초록 ▼

Thermally-inhibited starches and flours are used in pharmaceutical products as a diluent, filler, carrier, binder, disintegrant, coating, thickener, moisture sink, and the like. The starches and flours are inhibited by dehydrating the starch or flour to substantially anhydrous or anhydrous and then

Thermally-inhibited starches and flours are used in pharmaceutical products as a diluent, filler, carrier, binder, disintegrant, coating, thickener, moisture sink, and the like. The starches and flours are inhibited by dehydrating the starch or flour to substantially anhydrous or anhydrous and then heat treating the anhydrous or substantially anhydrous starch or flour for a time and at a temperature sufficient to inhibit the starch or flour. The dehydration can be carried out by heating the starch or flour, by extracting the starch or flour with a solvent, or by freeze drying. Preferably, the pH is adjusted to a neutral pH or above prior to the dehydration and heat treatment.

대표청구항 ▼

[ What is claimed:] [1.] An improved pharmaceutical product containing a pharmaceutically-active ingredient and an effective amount of a thermally-inhibited starch or thermally-inhibited flour which starch or flour is prepared by thermally or non-thermally dehydrating the starch or flour to anhydrou

[ What is claimed:] [1.] An improved pharmaceutical product containing a pharmaceutically-active ingredient and an effective amount of a thermally-inhibited starch or thermally-inhibited flour which starch or flour is prepared by thermally or non-thermally dehydrating the starch or flour to anhydrous or substantially anhydrous and heat-treating the anhydrous or substantially anhydrous starch or flour for a time for up to 20 hours at 120.degree.-180.degree. C., which temperature and time is sufficient to inhibit the starch or flour.