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Antisense oligonucleotide modulation of multidrug resistance-associated protein 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/85
  • A61K-048/00
  • C12Q-001/68
  • C07H-021/04
출원번호 US-0835770 (1997-04-08)
발명자 / 주소
  • Baracchini Edgardo
  • Bennett C. Frank
  • Dean Nicholas M.
출원인 / 주소
  • Isis Pharmaceuticals, Inc.
대리인 / 주소
    Law Offices of Jane Massey Licata
인용정보 피인용 횟수 : 615  인용 특허 : 4

초록 ▼

Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are s

대표청구항

[ What is claimed is:] [1.] An oligonucleotide comprising 8 to 30 nucleotides specifically hybridizable with a nucleic acid encoding multidrug resistance-associated protein and capable of inhibiting the expression of multidrug resistance-associated protein.

이 특허에 인용된 특허 (4)

  1. Cook P. Dan (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA) Manoharan Muthiah (Carlsbad CA), N-2 substituted purines.
    상세보기
  2. Cook Philip D. (Carlsbad CA) Guinosso Charles J. (Carlsbad CA), Polyamine conjugated oligonucleotides.
    상세보기
  3. Cook Philip D. (Carlsbad CA) Guinosso Charles J. (Carlsbad CA), Polyamine conjugated oligonucleotides.
    상세보기
  4. Summerton, James E.; Weller, Dwight D., Uncharged morpholino-based polymers having achiral intersubunit linkages.
    상세보기

이 특허를 인용한 특허 (615)

  1. Hermeking, Heiko; Vogelstein, Bert; Kinzler, Kenneth W., 14-3-3&sgr; arrests the cell cycle.
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  2. Prakash, Thazha P.; Baker, Brenda F.; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Crooke, Stanley T., 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations.
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  3. Rohloff, John; Janjic, Nebojsa; Carter, Jeffrey D.; Fowler, Catherine, 5-position modified pyrimidines and their use.
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  4. Rohloff, John; Janjic, Nebojsa; Carter, Jeffrey D.; Fowler, Catherine, 5-position modified pyrimidines and their use.
    상세보기
  5. Geary, Richard S.; Yu, Zhengrong; Wedel, Mark K.; Tribble, Diane, Administering antisense oligonucleotides complementary to human apolipoprotein B.
    상세보기
  6. Hope, Michael J.; Semple, Sean C.; Chen, Jianxin; Madden, Thomas D.; Cullis, Pieter R.; Ciufolini, Marco A.; Mui, Barbara Low Shoud, Amino lipids and methods for the delivery of nucleic acids.
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  7. Weller, Dwight D.; Geller, Bruce L.; Iversen, Patrick L.; Tilley, Lucas D.; Hassinger, Jed N., Antibacterial antisense oligonucleotide and method.
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  8. Larsen, Flemming; Wahlers, Ulla, Antibodies to MASP-2.
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  9. Larsen, Flemming; Wahlers, Ulla, Antibodies to MASP-2.
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  10. LaCasse, Eric; McManus, Daniel; Durkin, Jon P., Antisense IAP nucleobase oligomers and uses thereof.
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  11. LaCasse, Eric; McManus, Daniel; Durkin, Jonathan P., Antisense IAP nucleobase oligomers and uses thereof.
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  12. Stein, David A.; Skilling, Douglas E.; Iversen, Patrick L.; Smith, Alvin W.; Weller, Dwight D., Antisense antiviral agent and method for treating ssRNA viral infection.
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  13. Iversen, Patrick L., Antisense antiviral compound and method for treating influenza viral infection.
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  14. Iversen, Patrick L., Antisense antiviral compound and method for treating influenza viral infection.
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  15. Stein, David A.; Ge, Qing; Chen, Jianzhu; Iversen, Patrick L.; Moulton, Hong M., Antisense antiviral compound and method for treating influenza viral infection.
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  16. Stein, David A.; Rijnbrand, Cornelis A.; Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compound and method for treating picornavirus infection.
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  17. Iversen, Patrick L.; Stein, David A., Antisense antiviral compound and method for treating ssRNA viral infection.
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  18. Iversen, Patrick L.; Stein, David A.; Weller, Dwight D., Antisense antiviral compound and method for treating ssRNA viral infection.
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  19. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  20. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  21. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  22. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  23. Iversen, Patrick L.; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  24. Stein, David A.; Iversen, Patrick L.; Bavari, Sina, Antisense antiviral compounds and methods for treating a filovirus infection.
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  25. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  26. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  27. Stein, David A.; Iversen, Patrick L.; Bavari, Sina; Weller, Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  28. Stein,David A.; Iversen,Patrick L.; Bavari,Sina; Weller,Dwight D., Antisense antiviral compounds and methods for treating a filovirus infection.
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  29. Mourich, Dan V.; Marshall, Nikki B.; Iversen, Patrick L., Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis.
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  30. Mourich, Dan V.; Moulton, Hong M.; Hinrichs, David J.; Iversen, Patrick L., Antisense compound for inducing immunological tolerance.
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  31. Swayze, Eric E., Antisense compounds.
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  32. Freier, Susan M.; Rigo, Frank, Antisense compounds targeting genes associated with fibronectin.
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  33. Freier, Susan M.; Rigo, Frank; Dockrell, Mark; Heidibrecht, Felicia, Antisense compounds targeting genes associated with fibronectin.
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  34. Christensen, Signe M.; Mikkelsen, Nikolaj Dam; Frieden, Miriam; Hansen, Henrik Frydenlund; Koch, Troels; Pedersen, Daniel Sejer; Rosenbohm, Christoph; Thrue, Charlotte Albaek; Westergaard, Majken, Antisense design.
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  35. Christensen, Signe M.; Mikkelsen, Nikolaj Dam; Frieden, Miriam; Hansen, Henrik Frydenlund; Koch, Troels; Pedersen, Daniel Sejer; Rosenbohm, Christoph; Thrue, Charlotte Albaek; Westergaard, Majken, Antisense design.
    상세보기
  36. Christensen, Signe M.; Mikkelsen, Nikolaj Dam; Frieden, Miriam; Hansen, Henrik Frydenlund; Koch, Troels; Pedersen, Daniel Sejer; Rosenbohm, Christoph; Thrue, Charlotte Albaek; Westergaard, Majken, Antisense design.
    상세보기
  37. Christensen, Signe M.; Mikkelsen, Nikolaj Dam; Frieden, Miriam; Hansen, Henrik Frydenlund; Koch, Troels; Pedersen, Daniel Sejer; Rosenbohm, Christoph; Thrue, Charlotte Albaek; Westergaard, Majken, Antisense design.
    상세보기
  38. Christensen, Signe M.; Mikkelsen, Nikolaj Dam; Frieden, Miriam; Hansen, Henrik Frydenlund; Koch, Troels; Pedersen, Daniel Sejer; Thrue, Charlotte Albaek; Westergaard, Majken; Rosenbohm, Christoph, Antisense design.
    상세보기
  39. Brent W. Weston ; Kara M. Hiller, Antisense human fucosyltransferase sequences and methods of use thereof.
    상세보기
  40. C. Frank Bennett ; Jacqueline Wyatt, Antisense inhibition of A20 expression.
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  41. Monia Brett P. ; Butler Madeline M. ; Wyatt Jacqueline, Antisense inhibition of C/EBP alpha expression.
