초록 ▼

The combination of a phosphatase enzyme with a biocompatible carrier material produces materials which are useful in the repair of the skeleton and the promotion of new bone growth. The combination preferably involves covalent coupling between the enzyme and the carrier. The preferred carrier materi

The combination of a phosphatase enzyme with a biocompatible carrier material produces materials which are useful in the repair of the skeleton and the promotion of new bone growth. The combination preferably involves covalent coupling between the enzyme and the carrier. The preferred carrier materials include fibrillar collagen and may be obtained by the demineralization of calcified tissues. The materials may include phosphoproteins or dentinal phosphophoryns which may be residual or may be added during the preparation of the materials. The incorporation of other organophosphates and inorganic phosphates may improve the rate of mineralization especially in older animals.

대표청구항 ▼

A material which comprises a biocompatible carrier having a densely organized fibrous structure, said carrier comprising fibrillar collagen, in combination with a phosphatase (Apase) in an effective amount having an enzyme activity of at least 1.0 milliunit Apase per 1.0 microgram (ugm) of hydroxypr

A material which comprises a biocompatible carrier having a densely organized fibrous structure, said carrier comprising fibrillar collagen, in combination with a phosphatase (Apase) in an effective amount having an enzyme activity of at least 1.0 milliunit Apase per 1.0 microgram (ugm) of hydroxyproline for promoting in vivo mineralization of the material, said material further comprising an organophosphorus compound.