초록 ▼

The present invention provides asymmetric bidentate silane reagents from modifying the surface of liquid chromatography supports, the supports and methods of making and using the same. When bonded to the surface of a support material, the resulting modified support material provides improved propert

The present invention provides asymmetric bidentate silane reagents from modifying the surface of liquid chromatography supports, the supports and methods of making and using the same. When bonded to the surface of a support material, the resulting modified support material provides improved properties, such as better separations and more stable support materials, especially when used in liquid chromatography. These bidentate silanes have the general structure: R.sub.1 SiMe(NMe.sub.2)--(CH.sub.2).sub.n --SiMeR.sub.2 (NMe.sub.2). R.sub.1 is an alkyl group having from 1 to 30 carbon atoms, and R.sub.2 is an alkyl group having from 8 to 18 carbon atoms. R.sub.1 is a different alkyl group than R.sub.2. Me is a methyl group, and n has a value 2 or 3. In certain embodiments, R.sub.2 includes at least one functional group. When reacted with a silica surface, the resulting modified surface has a structure: PSiO--[R.sub.1 SiMe--(CH.sub.2).sub.n --SiMeR]--OSiP. PSiO is a surface reacted silica.

대표청구항 ▼

[ What is claimed is:] [1.] A support composition having a structure: EQU PSiO--[R.sub.1 SiMe--(CH.sub.2).sub.n SiMeR.sub.2 ]--OSiP rein n-2 or 3, R.sub.1 is an alkyl group having from 1 to 30 carbon atoms, R.sub.2 is an alkyl group having from 8 to 18 carbon atoms, Me is a methyl group and PSiO is

[ What is claimed is:] [1.] A support composition having a structure: EQU PSiO--[R.sub.1 SiMe--(CH.sub.2).sub.n SiMeR.sub.2 ]--OSiP rein n-2 or 3, R.sub.1 is an alkyl group having from 1 to 30 carbon atoms, R.sub.2 is an alkyl group having from 8 to 18 carbon atoms, Me is a methyl group and PSiO is a surface-reacted silica, and wherein R.sub.1 is a different alkyl group than R.sub.2.