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[미국특허] Pharmaceutical composition for cyclosporines 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/48
출원번호 US-0786314 (1997-01-22)
발명자 / 주소
  • Bhalani Vinayak T.
  • Patel Satishchandra P.
출원인 / 주소
  • Sidmak Laboratories, Inc.
대리인 / 주소
    Greenblum & Bernstein, P.L.C.
인용정보 피인용 횟수 : 105  인용 특허 : 44

초록

The invention comprises a stable solution of cyclosporine forming a polar lipid self-emulsifying drug delivery system ("PLSEDDS"). The composition typically consists of cyclosporine dissolved in a polar lipid, such as a medium chain monoglyceride of C.sub.6 -C.sub.12 fatty acids having a monoglyceri

대표청구항

[ We claim:] [1.] A pharmaceutical composition comprising:a) a cyclosporine or mixture of cyclosporines,b) a surfactant,c) a polar lipid comprising at least 50% medium chain monoglyceride of a fatty acid, ch, on contact with an aqueous phase, forms a fine emulsion.

이 특허에 인용된 특허 (44) 인용/피인용 타임라인 분석

  1. Borkan Lionel (New Vernon NJ) Berry Ira R. (Westfield NJ) Shah Dilip (Flanders NJ), Chewable, edible soft gelatin capsule.
  2. Hewitt Charles W. (Orange CA) Black Kirby S. (Santa Ana CA), Combined topical and systemic method of administration of cyclosporine.
  3. Kelley Vicki E. (Brookline MA) Bennett William M. (Portland OR), Composition having reduced nephrotoxocity comprising a fatty acid containing component and cyclosporine.
  4. Owen Albert J. (West Chester PA) Yiv Seang H. (Wilmington DE) Sarkahian Ani B. (Bryn Mawr PA), Convertible microemulsion formulations.
  5. Handschumacher Robert E. (Guilford CT) Harding Matthew W. (New Haven CT) Speicher David W. (Cheshire CT), Cyclophilin.
  6. Parikh Indu (Chapel Hill NC) Mishra Awadhesh (Durham NC), Cyclosporin emulsions.
  7. Kurihara Kozo (Tokyo JPX) Murano Masaru (Tokyo JPX), Cyclosporin formulations of mono or diglyceride fatty acid.
  8. Cavanak Thomas (Biel-Benken CHX), Cyclosporin galenic forms.
  9. Cavanak Thomas (Salismattenweg 18 CH-4105 Biel-Benken CHX) Posanski Ulrich (In den Kirchenmatten 2 D-7800 Freiburg DEX), Cyclosporin galenic forms.
  10. Woo Jong Soo (Kyunggi-do KRX), Cyclosporin soft capsule composition.
  11. Woo Jong S. (Kyunggi-do KRX), Cyclosporin-containing soft capsule compositions.
  12. Woo Jong S. (Kyunggi-do KRX), Cyclosporin-containing soft capsule compositions.
  13. Lacy Jonathan Ernest (Swindon GBX) Embleton Jonathan Kenneth (Berkshire GBX), Delivery systems for hydrophobic drugs.
  14. Brox Werner (Beerfelden DEX), Ethanol fill formulation for sofgels etc..
  15. Rahman Yueh-Erh (Minneapolis MN) Venkataram Suresh (Minneapolis MN), Freeze-dried liposome mixture containing cyclosporin.
  16. Cavanak Thomas (Oberwil CHX), Galenical compositions.
  17. Handschumacher Robert E. (97 Great Harbor Rd. Guilford CT 06437) Harding Matthew W. (206 Goffe Ter. New Haven CT 06511) Speicher David W. (91 Fawn Dr. Cheshire CT 06410), Immobilized cyclophilin and methods of using such.
  18. Weiner Alan L. (Lawrenceville NJ) Portnoff Joel B. (Richboro PA) Chan Elaine (Feasterville PA), Integrity protected gelatin.
  19. Orbn Erno (Budapest HUX) Balogh Tibor (Budapest HUX) Ila Lajos (Budapest HUX) Ambrus Gbor (Budapest HUX) Jekkel Antnia (Budapest HUX) Elek Sndor (Budapest HUX) Tomori va (Budapest HUX) Elekes Istvn (, Intravenous pharmaceutical composition and process for preparing the same.
  20. Walch Hatto (Laupheim -Baustetten DEX) Fleck Monika (Laupheim DEX) Neuer Klaus (Grossschafhausen DEX), Liquid preparations containing cyclosporin and process for preparing same.
