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Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/53
  • C07K-007/04
  • C07K-014/705
  • C07K-014/82
출원번호 US-0414417 (1995-03-31)
발명자 / 주소
  • Cheever Martin A.
  • Disis Mary L.
출원인 / 주소
  • University of Washington
대리인 / 주소
    Seed and Berry LLP
인용정보 피인용 횟수 : 80  인용 특허 : 8

초록

Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immuno

대표청구항

[ We claim:] [1.] A method of screening for the presence of a malignancy in a warm-blooded animal, wherein a HER-2/neu oncogene is associated with the malignancy, comprising the steps of:(a) obtaining peripheral blood cells from said warm-blooded animal;(b) incubating said cells with HER-2/neu prote

이 특허에 인용된 특허 (8)

  1. Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA), Antibody steric hindrance immunoassay with two antibodies.
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  4. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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  8. Miles Laughton E. M. (Stanford CA), Universal reagent 2-site immunoradiometric assay using labelled anti (IgG).

이 특허를 인용한 특허 (80)

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