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Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-016/00
출원번호 US-0633148 (1996-04-16)
발명자 / 주소
  • Morser Michael John
  • Nagashima Mariko
출원인 / 주소
  • Schering Aktiengesellschaft, DEX
대리인 / 주소
    Townsend and Townsend and Crew LLP
인용정보 피인용 횟수 : 58  인용 특허 : 1

초록 ▼

It is a general object of the present invention to provide compositions that specifically interact with advanced glycosylation end products (AGEs) or their receptors. Such compositions may be used in a variety of applications including therapeutic applications, e.g., as blocking agents to inhibit or

대표청구항 ▼

[ What is claimed is:] [1.] An isolated monoclonal antibody, wherein said antibody specifically binds to a soluble human receptor to an advanced glycosylation end-product ("RAGE") polypeptide and wherein the polypeptide consists of an amino acid sequence selected from the group consisting of: WKLNTG

이 특허에 인용된 특허 (1)

  1. Vlassara Helen (New York NY) Cerami Anthony (Shelter Island NY), In vitro assay of mesangial cell-derived receptors for advanced glycosylation endproducts.
    상세보기

이 특허를 인용한 특허 (58)

  1. Tracey, Kevin J.; Wang, Haichao, Antagonists of HMG1 for treating inflammatory conditions.
    상세보기
  2. Tracey, Kevin J.; Yang, Huan; Warren, Jr., Howland Shaw; Fink, Mitchell P., Antibodies to high mobility group-1(HMGB1) B-box polypeptides.
    상세보기
  3. Gu, Jijie; Hsieh, Chung-Ming; Wu, Zhen; DiGiammarino, Enrico L.; Luo, Feng; Fox, Gerard B.; Harlan, John E.; Schmidt, Martin; Loebbert, Ralf; Mueller, Reinhold; Ebert, Ulrich; Nimmrich, Volker, Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof.
    상세보기
  4. Gu, Jijie; Hsieh, Chung-Ming; Wu, Zhen; DiGiammarino, Enrico L.; Luo, Feng; Fox, Gerard B.; Harlan, John E.; Schmidt, Martin; Loebbert, Ralf; Mueller, Reinhold; Ebert, Ulrich; Nimmrich, Volker, Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof.
    상세보기
  5. Mjalli, Adnan M. M.; Andrews, Robert C.; Gopalaswamy, Ramesh; Hari, Anitha; Avor, Kwasi A.; Qabaja, Ghassan; Guo, Xiao-Chuan; Gupta, Suparna; Jones, David R.; Chen, Xin, Azole derivatives and fused bicyclic azole derivatives as therapeutic agents.
    상세보기
  6. Mjalli,Adnan M. M.; Andrews,Robert C.; Gopalaswamy,Ramesh; Hari,Anitha; Avor,Kwasi S.; Qabaja,Ghassan; Guo,Xiao Chuan; Gupta,Suparna; Jones,David R.; Chen,Xin, Azole derivatives and fused bicyclic azole derivatives as therapeutic agents.
    상세보기
  7. Mjalli,Adnan M. M.; Gopalaswamy,Ramesh, Benzimidazole derivatives as therapeutic agents.
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  8. Mjalli,Adnan M. M.; Gopalaswamy,Ramesh, Benzimidazole derivatives as therapeutic agents.
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  9. Mjalli, Adnan M. M.; Andrews, Robert C.; Gopalaswamy, Ramesh; Wysong, Christopher L., Carboxamide derivatives as therapeutic agents.
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  10. Mjalli,Adnan M. M.; Andrews,Robert C.; Gopalaswamy,Ramesh; Wysong,Chris, Carboxamide derivatives as therapeutic agents.
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  11. Combs, Rodney G.; Roe, Susanna; Ruble, Derrick L., Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions.
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  12. Schmidt,Ann Marie; Stern,David, Extracellular novel RAGE binding protein (EN-RAGE) and uses thereof.
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  13. Schmidt,Ann Marie; Stern,David, Extracellular rage binding protein (EN-RAGE) and uses thereof.
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  14. Tracey, Kevin J.; Wang, Haichao, HMG1 antibody for treating inflammatory conditions.
    상세보기
  15. Tracey, Kevin J.; Wang, Haichao, HMG1 antibody for treating inflammatory conditions.
    상세보기
  16. Tracey, Kevin J.; Yang, Huan, Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents.
    상세보기
  17. Stern, David; Yan, Shi Du; Schmidt, Ann Marie; Lamster, Ira, Ligand binding site of rage and uses thereof.
    상세보기
  18. Zlokovic, Berislav V., Low-density lipoprotein receptor related protein-1 (LRP-1)in clearance of alzheimer's amyloid-beta peptide from the central nervous system.
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  19. Olson, Michael L.; Dalebout, William T., Magnetic resistance mechanism in a cable machine.
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  20. Schmidt, Ann Marie; Stern, David, Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage.
    상세보기
  21. Stern,David; Schmidt,Ann Marie, Method for inhibiting accelerated atherosclerosis in a subject suffering from hypercholesterolemia or hypertriglyceridemia.
    상세보기
  22. Stern, David M.; Schmidt, Ann Marie; Marso, Steven; Topol, Eric; Lincoff, A. Michael, Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury.
    상세보기
  23. Stern, David M.; Schmidt, Ann Marie; Marso, Steven; Topol, Eric; Lincoff, A. Michael, Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury.
    상세보기
  24. Mjalli, Adnan M. M.; Gopalaswamy, Ramesh; Avor, Kwasi S.; Wysong, Christopher L.; Patron, Andrew, Method for the synthesis of compounds of formula I and their uses thereof.
    상세보기
  25. Mjalli,Adnan M. M.; Gopalaswamy,Ramesh; Avor,Kwasi A.; Wysong,Christopher L.; Andrew,Patron, Method for the synthesis of compounds of formula I and their uses thereof.
    상세보기
  26. Stern, David M.; Schmidt, Ann Marie, Method for treating symptoms of diabetes.
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  27. Stern, David M.; Schmidt, Ann Marie, Method for treating symptoms of diabetes.
