초록

Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an .alpha.-ketoamide to the corresponding .alpha.-hydroxyamide in the presence of an appropriate reducing agent.

대표청구항 ▼

[ What is claimed is:] [1.] A method for performing a stereospecific reduction reaction of an .alpha.-ketoamide to an .alpha.-hydroxyamide, said method comprising:(a) contacting in a reaction mixture the following species:(i) said .alpha.-ketoamide,(ii) a reducing agent, and(iii) monoclonal antibody

[ What is claimed is:] [1.] A method for performing a stereospecific reduction reaction of an .alpha.-ketoamide to an .alpha.-hydroxyamide, said method comprising:(a) contacting in a reaction mixture the following species:(i) said .alpha.-ketoamide,(ii) a reducing agent, and(iii) monoclonal antibody raised against a hapten comprising an analog of said .alpha.-ketoamide in which the .alpha.-carbonyl group of said .alpha.-ketoamide is replaced by a phosphonate moiety, said monoclonal antibody having been screened on the basis of its catalytic activity toward said reduction reaction and(b) recovering said .alpha.-hydroxyamide from said reaction mixture.