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Delivery of nucleotides into organisms by electroporation 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-031/00
출원번호 US-0471642 (1995-06-06)
발명자 / 주소
  • Zewert Thomas E.
  • Pliquett Uwe
  • Langer Robert S.
  • Weaver James C.
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Hamilton, Brook, Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 67  인용 특허 : 0

초록

A method for delivering a nucleotide into an organism includes applying a composition which includes a nucleotide component to epidermis of the organism. The epidermis is electroporated, whereby at least a portion of the composition enters or passes across the epidermis, thereby delivering the nucle

대표청구항

[ We claim:] [1.] A method for delivering a nucleotide component of a composition into an organism, comprising:a) applying the compositions which includes the nucleotide components to stratum corneum of the organism, whereby said nucleotide component directly contacts said stratum corneum; and there

이 특허를 인용한 특허 (67)

  1. Weller, Dwight D.; Geller, Bruce L.; Iversen, Patrick L.; Tilley, Lucas D.; Hassinger, Jed N., Antibacterial antisense oligonucleotide and method.
  2. Geller, Bruce L.; Deere, Jesse D.; Iversen, Patrick L., Antisense antibacterial method and compound.
  3. Geller, Bruce L.; Deere, Jesse D.; Iversen, Patrick L., Antisense antibacterial method and compound.
  4. Geller, Bruce L.; Deere, Jesse D.; Iversen, Patrick L., Antisense antibacterial method and compound.
  5. Geller, Bruce L.; Deere, Jesse D.; Iversen, Patrick L.; Weller, Dwight D., Antisense antibacterial method and compound.
  6. Stein, David A.; Skilling, Douglas E.; Iversen, Patrick L.; Smith, Alvin W.; Weller, Dwight D., Antisense antiviral agent and method for treating ssRNA viral infection.
  7. Iversen, Patrick L.; Stein, David A., Antisense antiviral compound and method for treating ssRNA viral infection.
  8. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  9. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  10. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  11. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  12. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  13. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  14. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  15. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
  16. Eppstein Jonathan A. ; Hatch Michael R., Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications.
  17. Hofmann, Gunter A., Apparatus for electroporation mediated delivery for drugs and genes.
  18. Hofmann,Gunter A., Apparatus for electroporation mediated delivery for drugs and genes.
  19. Hofmann Gunter A., Apparatus for electroporation mediated delivery of drugs and genes.
  20. Lukenbach,Elvin R.; Kaminski,Claudia; Pascal Suisse,Sandrine; Tahar,Maurice, Cleansing compositions.
  21. Lukenbach,Elvin R.; Kaminski,Claudia; Pascal Suisse,Sandrine; Tahar,Maurice, Cleansing compositions comprising a liquid silicone and ester mixture.
  22. Wise, Lyn Marie; Fleming, Stephen Bruce; Mercer, Andrew Allan, Combination treatments and compositions for wound healing comprising viral VEGF.
  23. Goomer,Randal S., Compositions for receptor/liposome mediated transfection and methods of using same.
  24. Walker Jeffrey P. ; Bernard Robert M., Drug delivery system and method.
  25. Nolan, Edward; Rabussay, Dietmar P.; Widera, Georg; Zhang, Lei, Electrical field therapy with reduced histopathological change in muscle.
  26. Nolan, Edward; Rabussay, Dietmar P.; Widera, Georg; Zhang, Lei, Electrical field therapy with reduced histopathological change in muscle.
  27. Bernard Robert M., Electrodes and electrode arrays for generating electroporation inducing electrical fields.
  28. Bernard Robert M., Electrodes and electrode arrays for generating electroporation inducing electrical fields.
  29. Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T.; Niemiec, Susan M., Electrotransort device comprising blades.
  30. Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T., Electrotransport delivery system comprising internal sensors.
  31. Naasani, Imad, Functionalized fluorescent nanocrystal detection system.
  32. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
  33. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
  34. Ferek-Petric, Bozidar, Implantable electroporation therapy device and method for using same.
