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Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/53
  • C07K-007/04
  • C07K-014/705
  • C07K-014/82
출원번호 US-0414417 (1995-03-31)
발명자 / 주소
  • Cheever Martin A.
  • Disis Mary L.
출원인 / 주소
  • University of Washington
대리인 / 주소
    Seed and Berry LLP
인용정보 피인용 횟수 : 80  인용 특허 : 8

초록 ▼

Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immuno

대표청구항 ▼

[ We claim:] [1.] A method of screening for the presence of a malignancy in a warm-blooded animal, wherein a HER-2/neu oncogene is associated with the malignancy, comprising the steps of:(a) obtaining peripheral blood cells from said warm-blooded animal;(b) incubating said cells with HER-2/neu prote

이 특허에 인용된 특허 (8)

  1. Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA), Antibody steric hindrance immunoassay with two antibodies.
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  2. Uzgiris Egidijus E. (Schenectady NY), Electrophoretic method of detecting antigen-antibody reaction.
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  3. Gordon Julian (Arlesheim CHX) Staehelin Theophil (Arlesheim CHX) Towbin Harry (Allschwil CHX), Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays.
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  4. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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  5. Cheever, Martin A.; Peace, David J., Immune reactivity to expressed activated oncogenes for diagnosis of malignancy.
    상세보기
  6. Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA), Reagents and method employing channeling.
    상세보기
  7. Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E., Reverse sandwich immunoassay.
    상세보기
  8. Miles Laughton E. M. (Stanford CA), Universal reagent 2-site immunoradiometric assay using labelled anti (IgG).
    상세보기

이 특허를 인용한 특허 (80)

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