[특허]Implantable system for delivery of fluid-sensitive agents to animals

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/02 A61K-009/22
출원번호	US-0485870 (1995-06-07)
발명자 / 주소	Magruder Judy A. (Mt. View CA) Eckenhoff deceased James B. (late of Los Altos CA by Bonnie J. Eckenhoff executrix ) Cortese Richard (Los Gatos CA) Wright Jeremy C. (Los Altos CA) Peery John R. (S
출원인 / 주소	Magruder et al. Judy A. (Mountain View CA 04)
인용정보	피인용 횟수 : 18 인용 특허 : 46

초록 ▼

A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall sectio

A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined “bursting”pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.

대표청구항 ▼

A device for delivering a beneficial agent to a fluid environment of use, the device comprising: a) a housing comprising a fluid impermeable wall section, the housing containing the beneficial agent; b) an exit passageway for fluidly connecting the housing interior to the environment of use; c) an e

A device for delivering a beneficial agent to a fluid environment of use, the device comprising: a) a housing comprising a fluid impermeable wall section, the housing containing the beneficial agent; b) an exit passageway for fluidly connecting the housing interior to the environment of use; c) an energy source for increasing pressure within the housing when the device is in the environment of use; d) a sealing material, adjacent the exit passageway, the material being effective to seal the exit passageway before the housing is pressurized, at least a portion of the material being expelled through the passageway after the housing is pressurized, thereby opening the exit passageway, thereafter allowing continuous release of a therapeutically effective amount of beneficial agent during the entire time of delivery.

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이 특허에 인용된 특허 (46) 인용/피인용 타임라인 분석

