Norton Richard L. (Fort Collins CO) Knight Stephen Michael Gregory (Fort Collins CO) Tipton Arthur J. (Birmingham AL)
출원인 / 주소
Atrix Laboratories, Inc. (Fort Collins CO 02)
인용정보
피인용 횟수 :
176인용 특허 :
62
초록▼
The invention provides moldable, biodegradable composition for use with bone and other tissues. The composition comprises a poly(caprolactone) thermoplastic polymer processed alone or compounded with a biocompatible, biodegradable substance that controls crystallization of the polymer and functions
The invention provides moldable, biodegradable composition for use with bone and other tissues. The composition comprises a poly(caprolactone) thermoplastic polymer processed alone or compounded with a biocompatible, biodegradable substance that controls crystallization of the polymer and functions to soften the composition. The composition may further include a biologically-active agent such as an antibiotic for sustained delivery in an animal, a coloring agent for tinting the composition, and other additives as desired.
대표청구항▼
A biodegradable, pharmaceutical composition, consisting of: (a) a biodegradable poly(caprolactone) thermoplastic polymer having a weight average molecular weight of about 600-3000; and (b) a biodegradable, crystallization-controlling agent selected from the group consisting of calcium carbonate, hyd
A biodegradable, pharmaceutical composition, consisting of: (a) a biodegradable poly(caprolactone) thermoplastic polymer having a weight average molecular weight of about 600-3000; and (b) a biodegradable, crystallization-controlling agent selected from the group consisting of calcium carbonate, hydroxyapatite, calcium phosphate, calcium apatite, calcium sulfate, calcium bicarbonate, calcium chloride, sodium carbonate, sodium bicarbonate, sodium chloride, calcium stearate, calcium palmitate, sodium stearate, dextran, starch, sodium carboxymethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, poly(vinyl alcohol), glycerol palmitate, glycerol stearate, triethyl citrate, ethyl lactate, poly(ethylene glycol), poly(vinyl pyrrolidone), poly(lactide-co-caprolactone), and combinations thereof; wherein the composition contains the crystallization-controlling agent in an amount effective to maintain the poly(caprolactone) as a moldable mass wherein crystalline regions of the poly(caprolactone) polymer are substantially uniformly distributed throughout; and the composition has a spreadable consistency and is capable of adhering to and providing an effective amount of homeostasis in a bone defect.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (62)
Gall Rudi (Mannheim DEX) Bosies Elmar (Mannheim DEX), 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid, pharmaceutical compositions and methods of use.
Mattei Frank V. (Piscataway NJ) Stephenson Martin (Peterborough CAX) Gordon Allin K. (Peterborough CA CAX) Doddi Namassivaya (Upland CA), Absorbable hemostatic composition.
Mattei Frank V. (Piscataway NJ) Stephenson Martin (Peterborough CAX) Gordon Allin K. (Peterborough CA CAX) Doddi Namassivaya (Upland CA), Absorbable hemostatic composition.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David D. (Birmingham AL), Biodegradable in-situ forming implants and methods for producing the same.
Dunn Richard L. (451 Boardwalk Dr. RLD ; Apt. 501 Fort Collins CO 80526) English James P. (2500 Melinda Cir. Birmingham AL 35214) Cowsar Donald R. (4657 Round Forest Dr. Birmingham AL 35213) Vanderbi, Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David D. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David P. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable polymer composition.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
Benedict James J. (Cincinnati OH) Johnson Karen Y. (Cincinnati OH), Certain cycloalkane-1,1-diphosphonic acids and derivatives thereof having the ability to treat diseases associated with.
Kronenthal Richard L. (Fair Lawn NJ) Mattei Frank V. (Piscataway NJ) Levy Alan (Bridgewater NJ), Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition.
Kronenthal Richard L. (Fair Lawn NJ) Mattei Frank V. (Piscataway NJ) Levy Alan J. (Bridgewater NJ), Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition.
Caldwell Larry J. (Lawrence KS) Gardner Colin R. (Lawrence KS) Cargill Robyn C. (Lawrence KS), Drug delivery device which can be retained in the stomach for a controlled period of time.
Hudgin Donald Edward (Princeton Junction NJ) Blair Edgar Allan (Cranbury NJ), Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles.
Peterlik Meinrad (Vienna ATX) Hoffmann Oskar (Vienna ATX), IFN-gamma as an active substance for inhibiting and preventing degradation processes in bone.
Hayward Marshall A. (Lawrenceville NJ) Sabatucci Joseph P. (Plainsboro NJ) Jirkovsky Ivo L. (Plainsboro NJ) Lefebvre Yvon (Plainsboro NJ), Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Harkrader Ronald J. (Louisville CO) Rogers Jack A. (Fort Collins CO), Intragingival delivery systems for treatment of periodontal disease.
Feinmann Bernhard P. P. (18 ; Ch. William Barbey CH-1292 Chambery CHX) Martignoni Mario (Via Maria Adelaide 5 Rome ITX), Material and method for dentistry.
Tang Reginald T. (Warren NJ) Mares Frank (Whippany NJ) Boyle ; Jr. William J. (Parsippany NJ) Chiu Tin-Ho (Millburn NJ) Patel Kundabhai M. (Landing NJ), Medical devices fabricated from homopolymers and copolymers having recurring carbonate units.
