초록 ▼

Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical agent(s) in the carrier and a clay, and methods of administering the pharmaceutical agents to a mammal

Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical agent(s) in the carrier and a clay, and methods of administering the pharmaceutical agents to a mammal are disclosed.

대표청구항 ▼

[ What is claimed is:] [1.] A flexible, finite, bioadhesive composition for topical application comprising:(a) a therapeutically effective amount of at least one pharmaceutically active agent;(b) a pharmaceutically acceptable solvent for the pharmaceutically active agent and a plasticizer;(c) in adm

[ What is claimed is:] [1.] A flexible, finite, bioadhesive composition for topical application comprising:(a) a therapeutically effective amount of at least one pharmaceutically active agent;(b) a pharmaceutically acceptable solvent for the pharmaceutically active agent and a plasticizer;(c) in admixture with the pharmaceutically active agent in the solvent, a pharmaceutically acceptable bioadhesive carrier in an amount from about 5 to 50 percent based on the weight of the whole composition; and(d) a cohesive increasing amount of a clay;wherein the composition is substantially free of water, substantially water insoluble and is a bioadhesive; and wherein the pharmaceutically active agent is present in non-crystallized form in the composition.