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  42. Monia Brett P. ; Butler Madeline M. ; Wyatt Jacqueline, Antisense inhibition of C/EBP beta expression.
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  43. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of EGR-1 expression.
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  44. Baker Brenda F. ; Cowsert Lex M., Antisense inhibition of ETs-2 expression.
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  45. Cowsert Lex M., Antisense inhibition of G-alpha-S1 expression.
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  46. Nicholas M. Dean ; Lex M. Cowsert, Antisense inhibition of HPK/GCK-like kinase expression.
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  47. Bennett, C. Frank; Cowsert, Lex M., Antisense inhibition of Her-2 expression.
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  48. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of Jun N-terminal Kinase Kinase-2 expression.
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  49. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of MAP kinase kinase 6 expression.
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  50. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of PI3K p85 expression.
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  51. Brett P. Monia ; Jacqueline Wyatt, Antisense inhibition of Phosphorylase kinase beta expression.
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  52. Zeng, Hong; Reddy, Gurucharan; Vallerga, Anne; Zarling, David A., Antisense inhibition of RAD51.
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  53. Freier, Susan M., Antisense inhibition of SAP-1 expression.
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  54. Bennett C. Frank ; Cowsert Lex M., Antisense inhibition of SHP-2 expression.
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  55. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of SMAD2 expression.
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  56. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of Smad5 expression.
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  57. Taylor Jennifer K. ; Cowsert Lex M., Antisense inhibition of bcl-6 expression.
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  58. Brett P. Monia ; Susan M. Freier, Antisense inhibition of clusterin expression.
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  59. C. Frank Bennett ; Lex M. Cowsert, Antisense inhibition of cytohesin-1 expression.
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  60. Cowsert, Lex M., Antisense inhibition of dual specific phosphatase 9 expression.
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  61. Popoff Ian ; Brown-Driver Vickie L. ; Cowsert Lex M., Antisense inhibition of e2f transcription factor 1 expression.
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  62. Taylor Jennifer K. ; Cowsert Lex M., Antisense inhibition of fra-1 expression.
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  63. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of human Akt-2 expression.
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  64. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of human Smad1 expression.
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  65. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of human mek1 expression.
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  66. Bennett C. Frank ; Monia Brett P. ; Cowsert Lex M., Antisense inhibition of integrin beta 3 expression.
    상세보기
  67. Monia Brett P. ; Wyatt Jacqueline, Antisense inhibition of methionine aminopeptidase 2 expression.
    상세보기
  68. Baker Brenda F. ; Cowsert Lex M., Antisense inhibition of rank expression.
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  69. Monia Brett P. ; Basilion James P. ; Stanton ; Jr. Vincent P., Antisense inhibition of replication protein a p70 subunit.
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  70. Bennett, C. Frank; Watt, Andrew T., Antisense inhibition of src-c expression.
    상세보기
  71. Monia Brett P. ; Gaarde William A. ; Wancewicz Edward, Antisense inhibition of tert expression.
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  72. Nicholas M. Dean ; Susan F. Murray, Antisense inhibition of transforming growth factor-.beta. expression.
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  73. Flournoy Shin Cheng ; Bennett C. Frank, Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression.
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  74. Bennett, C. Frank; Watt, Andrew T., Antisense inhibition of vascular endothelial growth factor receptor-1 expression.
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  75. Safe, Stephen H.; Chintharlapalli, Sudhakar; Talcott, Susanne U., Antisense microRNA and uses therefor.
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  76. Condon Thomas P. ; Flournoy Shin Cheng, Antisense modulation of ADAM10 expression.
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  77. Zhang, Hong; Watt, Andrew T., Antisense modulation of BCL2-associated X protein expression.
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  78. Zhang, Hong; Wyatt, Jacqueline, Antisense modulation of BH3 interacting domain death agonist expression.
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  79. Lex M. Cowsert ; Susan M. Freier, Antisense modulation of BTAK expression.
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  80. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of C-reactive protein expression.
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  81. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of C-reactive protein expression.
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  82. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of C-reactive protein expression.
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  83. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of C-reactive protein expression.
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  84. Dobie, Kenneth W., Antisense modulation of CD36L 1 expression.
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  85. Bennett, C. Frank; Cowsert, Lex M.; Siwkowski, Andrew M., Antisense modulation of CD40 expression.
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  86. Bennett C. Frank ; Cowsert Lex M., Antisense modulation of CD44 expression.
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  87. Lex M. Cowsert, Antisense modulation of CHK2 expression.
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  88. Bennett, C. Frank; Freier, Susan M., Antisense modulation of CoREST expression.
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  89. Wyatt, Jacqueline, Antisense modulation of EDG1 expression.
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  90. Dean, Nicholas M.; Marcusson, Eric G.; Wyatt, Jacqueline, Antisense modulation of Fas mediated signaling.
    상세보기
  91. Freier, Susan M.; Bhanot, Sanjay, Antisense modulation of GCCR expression.
    상세보기
  92. Freier, Susan M.; Bhanot, Sanjay, Antisense modulation of GCCR expression.
    상세보기
  93. Freier, Susan M.; Bhanot, Sanjay, Antisense modulation of GCGR expression.
    상세보기
  94. Freier, Susan M.; Bhanot, Sanjay, Antisense modulation of GCGR expression.
    상세보기
  95. C. Frank Bennett ; Harris Busch ; Jacqueline Wyatt, Antisense modulation of GU protein expression.
    상세보기
  96. Bennett C. Frank ; Cowsert Lex M., Antisense modulation of Her-3 expression.
    상세보기
  97. Bennett, C. Frank; Freier, Susan M., Antisense modulation of IL-1 receptor-associated kinase-4 expression.
    상세보기
  98. Jacqueline Wyatt, Antisense modulation of MEKK3 expression.
    상세보기
  99. Monia Brett P. ; Gaarde William ; Cowsert Lex M., Antisense modulation of MEKK5 expression.
    상세보기
  100. Weber Michael J. ; Wyatt Jacqueline ; Cowsert Lex M., Antisense modulation of MP-1 expression.
    상세보기
  101. Ward Donna T. ; Cowsert Lex M., Antisense modulation of NCK-2 expression.
    상세보기
  102. Bennett, C. Frank; Monia, Brett P.; Cowsert, Lex M., Antisense modulation of NF-kappa-B p65 subunit expression.
    상세보기
  103. Monia Brett P. ; Cowsert Lex M., Antisense modulation of PI3 kinase p110 beta expression.
    상세보기
  104. Monia Brett P. ; Cowsert Lex M., Antisense modulation of PKA catalytic subunit C-alpha expression.
    상세보기
  105. Watt, Andrew T., Antisense modulation of PLML expression.
    상세보기
  106. Freier, Susan M., Antisense modulation of PPP3R1 expression.
    상세보기
  107. Bhanot, Sanjay; Cowsert, Lex M.; Wyatt, Jacqueline R.; Monia, Brett P.; Butler, Madeline M.; McKay, Robert; Freier, Susan M.; Dobie, Kenneth W., Antisense modulation of PTP1B expression.
    상세보기
  108. Bhanot, Sanjay; Cowsert, Lex M.; Wyatt, Jacqueline R.; Monia, Brett P.; Butler, Madelline M.; McKay, Robert; Freier, Susan M.; Dobie, Kenneth W., Antisense modulation of PTP1B expression.
