초록 ▼

The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred implant according to the invention is one tha

The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred implant according to the invention is one that becomes gradually disintegrated in situ the animal. The implant provides for extended sustained delivery of the immunogenic agent into surrounding tissue fluids in the presence of circulating maternal antibodies to provide a priming dose of the immunogenic agent to stimulate substantially immediate antibody production for active immunity against a pathogen when passive protection is no longer provided by circulating maternal antibodies.

대표청구항 ▼

[ What is claimed is:] [1.] A method for inducing active immunity in an animal against an antigen in the presence of circulating maternal antibodies against the antigen, the method comprising:administering a biocompatible solid implant having the antigen releasably contained therein during a period

[ What is claimed is:] [1.] A method for inducing active immunity in an animal against an antigen in the presence of circulating maternal antibodies against the antigen, the method comprising:administering a biocompatible solid implant having the antigen releasably contained therein during a period when maternal antibodies are circulating in the animal;the antigen derived from an organism selected from the group consisting of bacteria, virus, fungi, mold, protozoans, nematodes, helminths, and spirochetes; rein the solid implant provides release of the antigen into tissue fluids of the animal in an amount effective to stimulate active immunity.