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특허 상세정보

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Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is a

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) G01N-033/536    G01N-033/541    G01N-033/566    C07K-016/30   
미국특허분류(USC) 435/071 ; 435/075 ; 435/079 ; 435/079.1 ; 435/079.2 ; 436/501 ; 436/536 ; 436/538 ; 436/540 ; 436/542 ; 436/547 ; 530/387.7 ; 530/389.7
출원번호 US-0467083 (1995-06-06)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Seed and Berry LLP
인용정보 피인용 횟수 : 86  인용 특허 : 9
초록
▼

Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, ...

대표
청구항
▼

[ We claim:] [1.] A method of screening for the presence of a malignancy in a warm-blooded animal, wherein a HER-2/neu oncogene is associated with the malignancy, comprising the steps of:(a) contacting a body fluid, suspected of containing antibodies specific for HER-2/neu protein, with HER-2/neu protein;(b) incubating the body fluid under conditions and for a time sufficient to allow immunocomplexes to form; and(c) detecting the presence or absence of immunocomplexes formed between the HER-2/neu protein and antibodies in the body fluid specific for the ...

이 특허에 인용된 특허 (9)

  1. Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA). Antibody steric hindrance immunoassay with two antibodies. USP1976013935074.
  2. Carney Walter P. (North Andover MA) McKenzie Sara J. (Lynn MA). Detection and quantification of neu related proteins in the biological fluids of humans. USP1995035401638.
  3. Uzgiris Egidijus E. (Schenectady NY). Electrophoretic method of detecting antigen-antibody reaction. USP1976103984533.
  4. Gordon Julian (Arlesheim CHX) Staehelin Theophil (Arlesheim CHX) Towbin Harry (Allschwil CHX). Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays. USP1984064452901.
  5. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA). Fluorescence quenching with immunological pairs in immunoassays. USP1976123996345.
  6. Cheever, Martin A.; Peace, David J.. Immune reactivity to expressed activated oncogenes for diagnosis of malignancy. USP1994065320947.
  7. Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA). Reagents and method employing channeling. USP1980114233402.
  8. Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E.. Reverse sandwich immunoassay. USP1978074098876.
  9. Miles Laughton E. M. (Stanford CA). Universal reagent 2-site immunoradiometric assay using labelled anti (IgG). USP1977074034074.

