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Photolabile compounds and methods for their use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07C-020/556
출원번호 US-0493877 (1995-06-23)
발명자 / 주소
  • Holmes Christopher P.
출원인 / 주소
  • Affymax Technologies N.V., GB2
대리인 / 주소
    Stevens
인용정보 피인용 횟수 : 61  인용 특허 : 7

초록

Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.

대표청구항 ▼

[ What is claimed is:] [1.] A compound having the formula: [ STR 18 ] wherein, R.sup.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, aryl or arylalkyl; R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.1 -C.sub.8 alkoxy; X.sup.11 is selected from the group consist

이 특허에 인용된 특허 (7)

  1. Venuti Michael C. (San Francisco CA), (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase in.
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  2. Hamill Brendan J. (11 ; Napier Square Livingston EH54 5DG GB6), Apparatus for the chemical synthesis of oligonucleotides.
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  3. Guillet James E. (31 Sagebrush Lane Don Mills ; Ontario CAX M3A 1X4) Bakhtiyari Hamid (29 Rowe Court Markham ; Ontario CAX L3S 2J6), Drug delivery systems.
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  4. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
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  5. Venuti Michael C. (San Francisco CA) Bruno John J. (Redwood City CA), Novel w 상세보기
  • Nagase Hiroshi (Tokyo JPX), Process for producing water-absorbing resins.
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  • Ellman Jonathan A. (Berkeley CA), Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support.
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    • 이 특허를 인용한 특허 (61)