    상세보기
  109. Bhanot, Sanjay; Freier, Susan M., Antisense modulation of PTP1B expression.
    상세보기
  110. Bhanot, Sanjay; Freier, Susan M., Antisense modulation of PTP1B expression.
    상세보기
  111. Bhanot, Sanjay; Freier, Susan M., Antisense modulation of PTP1B expression.
    상세보기
  112. Cowsert Lex M. ; Wyatt Jacqueline, Antisense modulation of PTP1B expression.
    상세보기
  113. Cowsert, Lex M.; Wyatt, Jacqueline R.; Freier, Susan M.; Monia, Brett P.; Butler, Madeline M.; McKay, Robert, Antisense modulation of PTP1B expression.
    상세보기
  114. Cowsert, Lex M.; Wyatt, Jacqueline; Monia, Brett P.; Butler, Madeline M.; McKay, Robert, Antisense modulation of PTP1B expression.
    상세보기
  115. Cowsert,Lex M.; Wyatt,Jacqueline R., Antisense modulation of PTP1B expression.
    상세보기
  116. Cowsert, Lex M.; Dobie, Kenneth W., Antisense modulation of PTPN12 expression.
    상세보기
  117. Donna T. Ward ; Andrew T. Watt, Antisense modulation of RECQL2 expression.
    상세보기
  118. Jacqueline Wyatt, Antisense modulation of SR-CYP expression.
    상세보기
  119. Bennett C. Frank ; Cowsert Lex M., Antisense modulation of SRC-1 expression.
    상세보기
  120. Cowsert, Lex M., Antisense modulation of Smad6 expression.
    상세보기
  121. Brett P. Monia ; William A. Gaarde ; Susan M. Freier ; Edward Wancewicz, Antisense modulation of TERT expression.
    상세보기
  122. Donna T. Ward ; Andrew T. Watt, Antisense modulation of WRN expression.
    상세보기
  123. Crooke,Rosanne M.; Graham,Mark J.; Tarbet,Kristina Lemonidis, Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression.
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  124. Crooke,Rosanne M.; Tarbet,Kristina Lemonidis; Graham,Mark J., Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression.
    상세보기
  125. Kumar Vijaya B., Antisense modulation of amyloid beta protein expression.
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  126. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of apolipoprotein (a) expression.
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  127. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
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  128. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
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  129. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of apolipoprotein B expression.
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  130. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of apolipoprotein B expression.
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  131. Crooke,Roseanne M.; Graham,Mark; Freier,Susan M., Antisense modulation of apolipoprotein B expression.
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  132. Crooke, Rosanne M.; Graham, Mark J.; Freier, Susan M., Antisense modulation of apolipoprotein B-expression.
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  133. Crooke, Rosanne M.; Graham, Mark J.; Freier, Susan M., Antisense modulation of apolipoprotein B-expression.
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  134. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of c-reactive protein expression.
    상세보기
  135. C. Frank Bennett ; Lex M. Cowsert, Antisense modulation of calreticulin expression.
    상세보기
  136. Robert McKay ; Susan M. Freier ; Jacqueline Wyatt, Antisense modulation of casein kinase 2-alpha prime expression.
    상세보기
  137. Watt, Andrew T., Antisense modulation of caspase 6 expression.
    상세보기
  138. Zhang Hong ; Cowsert Lex M., Antisense modulation of caspase 8 expression.
    상세보기
  139. Andrew T. Watt, Antisense modulation of caspase 9 expression.
    상세보기
  140. Susan M. Freier, Antisense modulation of cellular apoptosis susceptibility gene expression.
    상세보기
  141. Popoff, Ian; Wyatt, Jacqueline, Antisense modulation of damage-specific DNA binding protein 1, p127 expression.
    상세보기
  142. Ian Popoff ; Jacqueline Wyatt, Antisense modulation of damage-specific DNA binding protein 2, p48 expression.
    상세보기
  143. Monia, Brett P.; Watt, Andrew T., Antisense modulation of dual specific phosphatase 5 expression.
    상세보기
  144. Lex M. Cowsert, Antisense modulation of dual specific phosphatase 8 expression.
    상세보기
  145. Dobie, Kenneth W.; Roach, Mark P., Antisense modulation of estrogen receptor alpha expression.
    상세보기
  146. Freier, Susan M., Antisense modulation of fibroblast growth factor receptor 2 expression.
    상세보기
  147. Bhanot, Sanjay; Yu, Xing Xian; McCaleb, Michael L., Antisense modulation of fibroblast growth factor receptor 4 expression.
    상세보기
  148. Bhanot, Sanjay; Yu, Xing-Xian; Freier, Susan M.; Jain, Ravi, Antisense modulation of fibroblast growth factor receptor 4 expression.
    상세보기
  149. Bhanot, Sanjay; Yu, Xing-Xian; Freier, Susan M.; Jain, Ravi, Antisense modulation of fibroblast growth factor receptor 4 expression.
    상세보기
  150. Bennett C. Frank ; Wyatt Jacqueline, Antisense modulation of glioma-associated oncogene-1 expression.
    상세보기
  151. C. Frank Bennett ; Susan M. Freier, Antisense modulation of glioma-associated oncogene-2 expression.
    상세보기
  152. Ward,Donna T.; Watt,Andrew T., Antisense modulation of helicase-moi expression.
    상세보기
  153. Freier, Susan M., Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression.
    상세보기
  154. Brenda F. Baker ; C. Frank Bennett ; Jacqueline Wyatt, Antisense modulation of inhibitor of DNA binding-1 expression.
    상세보기
  155. Brenda F. Baker ; Susan M. Freier, Antisense modulation of interleukin 12 p35 subunit expression.
    상세보기
  156. Dobie, Kenneth W.; Koller, Erich, Antisense modulation of kinesin-like 1 expression.
    상세보기
  157. Dobie, Kenneth W.; Koller, Erich, Antisense modulation of kinesin-like 1 expression.
    상세보기
  158. Dobie, Kenneth W.; Koller, Erich; Jain, Ravi, Antisense modulation of kinesin-like 1 expression.
    상세보기
  159. Dobie,Kenneth W.; Koller,Erich, Antisense modulation of kinesin-like 1 expression.
    상세보기
  160. Dobie,Kenneth W.; Koller,Erich, Antisense modulation of kinesin-like 1 expression.
    상세보기
  161. Murray Susan ; Cowsert Lex M. ; Wyatt Jacqueline, Antisense modulation of macrophage migration inhibitory factor expression.
    상세보기
  162. Crooke, Rosanne M.; Graham, Mark J., Antisense modulation of microsomal triglyceride transfer protein expression.
    상세보기
  163. Dobie, Kenneth W., Antisense modulation of mucin 1, transmembrane expression.
    상세보기
  164. Bennett C. Frank ; Cowsert Lex M., Antisense modulation of nucleolin expression.
    상세보기
  165. Monia, Brett P.; Dobie, Kenneth W.; Freier, Susan M.; Popoff, Ian; Karras, James G., Antisense modulation of p38 mitogen activated protein kinase expression.
    상세보기
  166. C. Frank Bennett ; Susan M. Freier ; Andrew T. Watt, Antisense modulation of phospholipase A2, group VI (Ca2+-independent) expression.