이 특허를 인용한 특허 피인용횟수: 86

  1. Fendly,Brian M.. Anti-ErbB2 antibodies. USP2008057371376.
  2. Kim, Phillip; Liu, Xinjun; Kirkland, Richard; Lee, Tani; Ybarrondo, Belen; Singh, Sharat. Biomarkers for determining sensitivity of breast cancer cells to HER2-targeted therapy. USP2017089726669.
  3. Robertson,John Forsyth Russell; Graves,Catherine Rosemund; Price,Michael Rawling; Price,Frances Margaret. Cancer detection method and reagents. USP2007047205117.
  4. Kaumaya, Pravin. Chimeric peptides comprising HER-2 B-cell epitopes and T-helper epitopes. USP2013068470333.
  5. Kaumaya, Pravin. Chimeric peptides comprising HER-2 B-cell epitopes and Tcell helper epitopes. USP2016099452204.
  6. Grillo-López, Antonio J.. Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibodies. USP2016039296821.
  7. Grillo-Lopez, Antonio J.. Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody. USP20181010113000.
  8. Grillo-López, Antonio J.. Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody. USP2012128329172.
  9. Schultes, Birgit C.; Nicodemus, Christopher F.; Noujaim, Antoine A.; Madiyalakan, Ragupathy. Combination therapy for treating disease. USP2011108038994.
  10. Marzetta, Michael. Construction system. USP2009047517270.
  11. Mass, Robert D.. Detection of ErbB2 gene amplification to increase the likelihood of the effectiveness of ErbB2 antibody breast cancer therapy. USP2011087993834.
  12. Baughman, Sharon A.; Shak, Steven. Dosages for treatment with anti-ErbB2 antibodies. USP2003096627196.
  13. Baughman,Sharon A.; Shak,Steven. Dosages for treatment with anti-ErbB2 antibodies. USP2008057371379.
  14. Mass, Robert D.. Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy. USP2013058440402.
  15. Mass, Robert D.. Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy. USP2011128076066.
  16. Mass, Robert D.. Gene detection assay for improving the likelihood of an effective response to an EGFR antagonist cancer therapy. USP2013118592152.
  17. Cheever, Martin A.; Gheysen, Dirk. HER-2/neu fusion proteins. USP2013108568733.
  18. Cheever,Martin A.; Gheysen,Dirk. HER-2/neu fusion proteins. USP2007047198920.
  19. Cheever,Martin A.; Gheysen,Dirk. HER-2/neu fusion proteins. USP2008057375091.
  20. Cheever,Martin A.; Gheysen,Dirk. Her-2/neu fusion proteins. USP2007067229623.
  21. Adams, Camellia W.; Presta, Leonard G.; Sliwkowski, Mark. Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies. USP2009057537931.
  22. Adams, Camellia W.; Presta, Leonard G.; Sliwkowski, Mark. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies. USP2011017862817.
  23. Sliwkowski, Mark. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies. USP2005096949245.
  24. Humphreys, Robert; Xu, Minzhen. Ii-key/HER-2/neu hybrid cancer vaccine. USP2014118889143.
  25. Robertson, John F. R.; Murray, Andrea; Chapman, Caroline; Barnes, Anthony. Immunoassay methods. USP2015018927223.
  26. Robertson, John F. R.; Murray, Andrea; Chapman, Caroline; Barnes, Anthony. Immunoassay methods. USP2013118574848.
  27. Robertson, John Forsyth Russell; Barnes, Anthony; Murray, Andrea; Chapman, Caroline. Immunoassay methods. USP2017079714938.
  28. Robertson, John Forsyth Russell; Barnes, Anthony; Murray, Andrea; Chapman, Caroline. Immunoassay methods. USP2017089719984.
  29. Robertson, John Forsyth Russell; Barnes, Anthony; Murray, Andrea; Chapman, Caroline. Immunoassay methods. USP2014058722339.
  30. Pravin, Kaumaya. Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use. USP2016119504738.
  31. Sherman,Linda A.. In vivo activation of tumor-specific cytotoxic T cells. USP2008077402314.
  32. Bacus, Sarah S.; Lynch, David Haskett; Lockbaum, Pamela; Schwab, Gisela; Yang, Xiao-dong. Method for predicting response to epidermal growth factor receptor-directed therapy. USP2010087771958.
  33. Cohen, Robert L.; Gardiner, Mary Beth; Sliwkowski, Mark X.; Stelzer, Gregory T.. Methods for tissue analysis. USP2010037674589.
  34. Cohen,Robert L.; Gardiner,Mary Beth; Sliwkowski,Mark X.; Stelzer,Gregory T. Methods for tissue analysis. USP2008127468252.
  35. Marzetta,Michael; Broxson,Kriston M.; Wilson,Levi R.. Multi-part links for endless track. USP2008087410225.
  36. Kanner, Steven B.; Raitano, Arthur B.; Jakobovits, Aya; Challita Eid, Pia M.; Ge, Wangmao; Perez Villar, Juan J.. Nucleic acids and corresponding proteins entitled 254P1D6B useful in treatment and detection of cancer. USP2009127638270.
  37. Raitano, Arthur B.; Jakobovits, Aya; Challita-Eid, Pia M.; Ge, Wangmao; Perez-Villar, Juan J.; Kanner, Steven B.. Nucleic acids and corresponding proteins entitled 254P1D6B useful in treatment and detection of cancer. USP2013068460881.
  38. Kaumaya, Pravin. Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein. USP2012028110657.
  39. Kaumaya, Pravin T. P.. Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein. USP2010027666430.
  40. Kaumaya,Pravin T. P.; Stevens,Vernon C.; Triozzi,Pierre L.. Polypeptides and polynucleotides for enhancing immune reactivity to HER-2 protein. USP2006067060284.
  41. Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Shire, Steven J.; Yang, Janet Yu-Feng; Wu, Sylvia Sau-Yan. Protein formulation. USP2016039283273.
  42. Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Shire, Steven J.; Yang, Janet Yu-Feng; Wu, Sylvia Sau-Yan. Protein formulation. USP2010037682609.
  43. Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Shire, Steven J.; Yang, Janet Yu-Feng; Wu, Sylvia Sau-Yan. Protein formulation. USP2004026685940.
