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Polysaccharide-bound nitric oxide-nucleophile adducts 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/785
  • C08B-015/06
  • C08B-037/00
출원번호 US-0419424 (1995-04-10)
발명자 / 주소
  • Smith Daniel J. (Stow OH) Chakravarthy Debashish (Garrettsville OH) Keefer Larry K. (Bethesda MD)
출원인 / 주소
  • The United States of America as represented by the Department of Health and Human Services (Washington DC 06)
인용정보 피인용 횟수 : 73  인용 특허 : 19

초록 ▼

A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N2O2-functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitr

대표청구항 ▼

A polymeric composition capable of releasing nitric oxide, said composition comprising a polysaccharide including a nitric oxide-releasing [N2O2]functional group selected from the group consisting of XN(O)NO]and [N(O)NOX, wherein X is an amine-group-containing moiety bonded to said N(O)NO]or [N(O)NO

이 특허에 인용된 특허 (19)

  1. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof.
    상세보기
  2. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Antihypertensive compositions and use thereof.
    상세보기
  3. Hutsell Thomas C. (North Oaks MN), Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents.
    상세보기
  4. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Complexes of nitric oxide with polyamines.
    상세보기
  5. Nolan Mary E. (Topsfield MA) Kosek John A. (Danvers MA) La Conti Anthony B. (Lynnfield MA), Gas sensing and measuring device and process using catalytic graphite sensing electrode.
    상세보기
  6. Inskip Ervin B. (Troy IL) Patane Joseph M. (Manchester MO), Inhibiting polymerization of ethylenically unsaturated monomers.
    상세보기
  7. Ciccone Joseph P. (Davis CA) DeCastro Emory S. (Emeryville CA) Kerr John B. (Oakland CA), Macrocyclic amine complexes for ligand extraction and generation.
    상세보기
  8. Lipton Stuart A. (Newton MA), Method of preventing NMDA receptor complex-mediated neuronal damage.
    상세보기
  9. Christodoulou Danae D. (Frederick MD) Wink ; Jr. David A. (Hagerstown MD) Keefer Larry K. (Bethesda MD), Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents.
    상세보기
  10. Bedell Stephen A. (Lake Jackson TX), Nitric oxide abatement with polymeric cobalt(III) chelates.
    상세보기
  11. Shaffer Joel E. (Chapel Hill NC) Thomson Stephen A. (Durham NC), Oxathi(SIV)azol-5-one compounds.
    상세보기
  12. Keefer Larry K. (Bethesda MD) Dunams Tambra M. (Florence AL) Saavedra Joseph E. (Thurmont MD), Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs.
    상세보기
  13. Conboy James J. (Ithaca NY) Hotchkiss Joseph H. (Ithaca NY), Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds.
    상세보기
  14. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
    상세보기
  15. Keith Alec D. (Miami FL), Polymeric diffusion matrix containing propranolol.
    상세보기
  16. Loeppky Richard N. (Columbia MO) Bao Yen T. (Columbia MO), Polymers for scavenging nitrosating agents.
    상세보기
  17. Grinstead Robert R. (Walnut Creek CA), Process for the removal of NO from fluid streams using a water-soluble polymeric chelate of a polyvalent metal.
    상세보기
  18. Ohta Tomohisa (Tochigi JPX) Hagiwara Hiroyuki (Shimodate JPX) Kanbara Hisashige (Shimodate JPX) Dobashi Akihiko (Shimodate JPX) Seki Yasuyuki (Hitachi JPX), Radiation curable pressure sensitive adhesive composition.
    상세보기
  19. Keefer Larry K. (Bethesda MD), Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents.
    상세보기

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  2. Fossel, Eric T., Beneficial effects of increasing local blood flow.
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  3. Saavedra Joseph E. ; Keefer Larry K. ; Roller Peter P. ; Akamatsu Miki, Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same.
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  4. Stolen, Craig, Bispecific antibodies and agents to enhance stem cell homing.
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  5. Daniel J. Smith ; Sibel Yazici TR, Chitosan-based nitric oxide donor compositions.
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  6. Smith Daniel J. ; Serhatkulu Sibel, Chitosan-based nitric oxide donor compositions.
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  7. McDonald,William F.; Koren,Amy B.; Dourado,Sunil K.; Dulebohn,Joel I.; Hanchar,Robert J., Conductive polymer-based material.
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  8. Peters, Tor, Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor.
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  9. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  10. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  11. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  12. Carbone, Phil; Benedek, Karen; Ruffo, Michael O.; Luongo, Wade, Device and method for gas sterilization.
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  13. Carbone, Phil; Benedek, Karen; Ruffo, Michael O.; Luongo, Wade, Device and method for gas sterilization.
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  14. Peters, Tor, Device, method, and use for treatment of neuropathy involving nitric oxide.
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  15. Fitzhugh, Anthony L.; Cafferata, Robert; Keefer, Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
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  16. Fitzhugh,Anthony L.; Cafferata,Robert; Keefer,Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
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  17. Smith Daniel J. ; Rao Weisun, Hydrolytically unstable, biocompatible polymer.
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  18. Reynolds, Melissa M.; Damodaran, Vinod B., Materials for modulating biological responses and methods of making.
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  19. Beaulieu, Andre; Paquin, Robert, Method of producing concentrated non-buffered solutions of fibronectin.
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  20. Stolen, Craig, Methods and devices to regulate stem cell homing.
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  21. Bauman, Susanne; Stasko, Nathan A., Methods of decreasing sebum production in the skin.
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  22. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Methods of inhibiting xanthine oxidase activity in a cell.
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  23. Joseph E. Saavedra ; Larry K. Keefer ; Peter P. Roller ; Miki Akamatsu, Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same.
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  24. Schoenfisch, Mark; Riccio, Daniel; Nugent, Julia; Stasko, Nathan, Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same.
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  25. Hrabie, Joseph A.; Citro, Michael L.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof.
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  26. Hrabie, Joseph A.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated compounds.
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  27. Keefer,Larry K.; Hrabie,Joseph A., Nitric oxide-releasing medical devices.
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  28. Fitzhugh Anthony L. ; Cheng Peiwen ; Saavedra Joseph ; Cafferata Robert ; Hendriks Marc,NLX ; Keefer Larry K. ; Tedeschi Eugene ; Verhoeven Michel L. P. M.,NLX, Nitric oxide-releasing metallic medical devices.
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  29. Fitzhugh, Anthony L.; Cheng, Peiwen; Saavedra, Joseph; Cafferata, Robert; Hendriks, Marc; Keefer, Larry K.; Tedeschi, Eugene; Verhoeven, Michel I. P. M., Nitric oxide-releasing metallic medical devices.
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  30. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing molecules.
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  31. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing molecules.
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  32. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  33. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  34. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  35. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  36. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  37. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing polymers.
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  39. Saavedra,Joseph E; Keefer,Larry K, O-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1, 2-diolates.
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  40. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Rice, William G.; Ji, Xinhua; Bogdan, Christian, O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates.
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  41. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Bogdan, Christian; Rice, William G.; Ji, Xinhua, O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates.
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  42. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
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  49. Chen, Changyi; Lu, Jian-Ming; Yao, Qizhi, Small molecule xanthine oxidase inhibitors and methods of use.
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  50. Beaulieu,Andre; Paquin,Robert; Lariviere,Benoit, Solid wound healing formulations containing fibronectin.
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  51. Smith, Daniel J., Stabilization and ionic triggering of nitric oxide release.
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  53. Schoenfisch, Mark; Riccio, Daniel, Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same.
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