초록 ▼

A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine, or an agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partia

A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine, or an agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or an agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or agonist while there is a substantial amount of the drug or agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or agonist thereof. In another embodiment, the drug or agonist is first administered and the antagonist is self-administered by a subject in a manner which mimics the use of the drug thereby counter-conditioning the drug user to the stimuli associated with the normal administration of the drug. The invention further provides a method of therapeutically treating psychophysiologic diseases and disorders involving neuronal dysregulation. The method additionally provides a pharmacologic composition for the treatment and reduction of drug dependence and which relies upon a combination of an agonist and an antagonist.

대표청구항 ▼

[ Having thus described our invention, what we desire to claim and secure by letters patent is:] [1.] A method of therapeutically treating physiological or psychophysiological dysfunction resulting from dysregulation in which certain receptors of a subject are over-active or under-active due to the

[ Having thus described our invention, what we desire to claim and secure by letters patent is:] [1.] A method of therapeutically treating physiological or psychophysiological dysfunction resulting from dysregulation in which certain receptors of a subject are over-active or under-active due to the action of an endogenous substance in the subject having such dysregulation and thereby resulting in the over-activity or under-activity, said method comprising simultaneously administering to a subject a composition comprised of a first component which is a drug or agonist of the drug and which causes receptors which are responsive to a systemic introduction of that activating drug to become activated, and a second component comprised of an antagonist to the drug or agonist which blocks effects of the drug or agonist that causes activation of these same receptors and which same receptors are also sensitive to the antagonist, the first component being administered in an amount which would improve the physiological or psychophysiological dysfunction resulting from under-activity of those receptors affected by the neurotransmitter and the endogenous substances by increasing the activity of such receptors by activating them, the second component being administered in an amount which improves the physiological or psychophysiological dysfunction resulting from over-activity of said receptors by decreasing activity of the receptors by blocking them, both the drug or agonist and the antagonist being administered in an effective amount to reduce the systemic effects of each other, counter the physiological or psychophysiological dysfunction and reduce over-activity or under-activity in said receptors caused by the endogenous substance.