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Method for synthesis of diketopiperazine and diketomorpholine derivatives 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-001/04
  • C07K-005/12
출원번호 US-0731362 (1996-10-11)
발명자 / 주소
  • Szardenings Anna Katrin
  • Campbell David
출원인 / 주소
  • Affymax Technologies N.V., GBX
대리인 / 주소
    Stevens
인용정보 피인용 횟수 : 59  인용 특허 : 5

초록 ▼

The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketo

대표청구항 ▼

[ What is claimed is:] [1.] A method of synthesizing diketomorpholine derivatives, comprising:providing a first amino acid derivative on a solid support;combining an aldehyde or ketone, an isocyanide, and an .alpha.-hydroxy acid with said first amino acid under conditions whereby an .alpha.-hydroxya

이 특허에 인용된 특허 (5)

  1. Coates William J. (Welwyn Garden City PA GB2) Kruse Lawrence I. (Malvern PA), 2-(substituted phenyl)-4-oxo-quinazolines.
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  2. Cody Donna R. (Saline MI) DeWitt Sheila H. H. (Dexter MI) Hodges John C. (Ann Arbor MI) Kiely John S. (Ann Arbor MI) Moos Walter H. (Oakland CA) Pavia Michael R. (Newton MA) Roth Bruce D. (Ann Arbor , Apparatus for multiple simultaneous synthesis.
    상세보기
  3. De Biswanath (Vernon Hills IL) Zydowsky Thomas N. (Waukegan IL) Baker William R. (Libertyville IL) Dellaria Joseph F. (Lindenhurst IL) Rosenberg Saul H. (Libertyville IL) Jae Hwan S. (Glencoe IL), Heterocyclic peptide renin inhibitors.
    상세보기
  4. Talley John J. (Chesterfield MO) Getman Daniel P. (Chesterfield MO) Freskos John N. (Clayton MO) Lin Ko-Chung (St. Louis MO) Heintz Robert M. (Ballwin MO) Rogier ; Jr. Donald J. (St. Louis MO) Berten, Retroviral protease inhibitors.
    상세보기
  5. Ellman Jonathan A. (Berkeley CA), Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support.
    상세보기

이 특허를 인용한 특허 (59)

