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Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/00
  • C07F-009/02
출원번호 US-0560540 (1995-11-17)
발명자 / 주소
  • Ravikumar Vasulinga T.
출원인 / 주소
  • ISIS Pharmaceuticals, Inc.
대리인 / 주소
    Woodcock Washburn Kurtz Mackiewicz & Norris LLP
인용정보 피인용 횟수 : 43  인용 특허 : 0

초록

Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.

대표청구항

[ What is claimed is:] [1.] A compound having the Formula VII: EQU A--X.sub.1 --CH.sub.2 --CH.dbd.CH--CH.sub.2 --Z VII rein:X.sub.1 is O or S;A is (R.sub.7) (R.sub.8)P--;R.sub.8 is R.sub.5, or has the Formula X: [ STR 17 ] wherein: each R.sub.1, is, independently, H, --OH, --F, --O--X.sub.3 --D;X.su

이 특허를 인용한 특허 (43)

  1. Phillip Dan Cook ; Haoyun An ; Tingmin Wang ; Muthiah Manoharan, C3'-methylene hydrogen phosphonate monomers and related compounds.
  2. Cook, Phillip Dan; Manoharan, Muthiah; Maier, Martin; An, Haoyun, C3'-methylene hydrogen phosphonate oligomers and related compounds.
  3. Cook, Phillip Dan; Manoharan, Muthiah; Maier, Martin; An, Haoyun, C3′ -methylene hydrogen phosphonate oligomers and related compounds.
  4. Kyriacos C. Nicolaou, Carbopeptoids and carbo-nucleotoids.
  5. Nicolaou Kyriacos C., Carbopeptoids and carbonucleotoids.
  6. Capaldi,Daniel C.; Gaus,Hans Joachim Josef; Rentel,Claus Andre Frank; Olsen,Philip Dmitri; Kurata,Christine C.; Song,Quanlai, Compounds and methods for the characterization of oligonucleotides.
  7. Lakshman, Mahesh K.; Bae, Suyeal, Convertible nucleoside derivatives.
  8. Verthelyi, Daniela; Beaucage, Serge L.; Grajkowski, Andrzej, CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods.
  9. Skubatch, Hanna, Crystalline and amorphous forms of peptide.
  10. Sinha,Nanda D., Method of preventing modification of synthetic oligonucleotides.
  11. Skubatch, Hanna, Method of treating condition in animal.
  12. Skubatch, Hanna, Methods and compositions for modulating conditions in both mammals and plants.
  13. Skubatch, Hanna, Methods and compositions for treating conditions.
  14. Skubatch, Hanna, Methods and compositions for treating conditions.
  15. Skubatch, Hanna, Methods and compositions for treating conditions.
  16. Moser, Michael James, Methods for detection and typing of nucleic acids.
  17. Moser, Michael James, Methods for detection and typing of nucleic acids.
  18. Moser, Michael James, Methods for detection and typing of nucleic acids.
  19. Skubatch, Hanna, Methods for modulating activities in plants.
  20. Krotz,Achim H.; Ravikumar,Vasulinga T., Methods for synthesis of oligonucleotides.
  21. Dellinger,Douglas J.; Caruthers,Marvin H.; Betley,Jason R., Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection.
  22. Perbost Michel G. M. ; Kanemoto Roy H., Minimization of blooming in high-density arrays by using reactive wash reagents.
  23. Beaucage, Serge L.; Wilk, Andrzej; Grajkowski, Andrzej, N-acylphosphoramidites and their use in oligonucleotide synthesis.
  24. Prudent, James R.; Johnson, Scott C.; Moser, Michael J.; Marshall, David J., Nucleic acid amplification using non-standard bases.
  25. Ravikumar, Vasulinga T.; Capaldi, Daniel C.; Cole, Douglas L., Oligomer phosphoramidite compositions and processes for synthesizing the same.
  26. Guzaev Andrei P. ; Manoharan Muthiah, Phosphate and thiophosphate protecting groups.
  27. Moser, Michael James; Marshall, David J.; Prudent, James R.; Van Hout, Christopher V.; Larsen, Christine A., Polymerase inhibitor and method of using same.
  28. Moser, Michael James; Marshall, David J.; Prudent, James R.; Van Hout, Cristopher V.; Larsen, Christine A., Polymerase inhibitor and method of using same.
  29. Mellor,Ben James; Wellings,Donald Alfred; Douglas,Mark Edward, Process for the preparation of phosphorothioate oligonucleotides.
  30. Capaldi Daniel C. ; Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.
  31. Capaldi Daniel C. ; Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.
  32. Ravikumar Vasulinga T., Process for the synthesis of oligomeric compounds.
  33. Ravikumar Vasulinga T., Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds.
  34. Shamblee,Dwight; Wo,Shiming; Wang,Bing, Process of making phosphordiamidite compounds.
  35. Ross,Bruce; Song,Quanlai, Process of purifying phosphoramidites.
  36. Ravikumar, Vasulinga T.; Capaldi, Daniel C.; Cole, Douglas L., Processes for the synthesis of oligomers using phosphoramidite compositions.
  37. K철ster,Hubert; W철rl,Ralf, Solution phase biopolymer synthesis.
  38. K철ster,Hubert; W철rl,Ralf, Solution phase biopolymer synthesis.
  39. Dellinger,Douglas J.; Perbost,Michael G. M.; Caruthers,Marvin H.; Betley,Jason R., Synthesis of polynucleotides using combined oxidation/deprotection chemistry.
  40. Beaucage, Serge L; Chmielewski, Marcin K, Thermolabile hydroxyl protecting groups and methods of use.
  41. Beaucage,Serge L.; Grajkowski,Andrzej; Wilk,Andrzej, Thermolabile hydroxyl protecting groups and methods of use.
  42. Beaucage, Serge L.; Wilk, Andrzej; Grajkowski, Andrzej, Thermolabile phosphorus protecting groups, associated intermediates and methods of use.
  43. Gut Ivo Glynne,DEX ; Franzen Jochen,DEX, Two-step method of DNA amplification for MALDI-TOF measurement.
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