    1. Jacobson, Joseph; Chu, Larry Li-Yang, Assembly of high fidelity polynucleotides.
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    2. Jacobson, Joseph; Chu, Larry Li-Yang, Assembly of high fidelity polynucleotides.
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    3. Smythe, Mark Leslie; Meutermans, Wim Denis Frans, Auxiliary for amide bond formation.
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    4. Toro, Esteban; Treusch, Sebastian; Chen, Siyuan; Wu, Cheng-Hsien, Compositions and methods for synthetic gene assembly.
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    5. Lukhtanov, Eugeny A., Compounds and methods for fluorescent labeling.
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    6. Lukhtanov, Eugeny A.; Vorobiev, Alexei V.; Reed, Michael W.; Vermeulen, Nicolaas M. J., Compounds and methods for fluorescent labeling.
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    7. Lukhtanov, Eugeny A.; Vorobiev, Alexei V.; Reed, Michael W.; Vermeulen, Nicolaas M. J., Compounds and methods for fluorescent labeling.
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    8. Lukhtanov, Eugeny A.; Vorobiev, Alexei V.; Reed, Michael W.; Vermeulen, Nicolaas M. J., Compounds and methods for fluorescent labeling.
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    9. Lukhtanov,Eugeny A.; Vorobiev,Alexei V.; Reed,Michael W.; Vermeulen,Nicolaas M. J., Compounds and methods for fluorescent labeling.
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    10. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    11. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    12. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    13. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    14. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    15. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre, De novo synthesized gene libraries.
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    16. Cox, Anthony; Chen, Siyuan, De novo synthesized nucleic acid libraries.
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    17. Gao,Xiaolian; Zhou,Xiaochuan; Gulari,Erdogan, Device for chemical and biochemical reactions using photo-generated reagents.
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    18. Banyai, William; Peck, Bill James; Fernandez, Andres; Chen, Siyuan; Indermuhle, Pierre; Marsh, Eugene P., Devices and methods for oligonucleic acid library synthesis.
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    19. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Dry deposition of materials for microarrays using matrix displacement.
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    20. Franch, Thomas; Lundorf, Mikkel Dybro; Jacobsen, Søren Nyboe; Olsen, Eva Kampmann; Andersen, Anne Lee; Holtmann, Anette; Hansen, Anders Holm; Sørensen, Anders Malling; Goldbech, Anne; de Leon, Daen; Kaldor, Ditte Kievsmose; Sløk, Frank Abildgaard; Husemoen, Gitte Nystrup; Dolberg, Johannes; Jensen, Kim Birkebæ; Pedersen, Lene; Nørregaard-Madsen, Mads; Godskesen, Michael Anders; Glad, Sanne Schrøder; Neve, Søren; Thisted, Thomas; Kronborg, Tine Titilola Akinleminu; Sams, Christian Klarner; Felding, Jakob; Freskgård, Per-Ola; Gouliaev, Alex Haahr; Pedersen, Henrik, Enzymatic encoding methods for efficient synthesis of large libraries.
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    21. Peck, Bill James; Indermuhle, Pierre; Marsh, Eugene P.; Fernandez, Andres; Stern, David, Functionalized surfaces and preparation thereof.
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    22. Blake, William J., Iterative nucleic acid assembly using activation of vector-encoded traits.
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    23. Butler, John H.; Brennan, Thomas M., Method and apparatus for in situ synthesis on a solid support.
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    24. Brennan, Thomas M.; Chatelain, Francois; Berninger, Mark, Method and apparatus for performing large numbers of reactions using array assembly with releasable primers.
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    25. Freskgard, Per-Ola; Gouliaev, Alex Haahr; Thisted, Thomas; Olsen, Eva Kampmann, Method for producing second-generation library.
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    26. Gouliaev, Alex Haahr; Franch, Thomas, Method for selecting a chemical entity from a tagged library.
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    27. Pedersen, Henrik; Holtmann, Anette; Franch, Thomas; Gouliaev, Alex Haahr; Felding, Jakob, Method for synthesising templated molecules.
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    28. Freskgard, Per-Ola; Franch, Thomas; Gouliaev, Alex Haahr; Lundorf, Mikkel Dybro; Felding, Jakob; Olsen, Eva Kampmann; Holtmann, Anette; Jakobsen, Soeren Nyboe; Sams, Christian Klarner; Glad, Sanne Schroeder; Jensen, Kim Birkebaek; Pedersen, Henrik, Method for the synthesis of a bifunctional complex.
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    29. Freskgard, Per-Ola; Franch, Thomas; Gouliaev, Alex Haahr; Lundorf, Mikkel Dybro; Felding, Jakob; Olsen, Eva Kampmann; Holtmann, Anette; Jakobsen, Soeren Nyboe; Sams, Christian Klarner; Glad, Sanne Schroeder; Jensen, Kim Birkebaek; Pedersen, Henrik, Method for the synthesis of a bifunctional complex.
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    30. Freskgard, Per-Ola; Franch, Thomas; Gouliaev, Alex Haahr; Lundorf, Mikkel Dybro; Felding, Jakob; Olsen, Eva Kampmann; Holtmann, Anette; Jakobsen, Soeren Nyboe; Sams, Christian Klarner; Glad, Sanne Schroeder; Jensen, Kim Birkebaek; Pedersen, Henrik, Method for the synthesis of a bifunctional complex.
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    31. Freskgard, Per-Ola; Franch, Thomas; Gouliaev, Alex Haahr; Lundorf, Mikkel Dybro; Felding, Jakob; Olsen, Eva Kampmann; Holtmann, Anette; Jakobsen, Soeren Nyboe; Sams, Christian Klarner; Schrøder Glad, Sanne; Jensen, Kim Birkebaek; Pedersen, Henrik, Method for the synthesis of a bifunctional complex.
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    32. Jacobson, Joseph; Church, George; Chu, Larry Li-Yang, Methods and devices for high fidelity polynucleotide synthesis.
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    33. Jacobson, Joseph; Church, George; Chu, Larry Li-Yang, Methods and devices for high fidelity polynucleotide synthesis.
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    34. Jacobson, Joseph; Ramu, Senthil; Schindler, Daniel, Methods and devices for in situ nucleic acid synthesis.
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    35. Jacobson, Joseph; Chu, Larry Li-Yang; Ramu, Senthil, Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly.
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    36. Jacobson, Joseph; Schindler, Daniel, Methods for nucleotide sequencing and high fidelity polynucleotide synthesis.
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    37. Kung, Li-yun A.; Schindler, Daniel; Jacobson, Joseph, Methods for preparative in vitro cloning.
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    38. Wu, Chao-ting; Church, George M., Methods for sequencing nucleic acid molecules.
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    39. Wu, Chao-ting; Church, George M., Methods for sequencing nucleic acid molecules.
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    40. Jacobson, Joseph; Goldberg, Martin J.; Kung, Li-yun A.; Schindler, Daniel; Hudson, Michael E., Methods for sorting nucleic acids and multiplexed preparative in vitro cloning.
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    41. Wu, Chao-ting; Beliveau, Brian, Methods of making oligonucleotide probes.
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    42. Oleinikov, Andrew V., Microarray synthesis and assembly of gene-length polynucleotides.
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    43. Oleinikov, Andrew V., Microarray synthesis and assembly of gene-length polynucleotides.
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    44. Oleinikov, Andrew V., Microarray synthesis and assembly of gene-length polynucleotides.
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    45. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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    46. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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    47. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
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    48. Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
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    49. Chu, Larry Li-Yang, Microfluidic devices and methods for gene synthesis.
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    50. Chu, Larry Li-Yang, Microfluidic devices and methods for gene synthesis.
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    51. Tran Vinh D. ; Ma Vu Van ; Liu Ruiyan, Photocleavable and acid cleavable linkers for combinatorial chemistry.
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    52. Tran, Vinh D.; Ma, Vu Van; Liu, Ruiyan, Photocleavable and acid cleavable linkers for combinatorial chemistry.
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    53. Anseth, Kristi S.; Kasko, Andrea M., Photodegradable groups for tunable polymeric materials.
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    54. Anseth, Kristi S.; Kasko, Andrea M.; Tibbitt, Mark W.; Kloxin, April M.; Sridhar, Balaji, Photodegradable groups for tunable polymeric materials.
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    55. Kutateladze, Andrei G.; Kurchan, Alexei; Kottani, Rudresha; Majjigapu, Janaki, Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system.
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    56. Gouliaev, Alex Haahr; Holtmann, Anette; Pedersen, Henrik; Franch, Thomas, Quasirandom structure and function guided synthesis methods.
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    57. Church, George M.; Mitra, Robi D., Replica amplification of nucleic acid arrays.
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    58. Christensen, Soren Flygenring; Truelsen, Jens Hog; Meldal, Morten; Michael, Roice; Johannsen, Ib, Spatially encoded polymer matrix.
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    59. Inoue, Tadashi; Nagayama, Satoshi; Shishido, Yuji, Substituted aryloxymethyl bicyclicmethyl acetamide compounds.
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    60. Smythe, Mark Leslie; Meutermans, Wim Denis Frans; Bourne, Gregory Thomas; McGeary, Ross Peter, Synthesis of cyclic peptides.
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    61. Pedersen, Henrik; Gouilaev, Alex Haahr; Franch, Thomas; Sams, Christian Klarner; Olsen, Eva Kampmann; Sløk, Frank Abilgaard; Husemoen, Gitte Nystrup; Felding, Jakob; Hyldtoft, Lene; Nørregaard-Madsen, Mads; Godskesen, Michael Anders; Glad, Sanne Schrøder; Thisted, Thomas; Freskgård, Per-Ola; Holtmann, Anette, Templated molecules and methods for using such molecules.
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