초록 ▼

Streptococcus suis is a pathogen causing serious disease in pigs. It may also be infectious to man. The Streptococcus suis adhesin protein is useful in diagnosis and therapy of said bacteria. Also fragmets of the unique N-terminal part of said protein are immunogenic and can be used in diagnosis an

Streptococcus suis is a pathogen causing serious disease in pigs. It may also be infectious to man. The Streptococcus suis adhesin protein is useful in diagnosis and therapy of said bacteria. Also fragmets of the unique N-terminal part of said protein are immunogenic and can be used in diagnosis an as vaccines. The invention therefore relates to said S. suis adhesin protein fragments, antibodies thereto and nucleotide sequences coding for said fragments. The invention further relates to immunoassay and PCR methods for diagnosing S. suis.

대표청구항 ▼

[ We claim:] [1.] A synthesized or isolated fragment of Streptococcus suis adhesin protein, which fragment comprises residues 1 to 11 from the amino acid sequence Ala-Ser-Pro-Ala-Glu-Ile-Ala-Ser-Phe-Ser-Pro-Xaa-Pro (SEQ ID NO: 2), wherein Xaa is alanine or arginine, and which fragment elicits antibo

[ We claim:] [1.] A synthesized or isolated fragment of Streptococcus suis adhesin protein, which fragment comprises residues 1 to 11 from the amino acid sequence Ala-Ser-Pro-Ala-Glu-Ile-Ala-Ser-Phe-Ser-Pro-Xaa-Pro (SEQ ID NO: 2), wherein Xaa is alanine or arginine, and which fragment elicits antibodies that specifically bind to a Streptococcus suis adhesin protein having a molecular weight of about 18,000 and said protein binds to the Gal.alpha.1-4Gal disaccharide structure.