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Humanized monoclonal antibodies against human interleukin-4 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
  • C07K-016/24
  • C07K-016/42
  • C07H-021/04
출원번호 US-0704744 (1996-09-06)
국제출원번호 PCT/US95/024 (1995-03-08)
§371/§102 date 19960906 (19960906)
국제공개번호 WO-9524481 (1995-09-14)
발명자 / 주소
  • Dalie Barbara
  • Miller Kenneth
  • Murgolo Nicholas
  • Tindall Stephen
출원인 / 주소
  • Schering Corporation
대리인 / 주소
    Dulak
인용정보 피인용 횟수 : 68  인용 특허 : 0

초록

Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Single-chain binding proteins, fusion proteins, and antigenic or IL-4 binding fragments of such antibodies are also provided b

대표청구항

[ What is claimed is:] [1.] A humanized monoclonal antibody or fragment thereof that specifically binds human IL-4 comprising a light or heavy chain variable region having a mature amino acid sequence shown in SEQ ID NO: 70 and SEQ ID NO: 79, respectively. [4.] An anti-idiotypic antibody or fragment

이 특허를 인용한 특허 (68)

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  2. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL 13 antibodies and uses thereof.
  3. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL13 antibodies and uses thereof.
  4. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL13 antibodies and uses thereof.
  5. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL13 antibodies and uses thereof.
  6. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL13 antibodies and uses thereof.
  7. Fung, Sek Chung; Moyle, Matthew; Lu, Mason; Yan, Changning; Singh, Sanjaya; Huang, Dan, Anti-IL13 antibodies and uses thereof.
  8. Lowman, Henry B.; Presta, Leonard G.; Jardieu, Paula M.; Lowe, John, Anti-IgE antibodies.
  9. Lowman, Henry B.; Presta, Leonard G.; Jardieu, Paula M.; Lowe, John, Anti-IgE antibodies.
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  15. Kasaian, Marion T.; Tchistiakova, Lioudmila Gennadievna; Veldman, Geertruida Machteld; Marquette, Kimberly Ann; Tan, Xiang-Yang; Donaldson, Debra D.; Lin, Laura Long; Shane, Tania; Tam, Amy Sze Pui; Feyfant, Eric; Wood, Nancy L.; Fitz, Lori J.; Widom, Angela M.; Parris, Kevin D.; Goldman, Samuel J.; Saldanha, Jose W., Antibodies against human interleukin-13 and uses therefor.
  16. Rao, Ercole; Mikol, Vincent; Li, Danxi; Kruip, Jochen; Davison, Matthew, Antibodies that bind IL-4 and/or IL-13 and their uses.
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  19. Krumlauf, Robb; Ellies, Debra, Antibodies that specifcally bind Sost and Wise peptides.
  20. Yusibov, Vidadi; Mett, Vadim; Musiychuck, Konstantin; Skarjinskaia, Marina, Bacillus anthracis antigens, vaccine compositions, and related methods.
  21. Ramakrishnan,Vanitha; Powers,David; Johnson,Dale E.; Jeffry,Ursula; Bhaskar,Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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  23. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  24. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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  27. Gunawan, Feny; Hsiao, Yi-Chun; Krawitz, Denise C.; Lin, Margaret S.; Vanderlaan, Martin; Vij, Rajesh; Yuk, Inn H.; Zhu-Shimoni, Judith, Compositions and methods for detecting and quantifying host cells protein in cell lines and recombinant polypeptide products.
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  31. Schreiber, Taylor H., Human TNFRSF25 antibody.
  32. Carballido Herrera, José M.; De Vries, Jan E.; Schwaerzler, Christoph, Human monoclonal antibodies against human IL-4.
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  62. Lowman, Henry B.; Presta, Leonard G.; Jardieu, Paula M.; Lowe, John, Therapeutic compositions comprising anti-IGE antibodies and immunosuppressive agent.
  63. Fung, Sek Chung; Moyle, Matthew, Treatment of cancer with a novel anti-IL13 monoclonal antibody.
  64. Fung, Sek Chung; Moyle, Matthew, Treatment of cancer with novel anti-IL13 monoclonal antibodies.
  65. Knapp, Elisabeth; Yusibov, Vidadi, Trypanosoma antigens, vaccine compositions, and related methods.
  66. Ramakrishnan, Vanitha; Bhaskar, Vinay; Ho, Sun; Murray, Richard; Law, Debbie, Use of anti-α5β1 antibodies to inhibit cancer cell proliferation.
  67. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Yersinia pestis antigens, vaccine compositions, and related methods.
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