[특허]Particle aggregation method and apparatus

[미국특허] Particle aggregation method and apparatus 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/557 G01N-001/18
출원번호	US-0925203 (1997-09-08)
우선권정보	GB-0005128 (1992-03-10)
발명자 / 주소	Coakley William Terence,GBX Grundy Martin Alan,GBX Bolek Werner,ATX
출원인 / 주소	University College Cardiff Consultants Limited, GBX
대리인 / 주소	Schwegman, Lundberg, Woessner, and Kluth, P.A.
인용정보	피인용 횟수 : 47 인용 특허 : 5

초록 ▼

A sample of liquid with suspended particles is contained in a tube and subjected to a standing wave ultrasound field transverse to the tube, the standing wave exhibiting a progressive change in pressure amplitude transverse to the tube, so that particles in suspension are displaced transversely of the tube to one or more predetermined regions; exposure of the sample to the standing wave is then terminated and the particles are allowed to settle, and inspected to determine whether they remain aggregated or whether they dissociate. The ultrasound field is produced by a transducer of tubular form encircling the tube. The invention may be used for agglutination of particles or cells via cross-bridging molecules in immuno-agglutination assays.

대표청구항 ▼

[ We claim:] [1.] A method of carrying out an immuno-agglutination assay, the method comprising:providing a sample of liquid in which particles potentially susceptible to agglutination are suspended;containing said sample within a tube in a manner producing an upper and a lower boundary on said liquid sample within the tube, said lower boundary forming a meniscus;placing said tube such that it is encircled by a tubular ultrasound transducer;exciting said tubular ultrasound transducer to generate a standing wave ultrasound field within said tube, said standing wave field extending radially of said tube and exhibiting a progressive change in pressure amplitude radially within said tube so that particles suspended in said liquid sample are displaced radially of said tube to aggregate at least one predetermined annular region;terminating the exposure of said liquid sample to said standing wave and allowing said particles to settle towards said meniscus; andinspecting said particles to determine whether they remain aggregated together or whether they disperse.

이 특허에 인용된 특허 (5) 인용/피인용 타임라인 분석

Stoker Ronald L. (Bountiful UT), Dissociation of ligand-binder complex using ultrasound.
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Owen Charles S. (Swarthmore PA) Silvia John C. (Warminster PA) D\Angelo Louis (Berlin NJ) Liberti Paul A. (Churchville PA), Magnetic-polymer particles.
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Grundy Martin A. (Dyfed GBX), Monitoring particle aggregation by the use of a meniscus.
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Coakley William Terence (Cardiff GBX) Grundy Martin Alan (Pembroke Dock GBX) Bolex Werner (Vienna ATX), Particle aggregation method and apparatus.
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Stuckart Wolfgang (Keinergasse 17/14 A - 1030 Wien ATX), Process for the separation of substances from a liquid and device for effecting such a process.
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이 특허를 인용한 특허 (47) 인용/피인용 타임라인 분석