    상세보기
  167. Jacqueline Wyatt, Antisense modulation of phosphorylase kinase alpha 1 expression.
    상세보기
  168. Wyatt, Jacqueline, Antisense modulation of protein phosphatase 2 catalytic subunit beta expression.
    상세보기
  169. Watt, Andrew T., Antisense modulation of raidd expression.
    상세보기
  170. Bennett, C. Frank; Freier, Susan M., Antisense modulation of sphingosine-1-phosphate lyase expression.
    상세보기
  171. Karras James G., Antisense modulation of stat3 expression.
    상세보기
  172. Crooke,Rosanne M.; Graham,Mark J., Antisense modulation of stearoyl-CoA desaturase expression.
    상세보기
  173. Bennett, C. Frank; Dobie, Kenneth W., Antisense modulation of superoxide dismutase 1, soluble expression.
    상세보기
  174. Bennett, C. Frank; Dobie, Kenneth W.; Freier, Susan M.; Condon, Thomas P.; Jain, Ravi; Smith, Richard Alan; Cleveland, Don W., Antisense modulation of superoxide dismutase 1, soluble expression.
    상세보기
  175. Bennett, C. Frank; Freier, Susan M.; Condon, Thomas P., Antisense modulation of superoxide dismutase 1, soluble expression.
    상세보기
  176. Bennett,C. Frank; Dobie,Kenneth, Antisense modulation of superoxide dismutase 1, soluble expression.
    상세보기
  177. Bennett, C. Frank; Swayze, Eric E.; Ackermann, Elizabeth J.; Cowsert, Lex M., Antisense modulation of survivin expression.
    상세보기
  178. Bennett,C. Frank; Ackermann,Elizabeth J.; Cowsert,Lex M., Antisense modulation of survivin expression.
    상세보기
  179. Freier, Susan M.; Wyatt, Jacqueline, Antisense modulation of syntaxin 4 interacting protein expression.
    상세보기
  180. C. Frank Bennett ; Lex M. Cowsert, Antisense modulation of talin expression.
    상세보기
  181. Monia, Brett P.; Freier, Susan M., Antisense modulation of transforming growth factor-beta 3 expression.
    상세보기
  182. C. Frank Bennett ; Andrew T. Watt, Antisense modulation of tumor necrosis factor receptor 2 expression.
    상세보기
  183. Bennett, C. Frank; Watt, Andrew T., Antisense modulation of vascular endothelial growth factor receptor-2 expression.
    상세보기
  184. Wilton, Stephen Donald; Fletcher, Sue; Adams, Abbie; Meloni, Penny, Antisense molecules and methods for treating pathologies.
    상세보기
  185. McKay, Robert; Dean, Nicholas M.; Monia, Brett P.; Nero, Pamela; Gaarde, William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
    상세보기
  186. Honkanen, Richard E.; Dean, Nicholas M., Antisense oligonucleotide inhibition of human serine/threonine protein phosphatase gene expression.
    상세보기
  187. Karras, James G., Antisense oligonucleotide modulation of STAT3 expression.
    상세보기
  188. Karras, James G., Antisense oligonucleotide modulation of STAT3 expression.
    상세보기
  189. Karras, James G., Antisense oligonucleotide modulation of STAT3 expression.
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  190. Karras,James G., Antisense oligonucleotide modulation of STAT3 expression.
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  191. Karras,James G., Antisense oligonucleotide modulation of STAT3 expression.
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  192. Schlingensiepen, Karl Hermann; Brysch, Wolfgang, Antisense oligonucleotide preparation method.
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  193. Schlingensiepen, Karl-Hermann; Brysch, Wolfgang, Antisense oligonucleotide preparation method.
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  194. Peyman, Anuschirwan; Uhlmann, Eugen; Weiser, Caroline, Antisense oligonucleotides against tenascin for treating vitiligo.
    상세보기
  195. Dean, Nicholas M.; Foulkes, J. Gordon; O'Donnell, Niall; Bennett, C. Frank; Freier, Susan M., Antisense oligonucleotides directed against connective tissue growth factor and uses thereof.
    상세보기
  196. Dean, Nicholas M.; Foulkes, J. Gordon; O'Donnell, Niall; Bennett, C. Frank; Frier, Susan M., Antisense oligonucleotides directed against connective tissue growth factor and uses thereof.
    상세보기
  197. Dean, Nicholas M.; Foulkes, J. Gordon; O'Donnell, Niall; Bennett, C. Frank; Frier, Susan M., Antisense oligonucleotides directed against connective tissue growth factor and uses thereof.
    상세보기
  198. LaBarbera,Andrew R.; Wang,YiFang; Zhu,ChangHong, Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use.
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  199. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
    상세보기
  200. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
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  201. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
    상세보기
  202. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
    상세보기
  203. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
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  204. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
    상세보기
  205. Wilton, Stephen Donald; Fletcher, Sue; McClorey, Graham, Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
    상세보기
  206. Liang,Chun; Feng,Dao rong; Yu,Zhi ling, Antisense oligonucleotides targeted to human CDC45.
    상세보기
  207. Raoof, Araz A.; Gudipati, Mangaraju; Bibby, David C.; Weinbach, Susan, Antisense permeation enhancers.
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  208. Gleave,Martin; Miyake,Hideaki, Antisense therapy for hormone-regulated tumors.
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  209. Martin,Gleave; Miyake,Hideaki, Antisense therapy for hormone-regulated tumors.
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  210. C. Frank Bennett ; Lex M. Cowsert, Antisenses inhibition of SRC-2 expression.
    상세보기
  211. Gorenstein,David G.; Yang,Xianbin; Luxon,Bruce A.; Herzog,Norbert, Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries.
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  212. Gleave, Martin; Pollak, Michael N.; Leavitt, Randy J., Bispecific oligonucleotide for the treatment of CNS malignancies.
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  213. Gleave, Martin; Rennie, Paul S.; Miyake, Hideaki; Nelson, Colleen; Zellweger, Tobias, Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides.
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  214. Gleave, Martin; Rennie, Paul S.; Miyake, Hideaki; Nelson, Colleen; Zellweger, Tobias, Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides.
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  215. Gleave, Martin; Rennie, Paul S.; Miyake, Hikeaki; Nelson, Colleen; Zellweger, Tobias, Chemo-and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides.
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  216. Innis, Michael A.; Reinhard, Christoph J.; Zuckermann, Ronald N., Chimeric antisense oligonucleotides and cell transfecting formulations thereof.
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  217. Crooke, Stanley T., Chimeric oligomeric compounds and their use in gene modulation.
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  218. Gleave, Martin E.; Cormack, Scott D., Clusterin antisense therapy for treatment of cancer.
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  219. Gleave, Martin E.; Cormack, Scott D., Clusterin antisense therapy for treatment of cancer.
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  220. Graff, Jeremy Richard, Combination therapy for the treatment of cancer.
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  221. Draper Kenneth G. ; Kisner Daniel L. ; Anderson Kevin P. ; Chapman Sharon, Composition and method for treatment of CMV infections.
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  222. Bennett, Clarence Frank; Ecker, David J.; Cook, Phillip Dan, Composition and methods for the pulmonary delivery of nucleic acids.
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  223. Kmiec,Eric B.; Rice,Michael C.; Liu,Li, Compositions and methods for enhancing oligonucleotide-mediated gene alteration.
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  224. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E., Compositions and methods for modulating HBV expression.
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  225. Rigo, Frank; Freier, Susan M., Compositions and methods for modulating Tau expression.
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  226. Kay, Mark A.; Haussecker, Dirk; Cao, Dan, Compositions and methods for modulating activity of capped small RNAS.
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  227. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E.; Freier, Susan M.; Graham, Mark J.; Crooke, Rosanne M., Compositions and methods for modulating angiopoietin-like 3 expression.
