초록 ▼

The present invention provides a method of using a reflectance-reading device to determine an initiation time point for measuring the chemical reaction of an analyte from a biological liquid sample on a test surface. The initiation time point is determined by using a device to read a reflectance of

The present invention provides a method of using a reflectance-reading device to determine an initiation time point for measuring the chemical reaction of an analyte from a biological liquid sample on a test surface. The initiation time point is determined by using a device to read a reflectance of a test surface at a plurality of time points, and calculating the K/S ratio of the test surface at each time point according to the Kubelka-Munk equation. As the device continues to calculate a K/S ratio for each time point, the device monitors the rate of change of the K/S ratio with respect to time. The device then determines the initiation time point to be when the rate of change of the K/S ratio is maximal. The present invention also provides a method of measuring the concentration of an analyte on a test surface. The concentration is measured by determining an initiation time point according to the method described above and then measuring the concentration of the analyte at a variable end point. The variable end point is essentially determined to be the time at which the rate of change of a concentration parameter is less than a threshold value.

대표청구항 ▼

[ We claim:] [1.] A method of using a reflectance-reading device to determine an initiation time point for measuring a chemical reaction of an analyte from a biological liquid sample on a test surface, comprising the steps of(a) using a device to read a reflectance R of a test surface at a plurality

[ We claim:] [1.] A method of using a reflectance-reading device to determine an initiation time point for measuring a chemical reaction of an analyte from a biological liquid sample on a test surface, comprising the steps of(a) using a device to read a reflectance R of a test surface at a plurality of time points,(b) calculating a K/S ratio of the test surface at each time point according to an equation EQU K/S=(1-R).sup.2 /2R(c) monitoring a rate of change of the K/S ratio with respect to time, and(d) determining an initiation time point for measuring a chemical reaction when the rate of change of the K/S ratio is maximal.