Suzuki Yoshiki (Hino JPX) Ikura Hiroshi (Hino JPX) Yamashita Gentaro (Tachikawa JPX) Nagai Tsuneji (Taito JPX), Method of treating an injured part on the oral mucosa and the covering material for use thereof.
Kronenthal, Richard L., Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects.
Kronenthal, Richard L., Absorbable putty-like implants and methods for their use for mechanical hemostasis of bone and for the treatment of osseous defects.
Schwartz Herbert E. ; Blackmore John M., Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use i.
Schwartz Herbert E. ; Blackmore John M., Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions.
Schwartz Herbert E. ; Blackmore John M., Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions.
Schwartz Herbert E. ; Blackmore John M., Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions.
Asius, Jerome; Asius, Benedicte, Ceramic-based injectable implants which are used to fill wrinkles, cutaneous depressions and scars, and preparation method thereof.
Fritz, Ulf; Fritz, Olaf; Gordy, Thomas A.; Wojcik, Ronald; Blümmel, Jacques; Küller, Alexander, Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same.
Moseley, Jon P.; Carroll, Michael E.; McCanless, Jonathan D.; Schulz, Olaf; Fronk, Andy, Composite bone graft substitute cement and articles produced therefrom.
Moseley, Jon P.; Carroll, Michael E.; McCanless, Jonathan D.; Schulz, Olaf; Fronk, Andy, Composite bone graft substitute cement and articles produced therefrom.
Berg,Richard; Falcone,Samuel; Oppelt,William G.; Cortese,Stephanie M., Compositions of polyacids and polyethers and methods for their use as dermal fillers.
Schwartz, Herbert E.; Blackmore, John M.; Cortese, Stephanie M.; Oppelt, William G., Compositions of polyacids and polyethers and methods for their use in reducing adhesions.
Lidgren, Lars; Lundgren, Torgny; Arvidsson, Pär; Jönsson, Sven, Device for providing spongy bone with bone substitute and/or bone reinforcing material, bone substitute and/or bone reinforcing material and method.
Cole,Jantzen A.; Carroll,Michael E.; Moseley,Jon P.; Richelsoph,Kelly C., Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects.
Fritz, Ulf; Fritz, Olaf; Gordy, Thomas A.; Wojcik, Ronald; Blümmel, Jacques; Küller, Alexander, Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same.
Fritz, Ulf; Fritz, Olaf; Gordy, Thomas A.; Wojcik, Ronald; Blümmel, Jacques; Küller, Alexander, Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same.
Harder, Philipp; Fritz, Olaf; Fritz, Ulf, Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same.
Harder, Philipp; Fritz, Olaf; Fritz, Ulf, Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same.
Alexander, Harold; Ricci, John L.; Mamidwar, Sachin, Method for manufacturing particles for use in forming a resorbable implant for stimulating bone growth.
Donnelly, Lisa M.; Li, Yufu; Sullivan, Joan M.; Whittaker, Gregory R.; Yuan, J. Jenny, Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw.
Donnelly, Lisa M.; Li, Yufu; Sullivan, Joan M.; Whittaker, Gregory R.; Yuan, J. Jenny, Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw.
Donnelly, Lisa M.; Li, Yufu; Sullivan, Joan M.; Whittaker, Gregory R.; Yuan, J. Jenny, Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw.
Donnelly, Lisa; Li, Yufu; Sullivan, Joan M.; Whittaker, Gregory; Yuan, J. Jenny, Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw.
O'Keefe Regis James ; Rosier Randy Nathan, Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors.
Schobel, Alexander M.; Myers, Garry L.; Kendall, Keith Joseph; Rademacher, Thomas; Mous, Jan; Barry, Justin N. W.; Williams, Phillip; Barrientos, Africa Garcia, Nanoparticle film delivery systems.
Branham,Keith; Chaubal,Mahesh V.; English,James P.; Hall,Donna; Zhao,Zhong, Phosphorous-containing compounds with polymeric chains, and methods of making and using the same.
Branham, Keith; Chaubal, Mahesh V.; English, James P.; Hall, Donna; Zhao, Zhong, Phosphorus-containing compounds with polymeric chains, and methods of making and using the same.
Branham, Keith; Chaubal, Mahesh V.; English, James P.; Hall, Donna; Zhao, Zhong, Phosphorus-containing compounds with polymeric chains, and methods of making and using the same.
Miller, Mark E.; Cortese, Stephanie M.; Schwartz, Herbert E.; Oppelt, William G., Polyacid/polyalkylene oxide foams and gels and methods for their delivery.
Yang, Robert K.; Fuiz, Richard C.; Myers, Garry L.; Fuiz, Joseph M., Process for making a film having a substantially uniform distribution of components.
Myers, Garry L.; Hilbert, Samuel D.; Boone, Bill J.; Bogue, B. Arlie; Sanghvi, Pradeep; Hariharan, Madhusudan, Sublingual and buccal film compositions.
Myers, Garry L.; Hilbert, Samuel D.; Boone, Bill J.; Bogue, B. Arlie; Sanghvi, Pradeep; Hariharan, Madhusudan, Sublingual and buccal film compositions.
Grunze, Michael; Fritz, Ulf, Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Uniform films for rapid dissolve dosage form incorporating taste-masking compositions.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Uniform films for rapid dissolve dosage form incorporating taste-masking compositions.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.