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  228. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E.; Graham, Mark J., Compositions and methods for modulating apolipoprotein (a) expression.
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  229. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E.; Graham, Mark J., Compositions and methods for modulating apolipoprotein C-III expression.
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  230. Prakash, Thazha P.; Seth, Punit P.; Swayze, Eric E.; Bhanot, Sanjay; Freier, Susan M.; Bui, Huynh-Hoa, Compositions and methods for modulating growth hormone receptor expression.
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  231. Freier, Susan M., Compositions and methods for modulation of Mcl-1 expression.
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  232. Baker, Brenda F.; Krainer, Adrian R.; Hua, Yimin, Compositions and methods for modulation of SMN2 splicing.
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  233. Baker, Brenda F.; Krainer, Adrian R.; Hua, Yimin, Compositions and methods for modulation of SMN2 splicing.
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  234. Bennett, C. Frank; Hung, Gene; Rigo, Frank, Compositions and methods for modulation of SMN2 splicing in a subject.
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  235. Bennett, C. Frank; Hung, Gene; Rigo, Frank; Krainer, Adrian R.; Hua, Yimin; Passini, Marco A.; Shihabuddin, Lamya; Cheng, Seng H.; Klinger, Katherine W., Compositions and methods for modulation of SMN2 splicing in a subject.
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  236. Bennett, C. Frank; Hung, Gene; Rigo, Frank; Krainer, Adrian R.; Hua, Yimin; Passini, Marco A.; Shihabuddin, Lamya; Cheng, Seng H.; Klinger, Katherine W., Compositions and methods for modulation of SMN2 splicing in a subject.
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  237. Teng, Ching-Leou; Cook, Phillip Dan; Tillman, Lloyd; Hardee, Gregory E.; Ecker, David J.; Manoharan, Muthiah, Compositions and methods for non-parenteral delivery of oligonucleotides.
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  238. Teng, Ching-Leou; Cook, Phillip Dan; Tillman, Lloyd; Hardee, Gregory E.; Ecker, David J.; Manoharan, Muthiah, Compositions and methods for non-parenteral delivery of oligonucleotides.
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  239. Yu, Xing-Xian; Bhanot, Sanjay, Compositions and methods for the modulation of JNK proteins.
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  240. Crooke,Stanley T.; Ecker,David J.; Sampath,Rangarajan; Freier,Susan M.; Massire,Christian; Hofstadler,Steven A.; Lowery,Kristin Sannes; Swayze,Eric E.; Baker,Brenda F.; Bennett,C. Frank, Compositions and methods for the treatment of severe acute respiratory syndrome (SARS).
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  241. Trieu, Vuong, Compositions and methods for treating pancreatic cancer.
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  242. Trieu, Vuong, Compositions and methods for treating pancreatic cancer.
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  243. Wedel, Mark K.; Miner, Phillip B., Compositions and methods for treatment of pouchitis.
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  244. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  245. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  246. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  247. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  248. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  249. Gleave, Martin E.; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  250. Gleave, Martin; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  251. Gleave, Martin; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  252. Gleave, Martin; Rocchi, Palma; Signaevsky, Maxim; Beraldi, Eliana, Compositions and methods for treatment of prostate and other cancers.
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  253. Gleave,Martin E.; Rocchi,Palma; Signaevsky,Maxim; Beraldi,Eliana, Compositions and methods for treatment of prostate and other cancers.
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  254. Podhajcer,Osvaldo Luis; Ledda,Maria Fernanda; Adris,Soraya Karina; Bravo,Alicia Ines; Mordoh,Jose; Chernajovsky,Yuti, Compositions and methods for tumour therapy.
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  255. Sacks, Frank M.; Tribble, Diane, Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III.
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  256. Barrett, Alan; Beasley, David; Holbrook, Michael, Compositions and methods related to flavivirus envelope protein domain III antigens.
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  257. Dobie, Kenneth W.; Freier, Susan M., Compositions and their uses directed to Gemin Genes.
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  258. Dobie, Kenneth W.; Dean, Nicholas M.; Bennett, C. Frank, Compositions and their uses directed to HBXIP.
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  259. Karras, James G.; Gregory, Susan; Crosby, Jeffrey R.; Guha, Mausumee; Tung, David; Freier, Susan M., Compositions and their uses directed to IL-4R alpha.
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  260. Bhanot, Sanjay; Murray, Susan F., Compositions and their uses directed to PTPR alpha.
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  261. McKay, Robert; Jain, Ravi; Dobie, Kenneth W.; Pandey, Sanjay K.; Bhanot, Sanjay, Compositions and their uses directed to PTPRU.
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  262. McKay, Robert; Jain, Ravi; Dobie, Kenneth W.; Pandey, Sanjay K.; Bhanot, Sanjay, Compositions and their uses directed to PTPRU.
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  263. Bhanot, Sanjay; Monia, Brett P.; Geisler, John G.; McKay, Robert; Dobie, Kenneth W., Compositions and their uses directed to acetyl-CoA carboxylases.
    상세보기
  264. Yu, Xing-Xian; Bhanot, Sanjay; Monia, Brett P., Compositions and their uses directed to diacylglycerol acyltransferase 1.
    상세보기
  265. Yu, Xing-Xian; Bhanot, Sanjay; Monia, Brett P., Compositions and their uses directed to diacylglycerol acyltransferase 1.
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  266. Dobie, Kenneth W.; Freier, Susan M., Compositions and their uses directed to gemin genes.
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  267. Monia, Brett P.; Bennett, C. Frank; Gaarde, William A.; Lockhart, Trisha; McKay, Robert, Compositions and their uses directed to hepcidin.
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  268. Freier, Susan M., Compositions and their uses directed to huntingtin.
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  269. Freier, Susan M., Compositions and their uses directed to huntingtin.
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  270. Freier, Susan M., Compositions and their uses directed to huntingtin.
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  271. Hung, Gene; Leeds, Janet M.; Bennett, C. Frank; Freier, Susan M., Compositions and their uses directed to huntingtin.
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  272. Karras, James G.; Dobie, Kenneth W., Compositions and their uses directed to thymus and activation-regulated chemokine (TARC).
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  273. Allerson, Charles; Bhat, Balkrishen; Eldrup, Anne B.; Manoharan, Muthiah; Griffey, Richard H.; Baker, Brenda F.; Swayze, Eric E., Compositions comprising alternating 2′-modified nucleosides for use in gene modulation.
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  274. Freier, Susan M.; Rigo, Frank, Compositions for modulating C9ORF72 expression.
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  275. Rigo, Frank, Compositions for modulating C9ORF72 expression.
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  276. Freier, Susan M., Compositions for modulating Tau expression.
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  277. Taffy Williams ; George Tuszynski ; Paul Actor, Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions.
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  278. Kaye, Edward M., Compositions for treating muscular dystrophy.
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  279. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression ApoB.
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  280. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of DGAT2.
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  281. Bhanot, Sanjay; Geary, Richard; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCCR.
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  282. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCGR.
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  283. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric; Wancewicz, Edward, Compounds and methods for modulating expression of PCSK9.
    상세보기
  284. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of PTP1B.
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  285. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of SGLT2.
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  286. Bennett, C. Frank; McKay, Robert; Monia, Brett P.; Baker, Brenda F.; Sioufi, Namir, Conjugates for use in hepatocyte free uptake assays.
