초록 ▼

A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl ethers which delivers beneficial agents to a biological environment of use. A statistically significan

A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl ethers which delivers beneficial agents to a biological environment of use. A statistically significant portion of the beneficial agent is covalently bonded within the polymer matrix.

대표청구항 ▼

[ What is claimed is:] [1.] A bioerodible controlled release dosage form comprising:(a) a bioerodible polymer selected from a poly(ortho ester) or polyacetal in which from 1% to 100% of a biologically active ingredient, containing at least 2 hydroxyl groups, is covalently incorporated into a chain b

[ What is claimed is:] [1.] A bioerodible controlled release dosage form comprising:(a) a bioerodible polymer selected from a poly(ortho ester) or polyacetal in which from 1% to 100% of a biologically active ingredient, containing at least 2 hydroxyl groups, is covalently incorporated into a chain backbone of the polymer, wherein(i) during a condensation reaction, the viscosity of the mixture is maintained between 2,000 cp and 2,000,000 cp at 20.degree. C. and 10 sec.sup.-1 prior to extrusion into a mold; and wherein(ii) the total equivalents of hydroxyl are present in stoichiometric ratios of 1 equivalent of hydroxyl to 0.1 to 1.5 equivalents of ketene acetal or vinyl ether, and(b) wherein the biologically active ingredient is(i) present at a level between 0.1 to 50% of the total dosage form weight; and(ii) capable of being released from the polymer into the environment of use.