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Composition and method for the controlled release of metal cation-stabilized interferon 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/10
  • A61K-009/16
출원번호 US-0279784 (1994-07-25)
발명자 / 주소
  • Tracy Mark A.
  • Bernstein Howard
  • Khan M. Amin
출원인 / 주소
  • Alkermes Controlled Therapeutics, Inc.
대리인 / 주소
    Hamilton, Brook, Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 35  인용 특허 : 12

초록 ▼

The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the pol

대표청구항 ▼

[ The invention claimed is:] [1.] A composition for the controlled release of interferon from a polymeric matrix, comprising:a) a biocompatible polymer; andb) particles of metal cation-complexed interferon, wherein said particles are dispersed within the biocompatible polymer and are in the substant

이 특허에 인용된 특허 (12)

  1. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
    상세보기
  2. Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL), Drug delivery system and method of making the same.
    상세보기
  3. Yim Zachary (Paramus NJ) Zupon Martin (Basking Ridge NJ) Chaudry Imtiaz (Denville NJ), Insoluble copper-alpha interferon complex.
    상세보기
  4. Grossberg Sidney E. (Whitefish Bay Milwaukee WI) Sedmak Joseph J. (Milwaukee WI), Interferon stabilization.
    상세보기
  5. Reichert Paul (Montville NJ) McNemar Charles (Basking Ridge NJ) Nagabhushan Nagamani (Parsippany NJ) Nagabhushan Tattanahalli L. (Parsippany NJ) Tindall Stephen (Madison NJ) Hruza Alan (Hackettstown , Metal-interferon-alpha crystals.
    상세보기
  6. Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
    상세보기
  7. Fong Jones W. (Parsippany NJ), Processes for preparation of microspheres.
    상세보기
  8. Weissmann Charles (Zurich CHX), Recombinant DNA molecules and their use in producing human interferon-like polypeptides.
    상세보기
  9. Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
    상세보기
  10. Silvestri Loui J. (Miramar FL) Pyle H. Ruth (Ft. Lauderdale FL), Sustained release dosage form.
    상세보기
  11. Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
    상세보기
  12. Yim, Zachary; Zupon, Michael A.; Chaudry, Imtiaz A., Zinc-protamine-alpha interferon complex.
    상세보기

이 특허를 인용한 특허 (35)

  1. Bobo,John S.; Quintero,Julian A.; Jonn,Jerry Y.; Barefoot,Joe B.; Clark,Jeffrey G.; Narang,Upvan; Cannizaro,Scott Marc; Marmo,J. Christopher, Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto.
    상세보기
  2. Bechet, Anne Chantal; Van Dijkhuizen-Radersma, Riemke; Stigter, Martin; Bezemer, Jeroen Mattijs, Controlled release compositions for interferon based PEGT/PBT block copolymers and method for preparation thereof.
    상세보기
  3. Tracy, Mark A.; Bernstein, Howard; Khan, M. Amin, Controlled release of metal cation-stabilized interferon.
    상세보기
  4. Kim, Kyekyoon; Singh, Ravindra Pratap, Electrohydrodynamic spraying system.
    상세보기
  5. Brodbeck Kevin J. ; Gaynor-Duarte Ann T. ; Shen Theodore Tao-Ian, Gel composition and methods.
    상세보기
  6. Brodbeck, Kevin J.; Gaynor-Duarte, Ann T.; Shen, Theodore Tao-Ian, Gel composition and methods.
    상세보기
  7. Kevin J. Brodbeck ; Ann T. Gaynor-Duarte ; Theodore Tao-Ian Shen, Gel composition and methods.
    상세보기
  8. Brodbeck Kevin J. ; Shen Theodore T., Injectable depot gel composition and method of preparing the composition.
    상세보기
  9. Chern, Rey T.; Zingerman, Joel R., Liquid polymeric compositions for controlled release of bioactive substances.
    상세보기
  10. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
    상세보기
  11. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
    상세보기
  12. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
    상세보기
  13. Costantino, Henry R.; Bonassar, Lawrence J.; Tracy, Mark A., Method of generating cartilage.
    상세보기
  14. Dasch, James R.; Riley, M. Gary I., Method of modifying the release profile of sustained release compositions.
    상세보기
  15. Dasch,James R.; Riley,M. Gary I., Method of modifying the release profile of sustained release compositions.
    상세보기
  16. Costantino Henry R. ; Jaworowicz Warren E. ; Tracy Mark A. ; Beganski Christopher P., Method of producing sub-micron particles of biologically active agents and uses thereof.
    상세보기
  17. Henry R. Costantino ; Warren E. Jaworowicz ; Mark A. Tracy ; Christopher P. Beganski, Method of producing sub-micron particles of biologically active agents and uses thereof.
    상세보기
  18. Mark A. Tracy ; Kevin L. Ward ; Warren E. Jaworowicz, Method of producing submicron particles of a labile agent and use thereof.
    상세보기
  19. Tracy, Mark A.; Ward, Kevin L.; Jaworowicz, Warren E., Method of producing submicron particles of a labile agent and use thereof.
    상세보기
  20. Mark A. Tracy ; John D. Herberger ; Paul A. Burke ; Paul F. Herbert, Methods for fabricating polymer-based controlled release devices.
    상세보기
  21. Tracy Mark A. ; Herberger John D. ; Burke Paul A. ; Herbert Paul F., Methods for fabricating polymer-based controlled release devices.
    상세보기
  22. Staas, Jay K.; Tice, Thomas R.; Hudson, Bruce W.; Tipton, Arthur J., Methods for manufacturing delivery devices and devices thereof.
    상세보기
  23. Mark A. Tracy ; Kevin L. Ward ; David S. Scher ; J. Keith Johnson, Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins.
    상세보기
  24. Kim, Kyekyoon; Choi, Hyungsoo; Choy, Young Bin, Microparticles.
    상세보기
  25. Kim, Kyekyoon; Pack, Daniel W.; Berkland, Cory, Microparticles.
    상세보기
  26. Kim,Kyekyoon; Choi,Hyungsoo; Choy,Young Bin, Microparticles.
    상세보기
  27. Kim,Kyekyoon; Pack,Daniel W.; Berkland,Cory, Microparticles.
    상세보기
  28. Gefter Malcolm L. ; Barker Nicholas ; Musso Gary ; Molineaux Christopher J., Pharmaceutical formulations for sustained drug delivery.
    상세보기
  29. Gefter Malcolm L. ; Barker Nicholas ; Musso Gary ; Molineaux Christopher J., Pharmaceutical formulations for sustained drug delivery.
    상세보기
  30. Gefter, Malcolm L.; Barker, Nicholas; Musso, Gary; Molineaux, Christopher J., Pharmaceutical formulations for sustained drug delivery.
    상세보기
  31. Biggs, Danielle; Nettles, Heather, Process for preparing microparticles having a low residual solvent volume.
    상세보기
  32. Jaworowicz Warren E. ; Wright James I., Process for the preparation of polymer-based sustained release compositions.
    상세보기
  33. Warren E. Jaworowicz ; James I. Wright, Process for the preparation of polymer-based sustained release compositions.
    상세보기
  34. Igari Yasutaka,JPX ; Yamagata Yutaka,JPX, Sustained-release preparation.
    상세보기
  35. Yasutaka Igari JP; Yutaka Yamagata JP; Satoshi Iinuma JP; Hiroaki Okada JP; Kazumichi Yamamoto JP, Sustained-release preparation.
    상세보기

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