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Transformed yeast cells expressing heterologous G-protein coupled receptor 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/81
출원번호 US-0195729 (1994-02-14)
발명자 / 주소
  • Pausch Mark Henry (Robbinsville NJ) Ozenberger Bradley A. (Yardley PA) Hadcock John Richard (Mount Holly NJ) Price Laura Alicia (Langhorne PA) Kajkowski Eileen Marie (Ringoes NJ) Kirsch Donald Richar
출원인 / 주소
  • American Cyanamid Company (Madison NJ 02)
인용정보 피인용 횟수 : 48  인용 특허 : 1

초록 ▼

A first aspect of the present invention is directed to a transformed yeast cell containing a first heterologous DNA sequence which codes for a G protein-coupled receptor, for example, the somatostatin receptor, and a second heterologous DNA sequence which codes for a G protein a

대표청구항 ▼

A transformed yeast cell comprising a reporter gene under control of a pheromone-responsive promoter, a heterologous protein-coupled receptor gene, each said gene being under the control of a separate promoter, and a gene mutation causing increased sensitivity to receptor activation selected from th

이 특허에 인용된 특허 (1)

  1. Sledziewski Andrzej Z. (Seattle WA) Sheppard Paul O. (Redmond WA), Methods of producing hybrid G protein-coupled receptors.
    상세보기

이 특허를 인용한 특허 (48)

