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In vitro peptide and antibody display libraries 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12Q-001/70
  • G01N-033/53
출원번호 US-0902623 (1997-07-29)
발명자 / 주소
  • Mattheakis Larry C.
  • Dower William J.
출원인 / 주소
  • Affymax Technologies N.V., GBX
대리인 / 주소
    Stevens
인용정보 피인용 횟수 : 103  인용 특허 : 6

초록

Improved methods and novel compositions for identifying peptides and single-chain antibodies that bind to predetermined receptors or epitopes. Such peptides and antibodies are identified by improved and novel methods for affinity screening of polysomes displaying nascent peptides.

대표청구항 ▼

[ We claim:] [1.] A method for identifying multiple binding specificities of single chain antibodies, said method comprising:contacting under suitable binding conditions a multiplicity of antigen species with a polysome library displaying nascent peptides having a single chain antibody segment; ands

이 특허에 인용된 특허 (6)

  1. Ladner Robert C. (Ijamsville MD) Guterman Sonia K. (Belmont MA) Roberts Bruce L. (Milford MA) Markland William (Milford MA) Ley Arthur C. (Newton MA) Kent Rachel B. (Boxborough MA), Directed evolution of novel binding proteins.
    상세보기
  2. Houghten Richard A. (Solana Beach CA), Means for sequential solid phase organic synthesis and methods using the same.
    상세보기
  3. Lam Kit S. (Tucson AZ) Salmon Sydney E. (Tucson AZ), Method of screening a peptide library.
    상세보기
  4. Schatz Peter J. (Los Altos CA) Cull Millard G. (Oakland CA) Miller Jeff F. (Los Angeles CA), Peptide library and screening method.
    상세보기
  5. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
    상세보기
  6. Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
    상세보기

이 특허를 인용한 특허 (103)

  1. Zhao, Robert Yongxin, Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule.
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  2. Hallahan, Dennis E.; Yan, Heping, Antibodies to GRP78.
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  3. Hallahan, Dennis E.; Yan, Heping, Antibodies to TIP-1.
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  4. Vasquez, Maximiliano; Sivasubramanian, Arvind; Feldhaus, Michael, Antibody libraries.
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  5. Vasquez, Maximiliano; Sivasubramanian, Arvind; Feldhaus, Michael, Antibody libraries.
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  6. Kohno, Tadahiko, Apo-AI/AII peptide derivatives.
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  7. Grant, Steven; Liu, Haiqun; Moulder, Kevin, CD40L-specific monovalent polypeptides.
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  8. Smith, Craig A.; Wiley, Steven; Kaykas, Ajamete; Probst, Peter, CD47 related compositions and methods for treating immunological diseases and disorders.
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  9. Harvey,Barrett R.; Georgiou,George; Iverson,Brent L., Combinatorial protein library screening by periplasmic expression.
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  10. Achilefu, Samuel; Black, Kvar, Compositions and methods for treatment and imaging using nanoparticles.
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