  44. Andya,James; Cleland,Jeffrey L.; Hsu,Chung C.; Lam,Xanthe M.; Overcashier,David E.; Shire,Steven J.; Yang,Janet Yu Feng; Wu,Sylvia Sau Yan. Protein formulation. USP2006067060268.
  45. Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Yang, Janet Yu-Feng. Protein formulation. USP2004116821515.
  46. Subjeck, John R.; Henderson, Robert A.; Repasky, Elizabeth A.; Kazim, Latif; Wang, Xiang-Yang. Stress protein compositions and methods for prevention and treatment of cancer and infectious disease. USP2011077976846.
  47. Subjeck,John R.; Henderson,Robert A.; Repasky,Elizabeth A.; Kazim,Latif; Wang,Xiang Yang. Stress protein compositions and methods for prevention and treatment of cancer and infectious disease. USP2006016984384.
  48. Ponniah, Sathibalan; Peoples, George E.; Storrer, Catherine E.; Flora, Michael. Targeted identification of immunogenic peptides. USP2015028945573.
  49. Ponniah, Sathibalan; Peoples, George E.; Storrer, Catherine E.; Flora, Michael. Targeted identification of immunogenic peptides. USP2014118883164.
  50. Ponniah, Sathibalan; Peoples, George E; Storrer, Catherine E; Flora, Michael. Targeted identification of immunogenic peptides. USP2017089720000.
  51. Ponniah, Sathibalan; Peoples, George E; Storrer, Catherine E; Flora, Michael. Targeted identification of immunogenic peptides. USP2015069050322.
  52. Cheung, Nai-Kong V.. Therapy-enhancing glucan. USP2010047704973.
  53. Cheung, Nai-Kong V.. Therapy-enhancing glucan. USP2016119480700.
  54. Cheung, Nai-Kong V.. Therapy-enhancing glucan. USP2014018633170.
  55. Cheung, Nai-Kong V.. Therapy-enhancing glucan. USP2014078791252.
  56. Cheung, Nai-Kong V.; Engstad, Rolf Einar. Therapy-enhancing glucan. USP2012128323644.
  57. Cheung, Nai-Kong V.; Engstad, Rolf Einar. Therapy-enhancing glucan. USP2015129211304.
  58. Cohen, Robert L.; Gardiner, Mary Beth; Sliwkowski, Mark X.; Stelzer, Gregory T.. Tissue analysis and kits therefor. USP2003066573043.
  59. Cohen, Robert L.; Gardiner, Mary Beth; Sliwkowski, Mark X.; Stelzer, Gregory T.. Tissue analysis and kits therefor. USP2005066905830.
  60. Cohen,Robert L.; Gardiner,Mary Beth; Sliwkowski,Mark X.; Stelzer,Gregory T.. Tissue analysis and kits therefor. USP2006107129051.
  61. Cohen,Robert L.; Gardiner,Mary Beth; Sliwkowski,Mark X.; Stelzer,Gregory T.. Tissue analysis and kits therefor. USP2008037344840.
  62. Andya, James; Hsu, Chung C.; Shire, Steven J.; Wu, Sylvia Sau-Yan. Treating a mammal with a formulation comprising an antibody which binds IgE. USP2015119180189.
  63. Sliwkowski,Mark X.. Treating prostate cancer with anti-ErbB2 antibodies. USP2006057041292.
  64. White, Christine; Grillo-Lopez, Antonio. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody. USP2013108557244.
  65. White, Christine A.; Grillo-Lopez, Antonio J.; Curd, John G.; Desmond-Hellmann, Susan. Treatment of chronic lymphocytic leukemia using anti-CD20 antibodies. USP2012068206711.
  66. White, Christine A.; Grillo-Lopez, Antonio J.. Treatment of diffuse large-cell lymphoma with anti-CD20 antibody. USP2014098821873.
  67. White, Christine A.; Grillo-Lopez, Antonio J.. Treatment of diffuse large-cell lymphoma with anti-CD20 antibody. USP2016119504744.
  68. White, Christine A.; Grillo-López, Antonio J.; Curd, John G.; Desmond-Hellmann, Susan. Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-CD20 antibody. USP2010037682612.
  69. Baughman, Sharon A.; Shak, Steven. Treatment with anti-ErbB2 antibodies. USP20181210160811.
  70. Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2010127846441.
  71. Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2012118309087.
  72. Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2013048425908.
  73. Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2011128075892.
  74. Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2014028642036.
  75. Paton, Virginia E.; Shak, Steven; Hellmann, Susan D.. Treatment with anti-ErbB2 antibodies. USP2011027892549.
  76. Sliwkowski, Mark. Treatment with anti-ErbB2 antibodies and EGFR-targeted drugs. USP2009117618631.
  77. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark. Treatment with anti-ErbB2 antibodies and anti-hormonal compounds. USP2009037498030.
  78. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark. Treatment with anti-ErbB2 antibodies and chemotherapeutic agents. USP2009027485302.
  79. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark. Treatment with anti-ErbB2 antibody combinations. USP2009037501122.
  80. Robertson, John Forsyth Russell; Graves, Catherine Rosamund Louise. Tumour marker proteins and uses thereof. USP2013118592169.
  81. Robertson, John F. R.; Graves, Catherine R. L.; Price, Michael R.. Tumour markers. USP2017079696319.
  82. Robertson, John F. R.; Graves, Catherine R. L.; Price, Michael R.; Price, legal representative, Frances Margaret. Tumour markers. USP2012028114604.
  83. Robertson,John F. R.; Graves,Catherine R. L.; Price, legal representative,Frances M.; Price,Michael R.. Tumour markers. USP2008077402403.
  84. Peoples, George; Ponniah, Sathibalan. Vaccine for the prevention of breast cancer recurrence. USP2017089737596.
  85. Peoples, George; Ponniah, Sathibalan. Vaccine for the prevention of breast cancer recurrence. USP2015089114099.
  86. Marzetta, Michael; Wilson, Levi R.; Broxson, Kriston M.. Vehicle axle joint for a toy vehicle. USP2010117841923.

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