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  28. Stern, David M.; Schmidt, Ann Marie; Yan, Shi Du; Zlokovic, Berislav, Method to increase cerebral blood flow in amyloid angiopathy.
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  29. Stern, David M.; Schmidt, Ann Marie; Yan, Shi Du; Zlokovic, Berislav, Method to increase cerebral blood flow in amyloid angiopathy.
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  30. Stern,David; Schmidt,Ann Marie, Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts.
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  31. Bleck, Gregory T.; Hilbert, David M., Methods of treatment using rage fusion proteins.
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  32. Shahbaz, Manouchehr M., Methods to identify compounds that modulate RAGE.
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  33. Shahbaz,Manouchehr M., Methods to identify compounds that modulate rage.
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  34. Newman, Walter; Qin, Shixin; O'Keefe, Theresa L.; Obar, Robert A., Monoclonal antibodies against HMGB1.
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  35. Newman, Walter; Qin, Shixin; O'Keefe, Theresa L.; Obar, Robert A., Monoclonal antibodies against HMGB1.
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  36. Schmidt, Ann Marie; Stern, David, Nucleic acid encoding bovine extracellular rage binding protein (en-rage).
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  37. Mjalli, Adnan M. M.; Rothlein, Robert; Tian, Ye Edward; Webster, Jeffrey C., Nucleic acid molecules encoding rage fusion proteins.
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  38. Bleck, Gregory T.; Hilbert, David M., Nucleic acids encoding rage fusion proteins.
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  39. Gohimukkula, Devi R.; Jones, David; Qabaja, Ghassan; Zhu, Jeff J.; Cooper, Jeremy T.; Banner, William K.; Sundermann, Kurt; Bondlela, Muralidhar; Rao, Mohan; Wang, Pingzhen; Gowda, Raju B.; Andrews, Robert C.; Gupta, Suparna; Hari, Anitha; Xie, Rongyuan, Phenyl-heteroaryl derivatives and methods of use thereof.
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  40. Gohimukkula, Devi R.; Jones, David; Qabaja, Ghassan; Zhu, Jeff J.; Cooper, Jeremy T.; Banner, William K.; Sundermann, Kurt; Bondlela, Muralidhar; Rao, Mohan; Wang, Pingzhen; Gowda, Raju B.; Andrews, Robert C.; Gupta, Suparna; Hari, Anitha; Xie, Rongyuan, Phenyl-heteroaryl derivatives and methods of use thereof.
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  41. Gohimukkula, Devi R; Jones, David Robert; Qabaja, Ghassan; Zhu, Jeff J; Cooper, Jeremy T; Banner, William K; Sundermann, Kurt; Bondlela, Muralidhar; Rao, Mohan; Wang, Pingzhen; Gupta, Suparna; Hari, Anitha; Gowda, Raju B; Andrews, Robert C, Phenyl-heteroaryl derivatives and methods of use thereof.
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  42. Ashby, Darren, Post workout massage device.
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  43. Schmidt, Ann Marie; Stern, David M., RAGE G82S-related methods and compositions for treating inflammatory disorders.
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  44. Mjalli, Adnan M. M.; Rothlein, Robert; Tian, Ye Edward; Webster, Jeffrey C.; Benjamin, Eric J., RAGE fusion proteins, formulations, and methods of use thereof.
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  45. O'Keefe,Theresa; Luciano,Peter; Qin,Shixin, RAGE protein derivatives.
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  46. Bleck, Gregory T.; Hilbert, David M., Rage fusion proteins.
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  47. Mjalli, Adnan M. M.; Tian, Ye E.; Webster, Jeffrey C.; Rothlein, Robert, Rage fusion proteins.
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  48. Mjalli, Adnan M. M.; Tian, Ye Edward; Webster, Jeffrey C.; Rothlein, Robert, Rage fusion proteins and methods of use.
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  49. Stern,David M.; Herold,Kevan; Yan,Shi Du; Schmidt,Ann Marie; Lamster,Ira, Rage-related methods for treating inflammation.
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  50. Zlokovic, Berislav V.; Deane, Rashid, Soluble low-density lipoprotein receptor related protein binds directly to Alzheimer's amyloid-beta peptide.
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  51. Jones, David; Gowda, Raju Bore; Xie, Rongyuan, Substituted imidazole derivatives and methods of use thereof.
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  52. Jones, David; Gowda, Raju Bore; Xie, Rongyuan, Substituted imidazole derivatives and methods of use thereof.
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  53. Brammer, Chase, System and method for controlling an exercise device.
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  54. Stern, David M.; Schmidt, Ann Marie; Yan, Shi Du, Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof.
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  55. Orlandi, Cesare; Clark, David J.; Dunn, Imogene M.; Valcarce Lopez, Maria Carmen; Kostura, Matthew J., Treatment of mild and moderate Alzheimer's disease.
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  56. Tracey, Kevin J.; Yang, Huan; Warren, Jr., Howland Shaw; Fink, Mitchell P., Use of HMGB fragments as anti-inflammatory agents.
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  57. Tracey, Kevin J.; Yang, Huan; Warren, Jr., Howland Shaw; Fink, Mitchell P., Use of HMGB fragments as anti-inflammatory agents.
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  58. Anderson, Glenn Mark; Jordan, Robert; Picha, Kristen, sRAGE mimetibody, compositions, methods and uses.
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