  1. Bar-Or, David; Thomas, Greg, Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same.
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  2. Borthwick, Alan David; Hickey, Deirdre Mary Bernadette; Liddle, John; Mason, Andrew McMurtrie, Compounds.
    상세보기
  3. Borthwick, Alan David; Hickey, Deirdre Mary Bernadette; Liddle, John; Mason, Andrew McMurtrie, Compounds.
    상세보기
  4. Borthwick, Alan David; Hickey, Deirdre Mary Bernadette; Liddle, John; Mason, Andrew McMurtrie, Compounds.
    상세보기
  5. Bellingham, Richard; Buswell, Andrew Mark; Ironmonger, Victoria; Urquhart, Michael, Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione.
    상세보기
  6. Bellingham, Richard; Buswell, Andrew Mark; Ironmonger, Victoria; Urquhart, Michael, Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione.
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  7. Bar Or, David; Bar Or, Raphael, Diagnosis of multiple sclerosis with diketopiperazines.
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  8. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Dry deposition of materials for microarrays using matrix displacement.
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  9. Bar-Or, David, Implantable medical devices with increased immune tolerance, and methods for making and implanting.
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  10. Campbell David ; Look Gary C. ; Szardenings Anna Katrin ; Patel Dinesh V., Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use.
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  11. Pon Richard T.,CAX ; Yu Shuyuan,CAX, Linker arm for solid support oligonucleotide synthesis and process for production thereof.
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  12. Rao, Nagaraja K. R.; Turner, Stephen, Method of synthesizing diketopiperazines.
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  13. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  14. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  15. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  16. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  17. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  18. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  19. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  20. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
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  21. Liu, Song; Rennells, William Martin, Methods for synthesis of amino-tetrahydroisoquinoline ring compounds.
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  22. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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  23. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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  24. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
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  25. Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
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  26. Ravkin, Ilya; Goldbard, Simon; Hyun, William C.; Zarowitz, Michael A.; Beske, Oren E., Multiplexed cell analysis system.
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  27. Siniaguine,Oleg; Zarowitz,Michael A.; Ravkin,Ilya, Particles with light-polarizing codes.
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  28. Boyce, Jim P.; Howbert, J. Jeffry; Tabone, John C., Pharmaceutical uses and synthesis of diketopiperazines.
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  29. Borthwick, Alan David; Hickey, Deirdre Mary Bernadette; Liddle, John; Mason, Andrew McMurtrie, Piperazinediones as oxytocin receptor antagonists.
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  30. Mjalli Adnan M. M. ; Mason James Christopher ; Arienti Kristen Lee ; Short Kevin Michael ; Kimmich Rachel Denise Anne ; Jones Todd Kevin, Piperazines as inhibitors of fructose-1,6-bisphosphatase (FBPase).
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  31. Pon,Richard T.; Yu,Shuyuan, Reusable solid support for oligonucleotide synthesis.
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  32. Lu,Tianbao; Lafrance, III,Louis V; Parks,Daniel J; Milkiewicz,Karen L; Calvo,Raul R; Cummings,Maxwell D; Kim,Alexander J; Grasberger,Bruce L; Carver, Jr.,Theodore E, Substituted 1,4-benzodiazepines and uses thereof.
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  33. Liddle, John, Substituted diketopiperazines and their use as oxytocin antagonists.
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  34. Liddle, John, Substituted diketopiperazines and their use as oxytocin antagonists.
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  35. Liddle, John, Substituted diketopiperazines and their use as oxytocin antagonists.
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  36. Borthwick, Alan David; Hatley, Richard Jonathan; Hickey, Deirdre Mary Bernadette; Liddle, John; Livermore, David George Hubert; Mason, Andrew McMurtrie; Miller, Neil Derek; Nerozzi, Fabrizio; Sollis, Steven Leslie; Szardenings, Anna Katrin; Wyatt, Paul Graham, Substituted diketopiperazines as oxytocin antagonists.
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  37. Borthwick, Alan David; Hatley, Richard Jonathan; Hickey, Deirdre Mary Bernadette; Liddle, John; Livermore, David George Hubert; Mason, Andrew McMurtrie; Miller, Neil Derek; Nerozzi, Fabrizio; Sollis, Steven Leslie; Szardenings, Anna Katrin; Wyatt, Paul Graham, Substituted diketopiperazines as oxytocin antagonists.
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  38. Borthwick, Alan David; Hatley, Richard Jonathan; Hickey, Deirdre Mary Bernadette; Liddle, John; Livermore, David George Hubert; Mason, Andrew McMurtrie; Miller, Neil Derek; Nerozzi, Fabrizio; Sollis, Steven Leslie; Szardenings, Anna Katrin; Wyatt, Paul Graham, Substituted diketopiperazines as oxytocin antagonists.
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  39. Ravkin, Ilya; Goldbard, Simon; Hyun, William C.; Zarowitz, Michael A., Systems and methods of conducting multiplexed experiments.
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  40. Zarowitz,Michael A.; Edwards,Glenn R., Systems for particle manipulation.
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  41. Bar-Or, David, Therapeutic methods and compounds.
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  44. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
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  45. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
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  46. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
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  50. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
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  51. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
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  52. Bar-Or, David; Bar-Or, Raphael; Shimonkovitz, Richard, Treatment of T-cell mediated diseases.
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  53. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
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  54. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
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  55. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
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  56. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
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  57. Bar-Or, David, Treatment of diseases.
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  58. Bar-Or, David, Treatment of diseases.
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  59. Bar-Or, David, Treatment of joint conditions.
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