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  287. Graham, Michael Wayne; Rice, Robert Norman, Control of gene expression.
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  288. Graham, Michael Wayne; Rice, Robert Norman, Control of gene expression.
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  289. Graham, Michael Wayne; Rice, Robert Norman; Waterhouse, Peter Michael, Control of gene expression.
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  290. Rohloff, John; Janjic, Nebojsa; Gawande, Bharat Nathu, Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto.
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  291. Rohloff, John; Janjic, Nebojsa; Gawande, Bharat Nathu, Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto.
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  292. Monia, Brett P.; Freier, Susan M.; Siwkowski, Andrew M.; Guo, Shuling, Diagnosis and treatment of disease.
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  293. Baker, Brenda F.; Kraynack, Bryan A., Double stranded constructs comprising one or more short strands hybridized to a longer strand.
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  294. Rossi, John J.; Castanotto, Daniela; Pfeifer, Gerd; Tommasi, Stella; Morris, Kevin V.; Kim, Daniel H., Double stranded nucleic acid targeting low copy promoter-specific RNA.
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  295. Woolf, Tod, Double-stranded oligonucleotides.
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  296. Woolf, Tod; Wiederholt, Kristin, Double-stranded oligonucleotides.
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  297. Woolf, Tod; Wiederholt, Kristin, Double-stranded oligonucleotides.
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  298. Kmiec, Eric B.; Parekh Olmedo, Hetal; Brachman, Erin E., Enhanced oligonucleotide-mediated nucleic acid sequence alteration.
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  299. Riggins,Gregory J.; Lal,Anita; Loging,William T., Four genetic tumor markers specific for human glioblastoma.
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  300. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
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  301. Hanson, Gunnar J.; Weller, Dwight D.; Cai, Bao Zhong; Zhou, Ming, Functionally-modified oligonucleotides and subunits thereof.
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  302. Swayze, Eric E.; Migawa, Michael T.; Wyrzykiewicz, Tadeusz Krzysztof, Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini.
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  303. Sanghvi, Yogesh S.; Manoharan, Muthiah, Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages.
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  304. Kasid,Usha; Gokhale,Prafulla; Kumar,Deepak; Broustas,Constantinos; Ahmad,Imran; Dritschilo,Anatoly; Rahman,Aquilur, Gene BRCC-2 and diagnostic and therapeutic uses thereof.
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  305. Kasid,Usha; Gokhale,Prafulla; Kumar,Deepak; Boudreau,Howard; Ahmad,Imran; Dritschilo,Anatoly; Rahman,Aquilur, Gene BRCC-3 and diagnostic and therapeutic uses thereof.
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  306. Kasid,Usha; Kumar,Deepak; Ahmad,Imran, Gene SCC-112 and diagnostic and therapeutic uses thereof.
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  307. Kasid,Usha; Sakabe,Isamu; Ahmad,Imran, Gene SHINC-2 and diagnostic and therapeutic uses thereof.
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  308. Kasid,Usha; Sakabe,Isamu; Ahmad,Imran, Gene shinc-3 and diagnostic and therapeutic uses thereof.
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  309. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
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  310. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
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  311. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
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  312. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
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  322. Perera, Ranjan; Koo, Seongjoon; Dean, Nicholas M.; Marcusson, Eric G., Identification of novel pathways, genes and promoter motifs regulating adipogenesis.
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  323. Tachas,George, Inhibition of gastric acid production and/or secretion.
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  324. Jensenius, Jens Chr.; Thiel, Steffen, MASP 2, a complement-fixing enzyme, and uses for it.
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  326. Korneluk, Robert G.; MacKenzie, Alexander E.; Baird, Stephen; Liston, Peter, Mammalian IAP gene family, primers, probes and detection methods.
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  327. Burzio, Luis O.; Villegas, Jaime E.; Burzio, Veronica A., Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein.
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  341. Dawson, Elliott P.; Womble, Kristie E., Method and substances for isolating miRNAs.
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  342. Dawson, Elliott P.; Womble, Kristie E., Method and substances for isolating miRNAs.
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  344. Nahas Nasri,FRX ; Dumas Milne Edwards Jean-Baptiste,FRX, Method for eliminating specific sequences when constructing DNA libraries.
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  348. Bennett, C. Frank; Freier, Susan M.; Griffey, Richard H., Method for inhibiting the activity of mir-155.
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  349. Kreutzer, Roland; Limmer, Stefan, Method for making a 21 nucleotide double stranded RNA chemically linked at one end.
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  350. Mustoe, Thomas A.; Dean, Nicholas M.; Sisco, Mark; Kryger, Zol; Bennett, C. Frank, Method for reducing scarring during wound healing using antisense compounds directed to CTGF.
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  351. LaCasse, Eric; McManus, Daniel; Durkin, Jon P., Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent.
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  352. Stein, David A.; Bestwick, Richard K.; Iversen, Patrick L.; Weller, Dwight D., Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds.
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  353. Gaitanaris, George A.; Bergmann, John E.; Gragerov, Alexander; Hohmann, John; Li, Fusheng; Madisen, Linda; McIlwain, Kellie L.; Pavlova, Maria N.; Vassilatis, Demetri; Zeng, Hongkui, Method of identifying a compound for the treatment or prevention of obesity.
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  354. Esau, Christine; Lollo, Bridget; Bennett, C. Frank; Freier, Susan M.; Griffey, Richard H.; Baker, Brenda F.; Vickers, Timothy A.; Marcusson, Eric G.; Koller, Erich; Swayze, Eric E.; Jain, Ravi; Bhat, Balkrishen; Peralta, Eigen, Method of inhibiting miR-33 using a modified oligonucleotide.
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  355. Nagata,Shigekazu; Yatomi,Takehiro; Suda,Takashi, Method of treating graft versus host disease by administration of a Fas antagonist.
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  356. Dean, Nicholas M.; Krochmal, Lincoln; Hardee, Gregory; Foulkes, J. Gordon; O'Donnell, Niall; Young, Leroy; Jewell, Mark, Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF).
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  357. Monia, Brett P.; McCaleb, Michael L.; Freier, Susan M.; Guo, Shuling, Methods and compositions for modulating alpha-1-antitrypsin expression.
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  358. Crooke, Rosanne M.; Graham, Mark J.; Freier, Susan M.; Lim, Marc; Dibble, Andrew, Methods and compositions for modulating apolipoprotein (a) expression.
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  359. Anil B. Mukherjee ; Gopal C. Kundu IN; Dibyendu K. Panda CA, Methods and compositions for treatment of restenosis.
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  360. Kufe, Donald W., Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3.
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  361. Kufe, Donald W., Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins.
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  362. Waterhouse, Peter Michael; Wang, Ming-Bo, Methods and means for obtaining modified phenotypes.
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  363. Waterhouse, Peter Michael; Wang, Ming-Bo, Methods and means for obtaining modified phenotypes.
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  364. Waterhouse, Peter Michael; Wang, Ming-Bo, Methods and means for obtaining modified phenotypes.
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  365. Waterhouse, Peter Michael; Wang, Ming-Bo; Graham, Michael Wayne, Methods and means for obtaining modified phenotypes.
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  366. Waterhouse, Peter Michael; Wang, Ming-Bo; Graham, Michael Wayne; Smith, Neil A., Methods and means for obtaining modified phenotypes.
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  367. Waterhouse, Peter; Wang, Ming-Bo, Methods and means for obtaining modified phenotypes.
