초록

The invention relates to stable, pharmaceutically usable chewing gum formulations which contain acetylsalicylic acid (ASA) as the active compound, and to a process for their preparation.

대표청구항 ▼

[ We claim:] [1.] An acetylsalicyclic acid-salt releasing chewing gum comprising acetylsalicylic acid, and a basic substance capable of reacting with said acetylsalicylic acid to form an acetylsalicylic acid salt, said gum containing not more than about 2% of water and said acetylsalicylic acid and

[ We claim:] [1.] An acetylsalicyclic acid-salt releasing chewing gum comprising acetylsalicylic acid, and a basic substance capable of reacting with said acetylsalicylic acid to form an acetylsalicylic acid salt, said gum containing not more than about 2% of water and said acetylsalicylic acid and said basic substance being bound in said chewing gum apart from each other sufficiently to prevent them from reacting with each other until said chewing gum is chewed, which gum when chewed in the presence of saliva brings said acetylsalicylic acid into contact with said basic substance so that they react to form said acetylsalicylic acid salt which is then rapidly released to the saliva, said basic substance being selected from the group consisting of an alkaline earth metal carbonate, calcium hydroxide, magnesium hydroxide, light magnesium carbonate, heavy magnesium carbonate or magnesium oxide, tris-(hydroxymethyl)-aminomethane, alkali metal phosphates or alkaline earth metal phosphates and basic amino acids, the amount of basic substance being such that together with the amount of acetylsalicylic acid emploved there results a buffer capacity of between 5 and 15 mEg.