Kennedy, III, Thomas J.; Lipkens, Bart; Masi, Louis; Kowalski, III, Stanley; Leidel, Chris, Acoustic bioreactor processes.
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Kennedy, III, Thomas J.; Lipkens, Bart; Masi, Louis; Kowalski, Stanley; Leidel, Chris, Acoustic bioreactor processes.
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Lipkens, Bart; Ross-Johnsrud, Benjamin; Zabolotskaya, Evgenia; Ilinskii, Yuril, Acoustic manipulation of particles in standing wave fields.
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Gilmanshin, Rudolf; Lipkens, Bart, Acoustic methods for separation of cells and pathogens.
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Lipkens, Bart; Gilmanshin, Rudolf; Masi, Louis; Ross-Johnsrud, Benjamin; Miller, Erik; Presz, Jr., Walter M.; Kennedy, III, Thomas J., Acoustic perfusion devices.
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Lipkens, Bart; Miller, Erik; Ross-Johnsrud, Benjamin; Presz, Jr., Walter M.; Chitale, Kedar; Kennedy, III, Thomas J., Acoustic perfusion devices.
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Lipkens, Bart; Gilmanshin, Rudolf; Ross-Johnsrud, Ben; Chitale, Kedar, Acoustic separation of cellular supporting materials from cultured cells.
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Ruffa, Anthony A., Acoustically focused optical lens.
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Lipkens, Bart; McCarthy, Brian; Ross-Johnsrud, Ben; Barnes, Jason; Mealey, Dane; Kennedy, III, Thomas J., Acoustophoresis device with dual acoustophoretic chamber.
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Lipkens, Bart; King, Jeff; Sokolowski, David; Masi, Anthony B.; Kennedy, Brian T.; McCarthy, Brian; Ross-Johnsrud, Benjamin; Dionne, Jason; Mealey, Dane; Barnes, Jason, Acoustophoretic clarification of particle-laden non-flowing fluids.
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Lipkens, Bart; Presz, Walter M.; Chitale, Kedar; Kennedy, III, Thomas J.; Ross-Johnsrud, Ben, Acoustophoretic device for angled wave particle deflection.
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Lipkens, Bart; Dionne, Jason, Acoustophoretic device with piezoelectric transducer array.
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Lipkens, Bart; McCarthy, Brian; Barnes, Jason; Mealey, Dane; Ross-Johnsrud, Ben; Presz, Jr., Walter M.; Chitale, Kedar, Acoustophoretic device with uniform fluid flow.
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Lipkens, Bart; Dionne, Jason; Kennedy, III, Thomas J., Acoustophoretic multi-component separation technology platform.
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Lipkens, Bart; Dionne, Jason; Presz, Jr., Walter M.; Kennedy, III, Thomas J., Acoustophoretic separation technology using multi-dimensional standing waves.
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Lipkens, Bart; Dionne, Jason; Presz, Jr., Walter M.; Kennedy, III, Thomas J., Acoustophoretic separation technology using multi-dimensional standing waves.
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Lipkens, Bart; Dionne, Jason; Presz, Jr., Walter M.; Kennedy, III, Thomas J., Acoustophoretic separation technology using multi-dimensional standing waves.
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Lipkens, Bart; Masi, Louis; Kowalski, III, Stanley; Presz, Jr., Walter M.; Dionne, Jason; Dutra, Brian; Mercado, Ari; Kennedy, III, Thomas J.; Martin, Arthur, Bioreactor using acoustic standing waves.
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Lipkens, Bart; Masi, Louis; Kowalski, III, Stanley; Presz, Jr., Walter M.; Dionne, Jason; Dutra, Brian; Mercado, Ari; Kennedy, III, Thomas J.; Martin, Arthur, Bioreactor using acoustic standing waves.
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Lipkens, Bart; Masi, Louis; Kowalski, III, Stanley; Presz, Jr., Walter M.; Dionne, Jason; Dutra, Brian; Mercado, Ari; Kennedy, III, Thomas J.; Martin, Arthur, Bioreactor using acoustic standing waves.
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Lipkens, Bart; Masi, Louis; Kowalski, III, Stanley; Presz, Jr., Walter M.; Dionne, Jason; Dutra, Brian; Mercado, Ari; Kennedy, III, Thomas J.; Martin, Arthur; Rozembersky, John, Bioreactor using acoustic standing waves.
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Rietman, Edward A.; Lipkens, Bart; Dionne, Jason, Combined acoustic micro filtration and phononic crystal membrane particle separation.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping; Warner, Brian David; Trotter, Joseph T., Devices and methods for manipulating components in a fluid sample.
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Yu, Liping, Devices and methods for separating magnetically labeled moieties in a sample.
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Lipkens, Bart; Musiak, Ronald; Mealey, Dane; Shajii, Ali, Electronic configuration and control for acoustic standing wave generation.
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Presz, Jr., Walter M.; Lipkiens, Bart; Dionne, Jason; Kennedy, III, Thomas J., Fluid dynamic sonic separator.
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Simon,William P.; Massa,John; Posca,Robert J., High volume ultrasonic flow cell.
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Dionne, Jason; Lipkens, Bart; Rietman, Edward, High-volume fast separation of multi-phase components in fluid suspensions.
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Lipkens, Bart; Presz, Jr., Walter M.; King, Jeffrey; Barnes, Jason; Mealey, Dane; McCarthy, Brian; Ross-Johnsrud, Ben; Chitale, Kedar, Large scale acoustic separation device.
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Kahma, Kauko, Measurement of binding rate of a binding substance and an analyte.
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Lal,Amit; Lee,Chung Hoon, Method and apparatus for separating particles by size.
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Poniatowski, John Eugene; Poniatowski, Susan Elizabeth; Walkinshaw, John William, Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid.
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Bystryak, Simon; Ossina, Natalya; Sarvazyan, Armen P., Method and device for ultrasound assisted particle agglutination assay.
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Presz, Jr., Walter M.; Chitale, Kedar; Lipkens, Bart, Methods and apparatus for particle aggregation using acoustic standing waves.
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Lipkens, Bart; Kennedy, III, Thomas J.; King, Jeffrey; Barnes, Jason; McCarthy, Brian; Mealey, Dane; Miller, Erik; Presz, Jr., Walter M.; Ross-Johnsrud, Benjamin; Rozembersky, John, Multi-stage acoustophoresis device.
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Rietman, Edward A.; Lipkens, Bart, Phononic crystal desalination system and methods of use.
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Takeuchi,Yukihisa; Yoshida,Yasuko; Hirota,Toshikazu, Reaction cell and operation method thereof.
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McCarthy, Brian; Ross-Johnsrud, Ben; Lipkens, Bart, Reflector for an acoustophoretic device.
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Lipkens, Bart; Dionne, Jason; Mercado, Ari; Dutra, Brian; Presz, Jr., Walter M.; Kennedy, III, Thomas J.; Masi, Louis, Separation of multi-component fluid through ultrasonic acoustophoresis.
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Lipkens, Bart; Dionne, Jason; Mercado, Ari; Dutra, Brian; Presz, Jr., Walter M.; Kennedy, III, Thomas J.; Masi, Louis, Separation of multi-component fluid through ultrasonic acoustophoresis.
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Lipkens, Bart; Dionne, Jason; Ghoshal, Goutam, System for generating high concentration factors for low cell density suspensions.
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Gil U Lee, Ultrasonic force differentiation assay.
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Lee Gil U, Ultrasonic force differentiation assay.
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Lee, Gil U, Ultrasonic force differentiation assay.
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Dionne, Jason; Lipkens, Bart; Rietman, Edward, Ultrasound and acoustophoresis for water purification.
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[미국특허] Particle aggregation method and apparatus 원문보기