초록 ▼

There is provided a water-in-oil (w/o) micro emulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby an water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microem

There is provided a water-in-oil (w/o) micro emulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby an water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion contains a preferred high purity short chain monoglyceride surfactant. The w/o microemulsion is particularly useful for storing proteins and the like for ling periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and release the protein.

대표청구항 ▼

A stable, water-in-oil microemulsion composition suitable for storage and administration of biologically active materials, comprising: (a) from about 5 to about 99 volume percent of an oil phase comprising at least one pharmaceutically acceptable oil; (b) up to about 60 volume percent of an aqueous

A stable, water-in-oil microemulsion composition suitable for storage and administration of biologically active materials, comprising: (a) from about 5 to about 99 volume percent of an oil phase comprising at least one pharmaceutically acceptable oil; (b) up to about 60 volume percent of an aqueous phase comprising water; (c) a biologically active material having a water:oil partition coefficient greater than 10:1; (d) from about 1 to about 70 volume percent of a mixture of surfactants having a combined HLB value of from about 7 to about 14 comprising (i) a low HLB surfactant having an HLB below 8, said low HLB surfactant being at least 80 percent by weight of a C9 monoglyceride, C10 monoglyceride, C11 monoglyceride, C12 monoglyceride, or C13 monoglyceride, and (ii) at least one surfactant having an HLB value above about 8.