초록

SLPs and PBAs are prepared by the following emulsification process:

대표청구항 ▼

[ We claim:] [1.] A suspension stable for at least about 12 months of colloidal solid lipid particles (SLPs) manufactured by an emulsifying process having the following steps:(a) melting at least one solid agent;(b) heating a dispersion medium to approximately the same temperature as said at least o

[ We claim:] [1.] A suspension stable for at least about 12 months of colloidal solid lipid particles (SLPs) manufactured by an emulsifying process having the following steps:(a) melting at least one solid agent;(b) heating a dispersion medium to approximately the same temperature as said at least one molten solid agent formed by step (a);(c) adding at least one highly mobile water-soluble or dispersible stabilizer, which does not form a separate phase in the dispersion medium, to the dispersion medium in an amount effective after emulsification to stabilize newly created surfaces during recrystallization, and optionally adding at least one lipid-soluble or dispersible stabilizer to said at least one molten agent;(d) premixing said at least one molten agent and the dispersion medium, and subsequently homogenizing the mixture by high pressure homogenization, micro-fluidization and/or ultrasonication; and(e) allowing the homogenized dispersion to cool until solid particles are formed by recrystallization of the dispersed agents,wherein the SLPs consist of a single phase, and are lipids having melting points between approximately 30.degree. C. and 120.degree. C. and are constituted of mono-, di- and triglycerides selected from the group consisting of long chain fatty acids, hydrogenated vegetable oils, fatty acids and their esters, fatty alcohols and their esters and ethers, natural or synthetic waxes, wax alcohols and their esters, sterols, hard paraffins, and mixtures thereof.