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Patterning antibodies on a surface 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08J-007/04
  • G01N-033/543
출원번호 US-0816337 (1997-03-13)
발명자 / 주소
  • Brizzolara Robert A.
출원인 / 주소
  • The United States of America as represented by the Secretary of the Navy
대리인 / 주소
    Forrest
인용정보 피인용 횟수 : 43  인용 특허 : 16

초록 ▼

A patterned multiple antibody substrate for use in biosensors or immunosensors is produced by (1) coating an antibody-adsorbent substrate with a material that resists antibody adsorption, (2) using ion beam sputtering, laser ablation, or mechanical scribing to remove the coating at specific sites on

대표청구항 ▼

[ What is claimed is:] [1.] A process for producing a multiple antibody patterned substrate comprising:A. coating an antibody-adsorbent substrate with an antibody-resistant material that is resistant to adsorption of antibodies;B. removing a portion of the antibody-resistant material to produce a ba

이 특허에 인용된 특허 (16)

  1. Caldwell Karin M. E. (Salt Lake County UT) Carlsson Per J. E. (Uppsala UT SEX) Li Jenq-Thun (Salt Lake City UT), Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligand.
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  2. Marinkovich Vincent A. (Palo Alto CA), In vitro method for determining allergic hypersensitivity.
    상세보기
  3. Provancher Donald A. (ChulaVista CA), Laser chem-milling method, apparatus and structure resulting therefrom.
    상세보기
  4. Chang Tse-Wen (Paoli PA), Matrix of antibody-coated spots for determination of antigens.
    상세보기
  5. Giaever Ivar (Schenectady NY), Method and apparatus for detecting immunologic reactions by diffusion in gel.
    상세보기
  6. Giaever ; Ivar, Method for binding antibodies to a surface such that they remain active.
    상세보기
  7. Mizobuchi Yuzo (Asaka JPX) Sato Masamichi (Asaka JPX) Takahashi Tsunehiko (Asaka JPX), Method for producing disk-recording plates.
    상세보기
  8. Loughran James A. (Scotia NY) McMullen James G. (Pattersonville NY) Yerman Alexander J. (Scotia NY), Method for producing via holes in polymer dielectrics.
    상세보기
  9. Giaever Ivar (Schenectady NY), Method for surface immunological detection of biological particles by the use of tagged antibodies.
    상세보기
  10. Markovits Arthur L. (Millburn NJ) Wolfson Stanley W. (West Orange NJ), Method of making microscope slide system.
    상세보기
  11. Garbassi Fabio (Novara ITX) Occhiello Ernesto (Novara ITX) Malatesta Vincenzo (Cologno Monzese ITX), Process of photoetching of superficial coatings based on polymeric materials.
    상세보기
  12. Finlay Carole A. (Woburn MA) Mitchell Marvin (Watertown MA), RIA reagents and processes.
    상세보기
  13. Engelsberg Audrey C. (Milton VT) Fitzpatrick Donna R. (Washington DC), Selective removal of material by irradiation.
    상세보기
  14. Mayne-Banton Veronica I. (Ossining NY) Srinivasan Rangaswamy (Ossining NY), Self developing, photoetching of polyesters by far UV radiation.
    상세보기
  15. Ligler Frances S. (Potomac MD) Bhatia Suresh (Burke VA) Shriver-Lake Lisa C. (Silver Spring MD) Georger Jacque (Springfield VA) Calvert Jeff (Burke VA) Dulcey Charles (Washington DC), Surface modification to create regions resistant to adsorption of biomolecules.
    상세보기
  16. Herron James N. (Salt Lake City UT) Christensen Douglas A. (Salt Lake City UT) Caldwell Karin D. (Salt Lake City UT) Janatov Vera (Prague UT CSX) Huang Shao-Chie (Salt Lake City UT) Wang Hsu-Kun (Sal, Waveguide immunosensor with coating chemistry providing enhanced sensitivity.
    상세보기