Saunders Richard J. (San Jose CA) Mefferd Wayne Sherman (Los Altos Hills CA), Apparatus for tracking moving workpiece by a laser beam.
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Churchill Jeffrey R. (Northwich GBX) Hutchinson Francis G. (Lymm GBX), Continuous release formulations.
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Theeuwes Felix (Los Altos CA) Wong Patrick S. L. (Palo Alto CA), Delayed release osmotically driven fluid dispenser.
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Balaban Stephen M. (Chesterfield MO) Pike James B. (St. Peters MO) Smith Jonathan P. (St. Louis MO) Baile Clifton A. (Chesterfield MO), Delivery devices with pulsatile effect.
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Magruder, Judy A.; Eckenhoff, James B.; Cortese, Richard; Wright, Jeremy C.; Peery, John R., Delivery system comprising two sections for delivering somatotropin.
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Eckenhoff James B. (Los Altos CA) Magruder Judy A. (Mt. View CA) Cortese Richard (Cupertino CA) Peery John R. (Palo Alto CA) Wright Jeremy C. (Los Altos CA), Device comprising means for protecting and dispensing fluid sensitive medicament.
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Theeuwes Felix (Los Altos CA), Device for dispensing drug by combined diffusional and osmotic operations.
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Theeuwes Felix (Los Altos CA), Device having variable volume chamber for dispensing useful agent.
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Michaels Alan S. (San Francisco CA), Device using hydrophilic polymer for delivering drug to biological environment.
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Manning James H. (Monroe NY) Stark John H. (Campbell Hall NY), Diester crosslinked polyglucan hydrogels and reticulated sponges thereof.
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Eckenhoff J. Benjamin (Los Altos CA) Theeuwes Felix (Los Altos CA) Deters ; Joseph C. (Mountain View CA), Dispenser for delivering thermo-responsive composition.
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Theeuwes Felix (Los Altos CA), Dispenser with diffuser.
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Eckenhoff James B. (Los Altos CA), Dispensing system for administering beneficial agent formulation to ruminants.
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Edgren David E. (El Granada CA) Bhatti Gurdish K. (Fremont CA) Carpenter Howard A. (Palo Alto CA), Dosage form comprising drug and maltodextrin.
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Stephens Sally I. (Mountain View CA) Wong Patrick S. L. (Hayward CA), Dosage form with improved delivery capability.
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Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA), Dosage system and method of using same.
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Ayer Atul D. (Palo Alto CA) Eckenhoff James B. (Los Altos CA) Wright Jeremy C. (Los Altos CA) Kuczynski Anthony L. (Palo Alto CA), Long-term delivery device including loading dose.
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Eckenhoff James B. (Los Altos CA), Means for providing instant agent from agent dispensing system.
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Eckenhoff James B. (Los Altos CA) Magruder Judy A. (Mt. View CA) Cortese Richard (Cupertino CA) Peery John R. (Palo Alto CA) Wright Jeremy C. (Los Altos CA), Method for delivering somatotropin to an animal.
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Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA), Method for establishing blood levels of biocide in animals.
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Maccecchini Maria-Luisa (Northbrook IL), Method of promoting animal growth using antibodies against somatostatin.
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Bentle Larry A. (St. Charles MO) Mitchell James W. (St. Louis MO) Storrs Stephen B. (St. Louis MO), Method of somatotropin naturation.
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Wong Patrick S. L. (Palo Alto CA) Theeuwes Felix (Los Altos CA) Eckenhoff James B. (Los Altos CA), Multi-layer delivery system.
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Wong Patrick S. L. (Palo Alto CA) Theeuwes Felix (Los Altos CA) Eckenhoff James B. (Los Altos CA) Larsen Steven D. (Dublin CA) Huynh Hoa T. (Fremont CA), Multi-unit delivery system.
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Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
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Wong Patrick S. L. (Hayward CA) Barclay Brian (Sunnyvale CA) Deters Joseph C. (Mt. View CA) Theeuwes Felix (Los Altos CA), Osmotic device with dual thermodynamic activity.
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Cortese Richard (San Jose CA) Theeuwes Felix (Los Altos CA), Osmotic device with hydrogel driving member.
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Theeuwes ; Felix ; Ayer ; Atul D., Osmotic devices having composite walls.
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Nakano Masahiro (Lawrence KS) Higuchi Takeru (Lawrence KS) Hussain Anwar (Lawrence KS), Osmotic dispenser.
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Higuchi Takeru (Lawrence KS) Leeper Harold M. (Mountain View CA), Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient.
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Theeuwes ; Felix, Osmotic system for the controlled and delivery of agent over time.
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Ayer Atul D. (Mountain View CA) Theeuwes Felix (Los Altos CA), Osmotic system with distribution zone for dispensing beneficial agent.
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Theeuwes ; Felix, Osmotic system with means for improving delivery kinetics of system.
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Theeuwes Felix (Los Altos CA), Osmotic system with volume amplifier for increasing amount of agent delivered therefrom.
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Balaban Stephen M. (Chesterfield MO) Pike James B. (St. Peters MO) Smith Jonathan P. (St. Louis MO) Baile Clifton A. (Chesterfield MO), Osmotically driven delivery devices with pulsatile effect.
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Eckenhoff James Benjamin (Palo Alto CA) Johnson Neil Arthur (Sunnyvale CA) Yum Su Il (Sunnyvale CA), Osmotically driven fluid dispenser.
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Theeuwes Felix (Los Altos CA) Wong Patrick S. L. (Palo Alto CA), Osmotically driven syringe.
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Yum Su I. (Los Altos CA), Osmotically driven syringe.
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Theeuwes ; Felix ; Saunders ; Richard J. ; Mefford ; Wayne S., Process for forming outlet passageways in pills using a laser.
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Ayer Atul D. (Mountain View CA) Theeuwes Felix (Los Altos CA), Process for manufacturing device with dispersion zone.
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Pope David G. (Branchburg NJ) Royce Alan E. (Somerset NJ), Pulsatile drug delivery system.
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Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA), Self controlled release device for administering beneficial agent to recipient.
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DePrince Randolph B. (Terre Haute IN) Viswanathan Ravi (Terre Haute IN), Stabilized porcine growth hormone.
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Theeuwes Felix (Los Altos CA), System with microporous releasing diffusor.
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Ayer Atul D. (Mt. View CA) Theeuwes Felix (Los Altos CA), Therapeutic device for osmotically dosing at controlled rate.
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Eckenhoff James B. (Los Altos CA), Water absorbing fluid dispenser.
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Gillis, Edward M.; Poutiatine, Andrew L.; Filice, James A.; Wickman, Peter; Culwell, John; Dinka, John S., Device and method for accurate delivery of an active agent.
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Alessi, Thomas R.; Leung, Karling Alice; Mercer, Ryan D.; Negulescu, Cristina G.; Rohloff, Catherine M.; Yang, Bing, Devices, formulations, and methods for delivery of multiple beneficial agents.
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Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
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Smith, Jay S.; Cole, Michael R.; Whitson, Amy K., Implant placement guide.
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Eliaz, Rom Ezer; Zhang, Yuanpeng; Rohloff, Catherine Manya; Weeks, Eric William; Junnarkar, Gunjan, Methods of manufacturing viscous liquid pharmaceutical formulations.
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Lautenbach, Scott D., Minimally compliant, volume efficient piston for osmotic drug delivery systems.
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Alessi, Thomas R.; Mercer, Ryan D.; Rohloff, Catherine M.; Yang, Bing, Osmotic delivery device comprising an insulinotropic peptide and uses thereof.
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Peterson, Lewis L.; Maruyama, Fred H.; Dehnad, Houdin; Hom, Lawton; Ly, Kevin S.; Davis, Craig R.; Peery, John R., Osmotic delivery system flow modulator apparatus and method.
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Peterson, Lewis L.; Maruyama, Fred H.; Dehnad, Houdin; Hom, Lawton; Ly, Kevin S.; Davis, Craig R.; Peery, John R., Osmotic delivery system flow modulator apparatus and method.
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Peterson,Lewis L.; Maruyama,Fred H.; Dehnad,Houdin; Hom,Lawton; Ly,Kevin S.; Davis,Craig R.; Peery,John R., Osmotic delivery system flow modulator apparatus and method.
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Chen Guohua ; Lautenbach Scott D. ; Dionne Keith E. ; Jordan Scott D. ; Berry Steve A. ; Rodenberger Craig I. ; Ayer Rupal, Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems.
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Chen, Guohua; Lautenbach, Scott D.; Dionne, Keith E.; Jordan, Scott D.; Berry, Steve A.; Rodenberger, Craig I.; Ayer, Rupal, Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems.
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Alessi, Thomas R.; Luskey, Kenneth, Rapid establishment and/or termination of substantial steady-state drug delivery.
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Rohloff, Catherine M.; Chen, Guohua; Luk, Andrew S.; Ayer, Rupal A.; Houston, Paul R.; Desjardin, Michael A.; Zamora, Pauline; Lam, Stan, Solvent/polymer solutions as suspension vehicles.
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Alessi, Thomas R.; Baron, Michelle, Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c.
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Lautenbach, Scott C.; De La Serna, Pedro E.; Zamora, Pauline C.; Desjardin, Michael A., Two-piece, internal-channel osmotic delivery system flow modulator.
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[미국특허] Implantable system for delivery of fluid-sensitive agents to animals 원문보기

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