초록 ▼

A bonded phase material useful with a chromatographic separation process. The bonded phase material includes a hydroxyl bearing porous material, a first controlled stoichiometric amount of a first interactive silane covalently bonded to the surface of the hydroxyl bearing porous material and at leas

A bonded phase material useful with a chromatographic separation process. The bonded phase material includes a hydroxyl bearing porous material, a first controlled stoichiometric amount of a first interactive silane covalently bonded to the surface of the hydroxyl bearing porous material and at least one additional interactive silane covalently bonded to the surface of the hydroxyl bearing porous material to provide the porous material with a gradient of functionality of varied polarity creates a unique overall polarity which is not obtainable by the separate interactive silanes themselves. The method of silating the porous material includes sequential application of controlled stoichiometric amounts of the interactive silanes.

대표청구항 ▼

[ What is claimed is:] [1.] A bonded phase material comprising:a hydroxyl bearing porous material, the hydroxyl bearing porous material having a surface;a first controlled stoichiometric amount of a first interactive silane having a first organic functionality covalently bonded to the surface of the

[ What is claimed is:] [1.] A bonded phase material comprising:a hydroxyl bearing porous material, the hydroxyl bearing porous material having a surface;a first controlled stoichiometric amount of a first interactive silane having a first organic functionality covalently bonded to the surface of the hydroxyl bearing porous material; andat least one additional controlled stoichiometric amount of at least one additional interactive silane having an other organic functionality, the other organic functionality being distinct from the first organic functionality, and the at least one additional interactive silane being covalently bonded to the surface of the hydroxyl bearing porous material;wherein the first interactive silane and the at least one additional interactive silane are each present in an amount large enough to provide a coverage of at least about 0.10 molecules per square nanometer of the porous material and thereby provide the porous material with a gradient of functionality of varied polarity which creates a unique overall polarity which is not obtainable by the separate interactive silanes themselves.