초록

Particularly, it provides a medical device in which lubricity is generated on at least a portion of its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions, wherein the lubricity-generating portion is formed by thermoforming.

대표청구항 ▼

[ What is claimed is:] [1.] A process for producing a medical device comprising a substrate and lubricity-expressing surface layer disposed on at least a portion said substrate, wherein said lubricity-expressing surface layer becomes lubricant when it is brought in contact with a body fluid or under

[ What is claimed is:] [1.] A process for producing a medical device comprising a substrate and lubricity-expressing surface layer disposed on at least a portion said substrate, wherein said lubricity-expressing surface layer becomes lubricant when it is brought in contact with a body fluid or under physiological aqueous conditions, said process comprising the step of:(a) thermoforming the lubricity-expressing surface layer and the substrate, wherein,(i) said lubricity-expressing surface layer comprises a modified polyethylene oxide containing at least one reacting group selected from the group consisting of amino group, carboxyl group, and thiol group; and(ii) said substrate comprises a polymer modified with at least one member selected from the group consisting of maleic anhydride, glycidyl (meth)acrylate, and derivatives thereof, and wherein said process is effected(b) under conditions whereby said reacting group of the polyethylene oxide of the lubricity-expressing surface layer reacts with said reacting group of the polymer of the substrate during thermoformation.