  35. Weaver, James C.; Anderson, R. Rox; Herndon, Terry O; Gowrishankar, T. R.; Gift, Elizabeth A.; Gonzalez, Salvador, Localized molecular and ionic transport to and from tissues.
  36. Freyman,Toby, Magnetically enhanced injection catheter.
  37. Vankov, Alexander; Chalberg, Thomas W.; Huie, Jr., Philip; Palanker, Daniel V., Method and apparatus for avalanche-mediated transfer of agents into cells.
  38. Zhang Lei ; Hofmann Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
  39. Zhang, Lei; Hofmann, Gunter A., Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications.
  40. De Beenhouwer Hans,BEX ; Portaels Fran.cedilla.oise,BEX ; nckx Lieve Machtel,BEX ; Jannes Geert,BEX ; Rossau Rudi,BEX, Method for detection of the antibiotic resistance spectrum of mycobacterium species.
  41. Iwai, Ichiro; Hirao, Tetsuji, Method for determining the degree of protein oxidation in a skin sample using oxidized protein in stratum corneum as an indicator.
  42. Smith, Alan; Eppstein, Jonathan A.; Messier, Bernadette; Novakovic, Zoran; McRae, Stuart, Method for transdermal delivery of permeant substances.
  43. Smith, Alan; Eppstein, Jonathan A.; Messier, Bernadette; Novakovic, Zoran; McRae, Stuart, Method for transdermal delivery of permeant substances.
  44. Bureau, Michel; Mir, Lluis; Scherman, Daniel, Method for transferring nucleic acid into multicelled eukaryotic organism cells and combination therefor.
  45. Bureau, Michel; Mir, Lluis; Scherman, Daniel, Method for transferring nucleic acid into striated muscles.
  46. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of electroporation mediated delivery of drugs and genes.
  47. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of programming an array of needle electrodes for electroporation therapy of tissue.
  48. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  49. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  50. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  51. Weaver, James C.; Anderson, R. Rox; Herndon, Terry O., Microscission processes and procedures.
  52. Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Minimally invasive apparatus and method to electroporate drugs and genes into tissue.
  53. Fewell,Jason G; MacLaughlin,Fiona; Smith,Louis C; Nicol,Francois; Rolland,Alain, Nucleic acid formulations for gene delivery and methods of use.
  54. Chalberg, Jr., Thomas W.; Blumenkranz, Mark; Palanker, Daniel V.; Vankov, Alexander; Huie, Jr., Philip; Marmor, Michael F.; Calos, Michele P., Ocular gene therapy using avalanche-mediated transfection.
  55. Hanson, Gunnar J.; Rudolph, Alexander Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  56. Hanson, Gunnar J.; Rudolph, Alexander Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  57. Hanson, Gunnar J.; Rudolph, Charles; Cai, Bao Zhong; Zhou, Ming; Weller, Dwight D., Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups.
  58. Lukenbach, Elvin R.; Kaminski, Claudia; Pascal-Suisse, Sandrine; Tahar, Maurice; Ruggiero, Monica, Personal care compositions comprising liquid ester mixtures.
  59. Kraft, Edward R.; Kulp, Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  60. Kraft,Edward R.; Kulp,Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  61. Dev, Nagendu B.; Hofmann, Gunter A.; Nolan, Edward; Rabussay, Dietmar P.; Tonnessen, Arnt; Widera, Georg; Zhang, Lei, Skin and muscle-targeted gene therapy by pulsed electrical field.
  62. Dev, Nagendu B.; Hofmann, Gunter A.; Nolan, Edward; Rabussay, Dietmar P.; Tonnessen, Arnt; Widera, Georg; Zhang, Lei, Skin and muscle-targeted gene therapy by pulsed electrical field.
  63. Birchall, James; Levin, Galit; Gershonowitz, Amikam, Transdermal delivery system for polynucleotides.
  64. Eppstein, Jonathan; McRae, Stuart, Transdermal integrated actuator device, methods of making and using same.
  65. McRae, Stuart; Bowerman, Wendy E.; Braun, Stephen Wilson; Spiehl, Regina; Messier, Bernadette; Farquhar, David; Henkel, Erin Koch; O'Leary, Jeremiah Peter; Fisher, Mark James; Kascak, Uros; Lantz, Loren J.; Novakovic, Zoran; Eppstein, Jonathan, Transdermal porator and patch system and method for using same.
  66. Messier, Bernadette; Novakovic, Zoran; O'Leary, Jeremiah Peter; Spiehl, Regina; Bowerman, Wendy E.; Braun, Stephen Wilson; Eppstein, Jonathan; Farquhar, David; Fisher, Mark James; Kascak, Uros; Henkel, Erin Koch; Lantz, Loren J.; McRae, Stuart, Transdermal porator and patch system and method for using same.
  67. Iversen, Patrick L., dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups.
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