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  368. Dean, Nicholas M.; Foulkes, J. Gordon; O'Donnell, Niall; Bennett, C. Frank; Frier, Susan M., Methods for inhibiting expression of connective tissue growth factor.
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  369. Bennett, C. Frank; Freier, Susan M.; Pulst, Stefan M.; Scoles, Daniel R.; Hung, Gene, Methods for modulating Ataxin 2 expression.
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  370. Bennett, C. Frank; Freier, Susan M.; Rigo, Frank; Cleveland, Don W.; Lagier-Tourenne, Clotilde; Ravits, John M.; Baughn, Michael W., Methods for modulating C9ORF72 expression.
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  371. Monia, Brett P.; Yu, Xing-Xian; Bhanot, Sanjay, Methods for modulating expression of RBP4.
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  372. Bhattacharjee, Gourab; Revenko, Alexey; MacLeod, Robert A., Methods for modulating factor 12 expression.
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  373. Monia, Brett P.; MacLeod, Robert A.; Crosby, Jeffrey R., Methods for modulating factor 12 expression.
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  374. Bhattacharjee, Gourab; Revenko, Alexey; MacLeod, Robert A., Methods for modulating kallikrein (KLKB1) expression.
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  375. Revenko, Alexey; Bhattacharjee, Gourab; MacLeod, Robert A., Methods for modulating kallikrein (KLKB1) expression.
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  376. Bennett, C. Frank; Freier, Susan M.; Condon, Thomas P., Methods for slowing familial ALS disease progression.
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  377. Bennett, C. Frank; Freier, Susan M.; Dobie, Kenneth W., Methods for slowing familial ALS disease progression.
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  378. Demopulos, Gregory A.; Dudler, Thomas; Schwaeble, Hans-Wilhelm, Methods for treating conditions associated with MASP-2 dependent complement activation.
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  379. Demopulos, Gregory A.; Dudler, Thomas; Schwaeble, Hans-Wilhelm, Methods for treating conditions associated with MASP-2 dependent complement activation.
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  380. Demopulos, Gregory A.; Dudler, Thomas; Schwaeble, Hans-Wilhelm, Methods for treating conditions associated with MASP-2 dependent complement activation.
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  381. Demopulos, Gregory A.; Dudler, Thomas; Schwaeble, Hans-Wilhelm, Methods for treating conditions associated with MASP-2 dependent complement activation.
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  382. Schwaeble, Hans-Wilhelm; Tedford, Clark E.; Parent, James B.; Dudler, Thomas; Demopulos, Gregory A., Methods for treating conditions associated with MASP-2 dependent complement activation.
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  383. Schwaeble, Hans-Wilhelm; Dudler, Thomas; Tedford, Clark E.; Parent, James B.; Demopulos, Gregory A., Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation.
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  384. Freier, Susan M.; Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina L.; Bhanot, Sanjay; Tribble, Diane; Watt, Andrew T., Methods for treating hypercholesterolemia.
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  385. Freier, Susan M.; Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina L.; Bhanot, Sanjay; Tribble, Diane; Watt, Andrew T., Methods for treating hypercholesterolemia.
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  386. Freier, Susan M.; Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina M.; Bhanot, Sanjay; Tribble, Diane; Watt, Andrew T., Methods for treating hypercholesterolemia.
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  387. Freier, Susan M.; Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina M.; Bhanot, Sanjay; Watt, Andrew T.; Tribble, Diane, Methods for treating hypercholesterolemia.
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  388. Baulcombe, David Charles; Hamilton, Andrew John, Methods of detecting silencing mammalian cells.
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  389. Gozes, Illana; Brenneman, Douglas E.; Zamostiano, Rachel; Gelber, Edgar; Pinhasov, Albert; Bassan, Merav, Methods of inhibiting cancer cells with ADNF III antisense oligonucleotides.
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  390. Freier, Susan M.; Matveeva, Olga; Tsodikov, Alexander; Giddings, Michael C.; Wyatt, Jacqueline R., Methods of obtaining active antisense compounds.
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  391. Freier, Susan M.; Matveeva, Olga; Tsodikov, Alexander; Giddings, Michael C.; Wyatt, Jacqueline R., Methods of obtaining active antisense compounds.
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  392. Hung, Gene, Methods of treating kennedy's disease.
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  393. Shemi, Amotz, Methods, compositions and systems for local delivery of drugs.
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  394. Wang, Shusheng; Olson, Eric; Zhou, Qinbo, Micro-RNAs involved in macular degeneration.
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  400. Tuschl,Thomas; Lagos Quintana,Marina; Lendeckel,Winfried; Meyer,Jutta; Rauhut,Reinhard, MicroRNA molecules.
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  403. Vickers, Timothy; Dean, Nicholas M., Modification of MYD88 splicing using modified oligonucleotides.
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  404. Vickers, Timothy; Dean, Nicholas M., Modification of MyD88 splicing using modified oligonucleotides.
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  405. Behlke, Mark Aaron; Lennox, Kimberly Ann; Jacobi, Ashley Mae; Owczarzy, Richard; Walder, Joseph Alan, Modifications for antisense compounds.
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  406. Behlke, Mark Aaron; Owczarzy, Richard; You, Yong; Walder, Joseph Alan; Lennox, Kim, Modifications for antisense compounds.
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  407. Behlke, Mark Aaron; Owczarzy, Richard; You, Yong; Walder, Joseph Alan; Lennox, Kim, Modifications for antisense compounds.
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  408. Han, Jang; Seo, Mi-Young; Houghton, Michael, Modified small interfering RNA molecules and methods of use.
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  409. Crooke, Rosanne M.; Graham, Mark J., Modulation of C-reactive protein expression.
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  410. Crooke, Rosanne M.; Graham, Mark J., Modulation of C-reactive protein expression.
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  411. Crooke,Rosanne M.; Graham,Mark J., Modulation of C-reactive protein expression.
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  412. Bennett, C. Frank; Cowsert, Lex M.; Freier, Susan M., Modulation of CD40 expression.
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  413. Bennett, C. Frank; Cowsert, Lex M.; Freier, Susan M., Modulation of CD40 expression.
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  414. Freier, Susan M., Modulation of FR-alpha expression.
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  415. Marcusson, Eric G.; Henry, Scott W.; Kim, Youngsoo; Dobie, Kenneth W., Modulation of HIF-1 beta expression.
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  416. Marcusson, Eric G.; Henry, Scott W.; Kim, Youngsoo; Dobie, Kenneth, Modulation of HIF1-beta expression.
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  417. Ward, Donna T.; Dobie, Kenneth W.; Marcusson, Eric G.; Freier, Susan M., Modulation of HIF1α and HIF2α expression.
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  418. Swayze, Eric E.; Freier, Susan M.; McCaleb, Michael L.; Zhang, Hong, Modulation of Hepatitis B virus (HBV) expression.
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  419. Baker, Brenda F; Bennett, C. Frank; Dobie, Kenneth W.; Myers, Kathleen; Finger, Joshua; Cowsert, Lex M., Modulation of RANKL expression.
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  420. Pandey, Sanjay K.; Bhanot, Sanjay; Marcusson, Eric G.; Freier, Susan M., Modulation of SMRT expression.
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  421. Shanahan, Jr., William R.; Freier, Susan M.; Dobie, Kenneth W., Modulation of STAT 6 expression.
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  422. Freier, Susan M.; Karras, James G., Modulation of STAT5 expression.