  21. Ebert William R. (Clearwater FL) Hom Foo S. (Clearwater FL) Kindt Warren W. (Clearwater FL), Masticatory soft elastic gelatin capsules and method for the manufacture thereof.
  22. Serno Peter (Cologne DEX), Medicament formulation.
  23. Seth Pawan (Oberwil CHX), Medicament with a delayed release of active ingredient.
  24. Ausman Robert K. (Long Grove IL) Adams Mark (Milwaukee WI) Caballero Gerado (Milwaukee WI) Hamid Rahim (Wauwatosa WI) Hoffman Norman E. (Wales WI) Quebbeman Edward J. (Brookfield WI) Schulte William , Method for drug administration.
  25. Kaswan Renee (Athens GA), Method of increasing tear production by topical administration of cyclosporin.
  26. Nussenblatt Robert B. (Bethesda MD) Palestine Alan G. (Potomac MD), Method of treating ocular diseases by periocular administration of cyclosporine A or G.
  27. Ding Shulin (Irvine CA) Tien Walter L. (Irvine CA) Olejnik Orest (Trabuco Canyon CA), Nonirritating emulsions for sensitive tissue.
  28. Dumont Francis J. (Rahway NJ) Durette Philippe L. (New Providence NJ) Pessolano Arsenio A. (Colonia NJ) Boger Joshua S. (Westfield NJ) Sigal Nolan H. (Westfield NJ), Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin.
  29. Kaswan Renee (Athens GA), Ocular cyclosporine composition.
  30. Kaswan Renee (Athens GA), Ophthalmic treatment by topical administration of cyclosporin.
  31. Desai Ashok J. (Wilmington NC), Oral compositions of proteinaceous medicaments.
  32. Liedtke Rainer K. (Gruenwald DEX), Oral lipid medicinal composition.
  33. Kovacs Istvan (Debrecen HUX) Jusztin Marta (Debrecen HUX) Takacs Erzsebet (Debrecen HUX) Balazs Zoltan (Debrecen HUX) Kiss Ildiko (Ebes HUX) Varga Zsolt (Debrecen HUX) Jancso Sandor (Debrecen HUX) He, Oral pharmaceutical preparation.
  34. Kurihara Kozo (Tokyo JPX) Murano Masaru (Tokyo JPX), Pharmaceutical composition containing cyclosporin in admixture with a 상세보기
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  • Hauer Birgit (Lahr DEX) Meinzer Armin (Freiburg/Munzingen DEX) Posanski Ulrich (Freiburg DEX) Richter Friedrich (Schnbhl-Urtenen CHX), Pharmaceutical compositions comprising cyclosporins.
  • Muller Bernd W. W. (Schlotfeldtsberg 14a 2302 Flintbek DEX) Franzky Hans-Jurgen (von-Coels-Str. 1 5100 Aachen DEX) Klln Claus-Jurgen (Eichofstr. 9 2300 Kiel DEX), Pharmaceutical multicomponent systems and method of preparing same.
  • Schmidt Peter C. (Marburg DEX) Stockebrand Bernd (Monchen-Gladbach DEX) Fischer Gerhard (Eberbach DEX), Pharmaceutical preparation with an active substance of low solubility in water and gastric juices.
  • Popescu Mircea C. (Plainsboro NJ) Tremblay Paul A. (Hamilton NJ) Janoff Andrew S. (Yardley PA) Ostro Marc J. (Princeton NJ) Chan Elaine (Willow Grove PA) Weiner Alan (Lawrenceville NJ), Pharmacological agent-lipid solution preparation.
  • Eckert Theodor (Muenster DEX) Kemper Fritz H. (Muenster DEX) Wischniewski Martin (Neustadt a. Rbge. DEX) Hempel Reinhard (Hanover DEX), Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparati.
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  • Komiya Katsuo (Tokyo JPX) Igarashi Rie (Kawasaki JPX) Takenaga Mitsuko (Kawasaki JPX) Yanagawa Akira (Yokohama JPX) Mizushima Yutaka (Tokyo JPX) Nishimura Tateo (Tokyo JPX) Kudo Toshitaka (Yokohama J, Topical preparations containing cyclosporin.
  • Benet Leslie Z. ; Wacher Vincent J. ; Benet Reed M., Use of essential oils to increase bioavailability of oral pharmaceutical compounds.
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