[특허]Perfusive chromatography

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01D-015/08
출원번호	US-0800786 (1997-02-14)
발명자 / 주소	Afeyan Noubar B. Regnier Fred E. Dean Jr. Robert C.
출원인 / 주소	PerSeptive Biosystems, Inc.
대리인 / 주소	Testa, Hurwitz & Thibeault, LLP
인용정보	피인용 횟수 : 39 인용 특허 : 45

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Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices defi

Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.

대표청구항 ▼

[ What is claimed is:] [1.] An adsorption chromatography method for biological solutes comprising the steps of:(A) providing a chromatography matrix defining:interconnected first and second throughpore sets, members of said first throughpore set being interstices between particles packed in a chroma

[ What is claimed is:] [1.] An adsorption chromatography method for biological solutes comprising the steps of:(A) providing a chromatography matrix defining:interconnected first and second throughpore sets, members of said first throughpore set being interstices between particles packed in a chromatography bed, members of said second throughpore set transecting the individual particles, and the geometric relationship between the members of said first throughpore set and of said second throughpore set being effective to induce a convective flow within said second throughpore set, andinteractive regions which interact with a biological solute, said interactive regions in fluid communication with members of said second throughpore set, and(B) passing a solution of a biological solute or an eluant through said matrix at a rate sufficientto induce convective fluid flow through both said throughpore sets andto induce a convective flow rate within members of said second throughpore set greater than the rate of diffusion of said biological solute within said members of said second throughpore set so thatat flow velocities greater than 1000 cm/hr, the rate of biological solute transport in the second throughpore set is dependent on the velocity of liquid passing through the matrix and there exists a range of flow velocities wherein plate height or sorption capacity remain substantially constant.

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