초록 ▼

Systems and methods for separating platelets from blood derive the yield of platelets in real time as processing is accomplished. The systems and method determine an incremental blood volume processed during a succession of incremental time periods during the separation step. The systems and methods

Systems and methods for separating platelets from blood derive the yield of platelets in real time as processing is accomplished. The systems and method determine an incremental blood volume processed during a succession of incremental time periods during the separation step. The systems and methods also estimate a separation efficiency for the separation device during each incremental time period, while also estimating a current count of platelets available from the donor during each incremental time period. The systems and methods multiply the determined incremental blood volume for each incremental time period by the estimated current count of platelets for each incremental time period by the estimated separation efficiency for each incremental time period, to derive an incremental platelet yield for each incremental time period. The systems and methods sum the incremental platelet yields over the succession of incremental time periods to obtain the derived yield of platelets. In this way, the systems and methods take into account the dynamic systemic and physiological changes that occur virtually continuously throughout the blood collection and separation process.

대표청구항 ▼

[ I claim:] [13.] A method for separating platelets from blood comprising the steps ofcontinuously conveying anticoagulated blood containing plasma and platelets from a donor into a separation chamber, whilesubstantially continuously separating the blood into a yield of plasma and a yield of platele

[ I claim:] [13.] A method for separating platelets from blood comprising the steps ofcontinuously conveying anticoagulated blood containing plasma and platelets from a donor into a separation chamber, whilesubstantially continuously separating the blood into a yield of plasma and a yield of platelets,deriving, at least partly while the separation step is occurring, the yield of platelets bydetermining an incremental blood volume processed during a succession of incremental time periods during the separation step,estimating a separation efficiency for the separation device during each incremental time period,estimating a current count of platelets available from the donor during each incremental time period by applying a platelet depletion factor that takes into account both removal of platelets by the separation device and replacement of platelets by the donor through splenic mobilization,multiplying the determined incremental blood volume for each incremental time period by the estimated current count of platelets for each incremental time period by the estimated separation efficiency for each incremental time period, to derive an incremental platelet yield for each incremental time period, andcontinuously summing the incremental platelet yields over the succession of incremental time periods to obtain the derived yield of platelets, andgenerating an output taking into account, at least in part, the derived yield of platelets. [26.] A method according to claim 13 or 14and further including the step of collecting at least a portion of the plasma yield, andwherein the step of generating an output includes deriving a value representing rate at which the portion of plasma is being collected based, at least in part, upon the derived yield of platelets.