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Continuous low-dose administration of parathyroid hormone or its agonist 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-014/00
  • A61K-051/00
  • G01N-033/534
출원번호 US-0724539 (1996-09-30)
발명자 / 주소
  • Chorev Michael
  • Rosenblatt Michael
출원인 / 주소
  • Beth Israel Deaconess Medical Center
대리인 / 주소
    McGowan
인용정보 피인용 횟수 : 31  인용 특허 : 2

초록

A method of promoting bone formation in a human patient, which includes the step of administering continuously to the patient parathyroid hormone or its agonist for a period of at least one month at a dosage between 10 and 400 units/24 hrs. Also disclosed are novel parathyroid hormone agonists.

대표청구항

[ What is claimed is:] [1.] A method of promoting bone formation in a human patient, said method comprising administering continuously to said patient PTH, PTHrP, or an agonist thereof for a period of at least one month at a dosage between 10 and 400 units/24 hrs.

이 특허에 인용된 특허 (2)

  1. Rosenblatt Michael (Ardmore PA) Caporale Lynn H. (Lansdale PA) Nutt Ruth F. (Green Lane PA) Levy Jay J. (Paoli PA) Chorev Michael (Jerusalem ILX), Parathyroid hormone antagonists with simplified synthetic methodology.
  2. Morita Kaoru (Shizuoka JPX) Katsuragi Shigeo (Shizuoka JPX) Noda Toshiharu (Shizuoka JPX), [Nle8, Nle18, Tyr34 or Phe34]-h-PTH peptide derivatives.

이 특허를 인용한 특허 (31)

  1. Chorev, Michael; Rosenblatt, Michael, Analogs of parathyroid hormone and PTH-related protein as bone anabolic agents.
  2. Ameri, Mahmoud; Cormier, Michel J. N.; Maa, Yuh Fun; Kamberi, Marika; Daddona, Peter, Apparatus and method for transdermal delivery of parathyroid hormone agents.
  3. Ameri, Mahmoud; Cormier, Michel J. N.; Maa, Yuh-Fun; Daddona, Peter E.; Kamberl, Marika, Apparatus for transdermal delivery of parathyroid hormone agents.
  4. Cantor, Thomas L., Assessing risk for kidney stones using parathyroid hormone agonist and antagonist.
  5. Donahue, Seth W., Black bear parathyroid hormone and methods of using black bear parathyroid hormone.
  6. Schense, Jason; Watson, John; Arrighi, Isabelle, Local treatment of bone defects.
  7. Christophersen, Jon P.; Motloch, Chester G.; Morrison, John L.; Albrecht, Weston, Method and apparatus for in-situ characterization of energy storage and energy conversion devices.
  8. Cantor, Thomas L.; Gao, Ping, Methods for differentiating and monitoring parathyroid and bone status related diseases.
  9. Cantor, Thomas L.; Gao, Ping, Methods for differentiating and monitoring parathyroid and bone status related diseases.
  10. Cantor, Thomas L.; Gao, Ping, Methods for differentiating and monitoring parathyroid and bone status related diseases.
  11. Donahue, Seth W., Methods of using black bear parathyroid hormone.
  12. Dietrich,John; Ljunghall,Sverker; Sjogren,Sven, Methods useful in the treatment of bone resorption diseases.
  13. Cantor, Thomas L.; Gao, Ping, Methods, kits, and antibodies for detecting parathyroid hormone.
  14. Cantor, Thomas L.; Gao, Ping, Methods, kits, and antibodies for detecting parathyroid hormone.
  15. Charier, Gaëlle; Müller-Maissen, Manuela; Jen, Anna, PDGF fusion proteins incorporated into fibrin foams.
  16. Lutolf, Matthias; Schense, Jason C.; Hubbell, Jeffrey A.; Jen, Anna, PTH containing cell growth matrix.
  17. Barbier Jean-Rene,CAX ; Morley Paul,CAX ; Neugebauer Witold,CAX ; Ross Virginia J. S.,CAX ; Whitfield James F.,CAX ; Willick Gordon E.,CAX, Parathyroid hormone analogues for the treatment of osteoporosis.
  18. Barbier, Jean-Rene; Morley, Paul; Neugebauer, Witold; Whitfield, James F.; Willick, Gordon E., Parathyroid hormone analogues for the treatment of osteoporosis.
  19. Morley Paul,CAX ; Neugebauer Witold,CAX ; Ross Virginia J. S.,CAX ; Whitfield James F.,CAX ; Willick Gordon E.,CAX ; Barbier Jean-Rene,CAX, Parathyroid hormone analogues for the treatment of osteoporosis.
  20. Cantor, Thomas L., Parathyroid hormone antagonists and uses thereof.
  21. Scadden, David T.; Calvi, Laura M.; Adams, Gregor; Kronenberg, Henry M., Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion.
  22. Scadden,David T.; Calvi,Laura M.; Adams,Gregor; Kronenberg,Henry, Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion.
  23. Scadden, David T.; Calvi, Laura M.; Adams, Gregor; Kronenberg, Henry, Parathyroid hormone receptor activation and stem and progenitor cell expansion.
  24. Scadden, David T.; Calvi, Laura M.; Adams, Gregor; Kronenberg, Henry M., Parathyroid hormone receptor activation and stem and progenitor cell expansion.
  25. Scadden, David T.; Calvi, Laura M.; Adams, Gregor; Kronenberg, Henry M., Parathyroid hormone receptor activation and stem and progenitor cell expansion.
  26. Brown-Augsburger, Patricia Lea; Kohn, Wayne David, Pegylated PTH as PTH receptor modulators and uses thereof.
  27. Kausch, Annemie Rehor; Cerritelli, Simona, Polymeric tissue sealant.
  28. Rehor, Annemie; Cerritelli, Simona, Polymeric tissue sealant.
  29. Schense, Jason; Watson, John; Arrighi, Isabelle, Supplemented matrices for the repair of bone fractures.
  30. Kato, Yukio; Iwamoto, Masahiro; Koike, Tatsuya, Therapeutics of osteoarthritis and inflammatory joint disease.
  31. Stewart,Andrew F., Treatment of bone disorders with skeletal anabolic drugs.

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