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  423. Freier,Susan M.; Karras,James, Modulation of STAT5 expression.
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  424. Guo, Shuling, Modulation of TMPRSS6 expression.
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  425. Rigo, Frank; Ward, Amanda; Meng, Linyan; Beaudet, Arthur L., Modulation of UBE3A-ATS expression.
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  426. Freier, Susan M., Modulation of alpha synuclein expression.
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  427. Macleod, Robert A.; Kim, Youngsoo; Zhou, Tianyuan; Freier, Susan M.; Monia, Brett, Modulation of androgen receptor expression.
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  428. Crooke, Rosanne M.; Graham, Mark J.; Lee, Richard, Modulation of angiopoietin-like 3 expression.
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  429. Crooke, Rosanne M.; Graham, Mark J.; Lee, Richard; Dobie, Kenneth W., Modulation of angiopoietin-like 3 expression.
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  430. Crooke, Rosanne M.; Graham, Mark J., Modulation of apolipoprotein (A) expression.
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  431. Crooke, Rosanne M.; Graham, Mark J., Modulation of apolipoprotein (A) expression.
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  432. Crooke, Rosanne M.; Graham, Mark J., Modulation of apolipoprotein (a) expression.
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  433. Crooke, Rosanne M.; Graham, Mark J., Modulation of apolipoprotein (a) expression.
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  434. Crooke,Rosanne M.; Graham,Mark J., Modulation of apolipoprotein (a) expression.
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  435. Alexander, Veronica J.; Viney, Nicholas J.; Witztum, Joseph L., Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations.
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  436. Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina M., Modulation of apolipoprotein C-III expression.
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  437. Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina M.; Dobie, Kenneth W., Modulation of apolipoprotein C-III expression.
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  438. Crooke, Rosanne M.; Graham, Mark J.; Lemonidis, Kristina M.; Dobie, Kenneth W., Modulation of apolipoprotein C-III expression.
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  439. Mullick, Adam; Crooke, Rosanne M.; Graham, Mark J.; Dobie, Kenneth W.; Lee, Richard, Modulation of apolipoprotein CIII (ApoCIII) expression.
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  440. Crooke, Rosanne M.; Graham, Mark J.; Dobie, Kenneth W., Modulation of apolipoprotein c-III expression.
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  441. Monia, Brett P.; Graham, Mark J., Modulation of diacylglycerol acyltransferase 1 expression.
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  442. Bhanot, Sanjay; Dobie, Kenneth W.; Yu, Xing-Xian; Monia, Brett P., Modulation of diacylglycerol acyltransferase 2 expression.
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  443. Bhanot, Sanjay; Dobie, Kenneth W.; Yu, Xing-Xian; Monia, Brett P., Modulation of diacylglycerol acyltransferase 2 expression.
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  444. Bhanot, Sanjay; Dobie, Kenneth W.; Yu, Xing-Xian; Monia, Brett P., Modulation of diacylglycerol acyltransferase 2 expression.
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  445. Bhanot, Sanjay; Dobie, Kenneth W.; Yu, Xing-Xian; Monia, Brett P., Modulation of diacylglycerol acyltransferase 2 expression.
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  446. Bennett, C. Frank; Freier, Susan M.; MacLeod, Robert A.; Pandey, Sanjay K.; Thornton, Charles A.; Wheeler, Thurman; Cheng, Seng H.; Leger, Andrew; Wentworth, Bruce M., Modulation of dystrophia myotonica-protein kinase (DMPK) expression.
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  447. Dobie, Kenneth W.; Marcusson, Eric G.; Swayze, Eric E.; Bhat, Balkrishen; Graff, Jeremy Richard, Modulation of eIF4E expression.
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  448. Monia, Brett P.; Bhanot, Sanjay; Dobie, Kenneth W.; Jain, Ravi, Modulation of eIF4E-BP1 expression.
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  449. Dobie,Kenneth W., Modulation of endothelial lipase expression.
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  450. Freier, Susan M.; Glass, Christopher K.; Rosenfeld, Michael G.; Li, Wenbo; Lam, Michael T., Modulation of enhancer RNA mediated gene expression.
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  451. Freier, Susan M.; Monia, Brett P.; Zhang, Hong; Zhao, Chenguang; Crosby, Jeffrey R.; Siwkowski, Andrew M., Modulation of factor 11 expression.
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  452. Freier, Susan M.; Monia, Brett P.; Zhang, Hong; Zhao, Chenguang; Crosby, Jeffrey R.; Siwkowski, Andrew M., Modulation of factor 11 expression.
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  453. Freier, Susan M.; Monia, Brett P.; Zhang, Hong; Crosby, Jeffrey R.; Zhao, Chenguang, Modulation of factor 7 expression.
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  454. Dobie, Kenneth W.; Bhanot, Sanjay; McKay, Robert; Pandey, Sanjay K., Modulation of forkhead box O1A expression.
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  455. Dobie, Kenneth W.; Bhanot, Sanjay; McKay, Robert; Pandey, Sanjay K., Modulation of forkhead box O1A expression.
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  456. Dobie, Kenneth W.; Bhanot, Sanjay; Veniant-Ellison, Murielle; Lindberg, Richard A.; Shutter, John R.; McKay, Robert; Pandey, Sanjay K., Modulation of forkhead box O1A expression.
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  457. Dobie,Kenneth W.; Bhanot,Sanjay; Veniant Ellison,Murielle; Lindberg,Richard A.; Shutter,John R., Modulation of forkhead box O1A expression.
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  458. Freier, Susan M., Modulation of glucagon receptor expression.
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  459. Freier, Susan M.; Dobie, Kenneth W.; McKay, Robert; Bhanot, Sanjay, Modulation of glucagon receptor expression.
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  460. Freier,Susan M.; Dobie,Kenneth W.; Bhanot,Sanjay; McKay,Robert, Modulation of glucagon receptor expression.
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  461. Bhanot, Sanjay, Modulation of glucose-6-phosphatase translocase expression.
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  462. Dobie, Kenneth W; Jain, Ravi, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  463. Dobie, Kenneth; Jain, Ravi, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  464. Tachas, George, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  465. Tachas, George, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  466. Tachas, George; Dobie, Kenneth W; Jain, Ravi; Belyea, Christopher I; Heffernan, Mark A, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  467. Tachas, George; Dobie, Kenneth; Jain, Ravi; Belyea, Christopher; Heffernan, Mark, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  468. Tachas, George; Dobie, Kenneth; Jain, Ravi; Belyea, Christopher; Heffernan, Mark, Modulation of growth hormone receptor expression and insulin-like growth factor expression.
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  469. Freier, Susan M., Modulation of hepatitis B virus (HBV) expression.
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  470. Swayze, Eric E.; Freier, Susan M.; McCaleb, Michael L., Modulation of hepatitis B virus (HBV) expression.
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  471. Swayze, Eric E.; Freier, Susan M.; McCaleb, Michael L., Modulation of hepatitis B virus (HBV) expression.
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  472. Hung, Gene; Bennett, C. Frank; Freier, Susan M.; Kordasiewicz, Holly; Stanek, Lisa; Cleveland, Don W.; Cheng, Seng H.; Shihabuddin, Lamya, Modulation of huntingtin expression.
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  475. Dobie, Kenneth W., Modulation of insulin like growth factor I receptor expression.
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  479. Freier, Susan M.; Bui, Huynh-Hoa, Modulation of prekallikrein (PKK) expression.
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