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  1. Hanna,Michelle M., Abortive promoter cassettes.
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  2. Hanna, Michelle M.; McCarthy, David, Abscription based molecular detection.
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  3. Apel, William A.; Thompson, Vicki S, Antibody profiling sensitivity through increased reporter antibody layering.
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  4. Apel, William A.; Thompson, Vicki S, Antibody profiling sensitivity through increased reporter antibody layering.
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  5. Apel, William A.; Thompson, Vicki S., Antibody profiling sensitivity through increased reporter antibody layering.
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  6. Apel, William A.; Thompson, Vicki S., Antibody profiling sensitivity through increased reporter antibody layering.
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  7. Kim, Enoch; Kirk, Gregory L.; Schueller, Olivier; Ostuni, Emanuele, Assays for monitoring cell motility in real-time.
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  8. Kirk,Gregory L.; Ostuni,Emanuele; Kim,Enoch; Schueller,Olivier; Sweetnam,Paul, Biological assays using gradients formed in microfluidic systems.
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  9. Williams, Gregory B.; Nothaft, Daniel M.; Enscoe, Glenn F.; Burtner, Kathleen N.; Kangas, Monte E., Combined rapid susceptibility assay and microorganism identification system.
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  10. Williams, John G. K., Composition and method for nucleic acid sequencing.
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  11. Williams, John G. K., Composition and method for nucleic acid sequencing.
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  12. Dias, Peter; Singh, Sujay, Compositions and methods for improved detection and classification of neoplasms.
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  13. Kaplan,Todd, Delta-sigma modulator using LC resonators.
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  14. Kim,Enoch; Cruceta,Johanna R., Device and method for monitoring leukocyte migration.
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  15. Kim, Enoch; Kirk, Gregory L.; Schueller, Olivier; Ostuni, Emanuele, Device for arraying biomolecules and for monitoring cell motility in real-time.
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  16. Kim,Enoch; Kirk,Gregory L.; Schueller,Olivier; Ostuni,Emanuele, Device for monitoring cell motility in real-time.
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  17. Apel, William A.; Thompson, Vicki S.; Lacey, Jeffrey A.; Gentillon, Cynthia A., Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual.
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  18. Thompson, Vicki S.; Lacey, Jeffrey A.; Gentillon, Cynthia A.; Apel, William A., Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual.
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  19. Lassahn, Gordon D.; Lancaster, Gregory D.; Apel, William A.; Thompson, Vicki S., Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture.
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  20. Bailey, Steven R.; Boyle, Christopher T.; Marton, Denes; Banas, Christopher E., In vivo sensor and method of making same.
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  21. Bailey, Steven R.; Boyle, Christopher T.; Marton, Denes; Banas, Christopher E., In vivo sensor and method of making same.
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  22. Kim, Enoch; Kirk, Gregory L.; Schueller, Olivier; Ostuni, Emanuele, Method for arraying biomolecules and for monitoring cell motility in real-time.
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  23. Bhullar,Raghbir S.; Diebold,Eric R.; Hill,Brian S.; Surridge,Nigel A.; Walling,Douglas P., Method of making a biosensor.
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  24. Hanna, Michelle M.; McCarthy, David, Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP).
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  25. Hanna,Michelle M., Methods for determining nucleic acid methylation.
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  26. Hanna, Michelle M.; McCarthy, David, Molecular beacon-based methods for detection of targets using abscription.
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  27. Hanna, Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
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  28. Hanna,Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
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  29. Hanna,Michelle M, Molecular detection systems utilizing reiterative oligonucleotide synthesis.
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  30. Hanna,Michelle M., Molecular detection systems utilizing reiterative oligonucleotide synthesis.
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  31. Kim,Ho Cheol; Miller,Robert Dennis, Patterned substrate with hydrophilic/hydrophobic contrast, and method of use.
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  32. Kim,Ho Cheol; Miller,Robert Dennis, Patterned, high surface area substrate with hydrophilic/hydrophobic contrast, and method of use.
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  33. Brizzolara,Robert A., Patterned, micrometer-sized antibody features.
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  34. Brizzolara Robert A., Patterning antibodies on a surface.
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  35. Mirkin, Chad A.; Lim, Jung-Hyurk; Ginger, David S.; Nam, Jwa-Min; Lee, Ki-Bum; Demers, Linette; Ivanisevic, Albena, Peptide and protein arrays and direct-write lithographic printing of peptides and proteins.
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  36. Pentrenko,Valery A.; Vodyanoy,Vitaly J.; Samoylov,Alexandre M.; Sorokulova,Iryna; Nanduri,Viswaprakash; Chin,Bryan A.; Barbaree,James M.; Neely,W. Charles, Phage ligand sensor devices and uses thereof.
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  37. Sluka Peter,DEX ; Knoll Wolfgang,DEX ; Zizlsperger Manfred,DEX, Process for the application of reagent spots.
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  38. Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E., Rapid classification of biological components.
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  39. Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E., Rapid classification of biological components.
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  40. Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E., Rapid classification of biological components.
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  41. Thompson,Vicki S.; Barrett,Karen B.; Key,Diane E., Rapid classification of biological components.
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  42. Kim,Enoch; Kirk,Gregory L.; Schueller,Olivier; Ostuni,Emanuele, System for monitoring cell motility in real-time.
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  43. Rosann M. Kaylor ; Abraham B. Choi ; Chibueze Obinna Chidebelu-Eze ; Michael Heinrich Herbert Grunze DE, Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors.
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