초록 ▼

Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a pharmacologically active agent in a pharmaceutically acceptable carrier. The compositions in one embod

Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a pharmacologically active agent in a pharmaceutically acceptable carrier. The compositions in one embodiment permit transport of pharmacologically active compounds across mucosal membranes for systemic delivery. The polycationic polymer may be, for example, a polycationic carbohydrate such as a chitosan or a chitosan salt or derivative. The therapeutic agent a preferred embodiment is a vaccine or a nucleic acid, such as a gene or antisense oligonucleotide. The composition may be provided in different forms such as a solution, dispersion, powder or in the form of microspheres.

대표청구항 ▼

[ We claim:] [1.] A pharmaceutical composition comprising:a pharmacologically active agent and a polycationic polymer comprising a plurality of cationic groups, in a pharmaceutically acceptable carrier;wherein (i) the polycationic polymer is not a polyamino acid which chelates calcium or magnesium i

[ We claim:] [1.] A pharmaceutical composition comprising:a pharmacologically active agent and a polycationic polymer comprising a plurality of cationic groups, in a pharmaceutically acceptable carrier;wherein (i) the polycationic polymer is not a polyamino acid which chelates calcium or magnesium ions, (ii) the composition does not consist of microcapsules coated with DEAE-dextran, and (iii) if for administration to gut mucosa, the composition does not consist of the active compound and a solution of DEAE-dextran.