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특허 상세정보

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Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C07K-007/06    C07K-014/47   
미국특허분류(USC) 530/325 ; 530/328
출원번호 US-0599602 (1996-02-09)
발명자 / 주소
  • Wang Rong-Fu
  • Rosenberg Steven A.
출원인 / 주소
  • The United States of America as represented by the Secretary of the Department of Health and Human Services
대리인 / 주소
    Morgan & Finnegan, L.L.P.
인용정보 피인용 횟수 : 98  인용 특허 : 0
초록

The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by cancer antigen specific T lymphocytes as a tumor rejection antigen. The products of this gene are promising candidates for immunotherapeutic strategies for the treatment and diagnosis of patients with cancer.

대표
청구항

[ We claim:] [1.] A cancer antigen peptide or antigenic epitope thereof encoded by an alternative open reading frame nucleic acid sequence of the TRP-1 gene other than the open reading frame sequence that encodes the normal TRP-1 protein wherein the nucleic acid sequence consists of ORF3 depicted in FIG. 2 as SEQ ID No: 5 or a portion thereof.

이 특허를 인용한 특허 (98)

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