보기
  6. Shimoda Naoto (Saitama JPX) Kawaguchi Tsutomu (Saitama JPX), Method and composition for preventing the adsorption of a medicine.
    상세보기
  7. Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
    상세보기
  8. Cynshi Osamu (Tokyo JPX) Mizuno Koji (Saitama JPX), Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis.
    상세보기
  9. Loomis Gary L. (Drexel Hill PA) Murdoch Joseph R. (Wilmington DE), Polylactide compositions.
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  10. Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기
  • Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules and their production.
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  • Woog Heinrich (Laudenbach DEX) Gruber Werner (Birkenau DEX) Markl Hans-Jrg (Ellerstadt DEX) Demmer Frtiz (Hirschberg-Leutershausen DEX), Stabilized erythropoietin preparations.
    상세보기
  • Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
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  • Silvestri Loui J. (Miramar FL) Pyle H. Ruth (Ft. Lauderdale FL), Sustained release dosage form.
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  • Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
    상세보기

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