  1. Cismowski,Mary; Duzic,Emir, AGS proteins and nucleic acid molecules and uses therefor.
    상세보기
  2. Madden Kevin T. ; Errada Patrick R. ; Gimeno Carlos J., Assay for agents which alter G-protein coupled receptor activity.
    상세보기
  3. Madden Kevin T. ; Errada Patrick R. ; Gimeno Carlos J., Assay for agents which alter G-protein coupled receptor activity.
    상세보기
  4. Xu, Jun; Trueheart, Joshua, Cell based signal generation.
    상세보기
  5. Xu,Jun; Trueheart,Joshua, Cell based signal generation.
    상세보기
  6. Manfredi,John P.; Benton,Benjamin K.; Wu,Meng Yu, Cell having amplified signal transduction pathway responses and uses therefor.
    상세보기
  7. Ostanin,Kirill; Cismowski,Mary; Silverman,Lauren, Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways.
    상세보기
  8. Ford, John; Yeung, George, Chemokine receptor obtained from a CDNA library of fetal liver-spleen.
    상세보기
  9. Ford,John; Yeung,George, Chemokine receptor obtained from a cDNA library of fetal liver-spleen.
    상세보기
  10. John Ford ; George Yeung, Chemokine receptor obtained from a cDNA library of fetal liver-spleen.
    상세보기
  11. Baron, Alain D.; Brown, Martin R.; Jones, Christopher R. G.; Fineman, Mark S., Chemosensory receptor ligand-based therapies.
    상세보기
  12. Baron, Alain; Brown, Martin R.; Jones, Christopher R. G., Chemosensory receptor ligand-based therapies.
    상세보기
  13. Baron, Alain; Brown, Martin R.; Jones, Christopher R. J., Chemosensory receptor ligand-based therapies.
    상세보기
  14. Li, Xiaodong; Staszewski, Lena; Xu, Hong, Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides.
    상세보기
  15. Li, Xiaodong; Staszewski, Lena; Xu, Hong, Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides.
    상세보기
  16. Li, Xiaodong; Staszewski, Lena; Xu, Hong, Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides.
    상세보기
  17. Shigemura, Rhondi; Chen, Qing; Darmohusodo, Vincent; Dean, Aaron R., Comestible compositions comprising high potency savory flavorants, and processes for producing them.
    상세보기
  18. Nadkarni,Anupama K.; Trueheart,Joshua, Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties.
    상세보기
  19. Tachdjian, Catherine; Patron, Andrew P.; Adamski-Werner, Sara L.; Bakir, Farid; Chen, Qing; Darmohusodo, Vincent; Hobson, Stephen Terrence; Li, Xiaodong; Qi, Ming; Rogers, Daniel H.; Rinnova, Marketa; Servant, Guy; Tang, Xiao-Qing; Zoller, Mark; Wallace, David; Xing, Amy; Gubernator, Klaus, Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof.
    상세보기
  20. Tachdjian, Catherine; Patron, Andrew P.; Adamski-Werner, Sara L.; Bakir, Farid; Chen, Qing; Darmohusodo, Vincent; Hobson, Stephen Terrence; Li, Xiaodong; Qi, Ming; Rogers, Daniel H.; Rinnova, Marketa; Servant, Guy; Tang, Xiao-Qing; Zoller, Mark; Wallace, David; Xing, Amy; Gubernator, Klaus, Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof.
    상세보기
  21. Citovsky, Vitaly H.; Rhee, Yoon, Genetic assay for protein nuclear transport.
    상세보기
  22. Pausch, Mark Henry; Ozenberger, Bradley Alton; Hadcock, John Richard; Price, Laura Alicia; Kajkowski, Eileen Marie; Kirsch, Donald Richard; Chaleff, Deborah Tardy, Heterologous G protein coupled receptors expressed in yeast, their fusion with G proteins and use thereof in bioassay.
    상세보기
  23. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., High throughput chemical handling system.
    상세보기
  24. Christopher Bentley Shumate ; Peter J. Coassin, Liquid chemical distribution method and apparatus.
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  25. Shumate,Christopher Bentley; Coassin,Peter J., Liquid chemical distribution method and apparatus.
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  26. Gratzer, Sabine; De Hoop, Meltsje; Mai, Bernhard, Method for identifying substances capable of modulating the activity of a target molecule.
    상세보기
  27. Klein,Christine A.; Murphy,Andrew J. M.; Fowlkes,Dana M.; Broach,James; Manfredi,John; Paul,Jeremy; Trueheart,Joshua, Methods and compositions for identifying receptor effectors.
    상세보기
  28. Klein,Christine A.; Murphy,Andrew J.; Fowlkes,Dana M.; Broach,James; Manfredi,John; Paul,Jeremy; Trueheart,Joshua, Methods and compositions for identifying receptor effectors.
    상세보기
  29. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Methods for rapidly identifying useful chemicals in liquid sample.
    상세보기
  30. Joann Strnad ; John R. Hadcock, Nucleic acid encoding human neurotensin subtype 2 receptor.
    상세보기
  31. Negulescu Paul ; Offermanns Stefan,DEX ; Simon Melvin ; Zuker Charles, Promiscuous G-protein compositions and their use.
    상세보기
  32. Oehlen, Lambertus J., System for detection of a functional interaction between a compound and a cellular signal transduction component.
    상세보기
  33. Oehlen,Lambertus J., System for detection of a functional interaction between a compound and a cellular signal transduction component.
    상세보기
  34. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  35. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  36. Stylli Chari ; Beckey Samuel S. ; Shumate Christopher Bentley ; Coassin Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  37. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
    상세보기
  38. Li, Xiaodong; Staszewski, Lena; Xu, Hong, T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds.
    상세보기
  39. Li, Xiaodong; Staszewski, Lena; Xu, Hong, Use of T1R3 venus flytrap region polypeptide to screen for taste modulators.
    상세보기
  40. Fowlkes,Dana M.; Broach,James R.; Manfredi,John P.; Klein,Christine A.; Murphy,Andrew J. M.; Paul,Jeremy I.; Trueheart,Joshua, Yeast cells engineered to produce pheromone system protein surrogates and uses therefor.
    상세보기
  41. Fowlkes Dana Merriman ; Broach Jim ; Manfredi John ; Klein Christine ; Murphy Andrew J. ; Paul Jeremy ; Trueheart Joshua, Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor.
    상세보기
  42. Fowlkes, Dana M.; Broach, Jim; Manfredi, John; Klein, Christine; Murphy, Andrew J.; Paul, Jeremy; Trueheart, Joshua, Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor.
    상세보기
  43. Fowlkes,Dana M.; Broach,Jim; Manfredi,John; Klein,Christine; Murphy,Andrew J.; Paul,Jeremy; Trueheart,Joshua, Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor.
    상세보기
  44. Fowlkes,Dana M.; Broach,Jim; Manfredi,John; Klein,Christine; Murphy,Andrew J.; Paul,Jeremy; Trueheart,Joshua, Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor.
    상세보기
  45. Fowlkes, Dana M.; Broach, James R.; Manfredi, John P.; Paul, Jeremy I.; Trueheart, Joshua; Klein, Christine A.; Murphy, Andrew J. M., Yeast cells expressing modified G proteins and methods of use therefor.
    상세보기
  46. Fowlkes,Dana M.; Broach,James R.; Manfredi,John P.; Paul,Jeremy I.; Trueheart,Joshua; Klein,Christine A.; Murphy,Andrew J. M., Yeast cells expressing modified G proteins and methods of use therefor.
    상세보기
  47. Ostanin Kirill ; Silverman Lauren, Yeast cells having mutations in Cav1 and uses therefor.
    상세보기
  48. Kirill Ostanin ; Lauren Silverman, Yeast cells having mutations in stp22 and uses therefor.
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