초록 ▼

Vaccine preparations in stable particulate form are disclosed. An immediate-release preparation comprises an immunogen adsorbed to an aluminum adjuvant. A controlled- or delayed-release preparation comprises microspherical particles comprising a continuous matrix of biodegradable polymer containing

Vaccine preparations in stable particulate form are disclosed. An immediate-release preparation comprises an immunogen adsorbed to an aluminum adjuvant. A controlled- or delayed-release preparation comprises microspherical particles comprising a continuous matrix of biodegradable polymer containing discrete, immunogen-containing regions.

대표청구항 ▼

[ We claim:] [1.] A vaccine preparation in stable, dry particulate form, comprising microspherical particles prepared by spray-drying, said particles comprising an immunogen adsorbed to an aluminum salt adjuvant, said vaccine preparation being a free flowing powder. [11.] A vaccine preparation in st

[ We claim:] [1.] A vaccine preparation in stable, dry particulate form, comprising microspherical particles prepared by spray-drying, said particles comprising an immunogen adsorbed to an aluminum salt adjuvant, said vaccine preparation being a free flowing powder. [11.] A vaccine preparation in stable, dry particulate form, comprising microspherical particles prepared by spray-drying said particles comprising a continuous matrix of biodegradable polymer containing one or more discrete, immunogen-containing regions, said vaccine preparation being a free flowing powder. The vaccine preparation of claim 11, wherein said immunogen-containing regions also contain an adjuvant. The vaccine preparation of claim 11, wherein said immunogen-containing regions contain particles comprising an immunogen adsorbed to an aluminium salt adjuvant. The vaccine preparation of claim 11, wherein said biodegradable polymer is selected from the group consisting of polylactic acid, polyglycolic acid, and copolymers thereof. A method for the production of a vaccine preparation of claim 11, which comprises the steps of forming an emulsion of an aqueous suspension comprising immunogen and optionally an adjuvant in a continuous organic phase having biodegradable polymer dissolved therein, and subsequently spray-drying the water-in-oil emulsion to form microspherical particles. The method of claim 15, wherein said emulsion includes an emulsifier. The method of claim 15, wherein the immunogen is adsorbed to an aluminium salt adjuvant. A method for the production of a vaccine preparation of claim 11, which comprises the steps of forming a suspension of a particulate immunogen-containing material and optionally an adjuvant in a continuous organic phase having biodegradable polymer dissolved therein, and subsequently spray-drying the suspension to form microspherical particles. The method of claim 18, wherein the particulate immunogen-containing material comprises an immunogen adsorbed to an aluminium salt adjuvant. [26.] A vaccine preparation in stable, dry particulate form comprising microspherical particles prepared by spray drying an emulsion of an aqueous suspension comprising immunogen in a continuous organic phase having biodegradable polymer dissolved therein or by spray drying a suspension of particulate immunogen-containing material in a continuous organic phase having biogradable polymer dissolved therein, said vaccine preparation being a free flowing powder.